Physical activity and sleep in patients with hypermobile Ehlers–Danlos syndrome and patients with generalized hypermobility spectrum disorder

Abstract

Aims: Research objectively evaluating physical activity (PA) and sleep in adults with hypermobile Ehlers-Danlos syndrome (hEDS) and generalized hypermobility spectrum disorder (G-HSD) is lacking. Furthermore, it is not clear to what extent frequently occurring symptoms in these patients are related to their PA and sleep. Therefore, a cross-sectional study was performed to objectively evaluate, and identify factors contributing to, PA and sleep in adults with hEDS and G-HSD.Methods: Twenty female adults with hEDS, 23 with G-HSD, and 32 healthy controls participated. Physical activity and sleep were measured using two tri-axial ActiGraphs worn over seven consecutive days. Furthermore, questionnaires evaluating frequently occurring symptoms were completed. Regression analysis

Bone parameters in hypermobile Ehlers-Danlos syndrome and hypermobility spectrum disorder: A comparative cross-sectional study

“…As hypothesized, this study found no significant different body composition and bone parameters between individuals with hEDS and G-HSD. These findings confirm previous studies of our research group [3,13,21] and the studies of Copetti et al [22] and Hakim et al [23], showing no differences in symptoms and comorbidities between these two patient groups. Therefore, we once again suggest a supplementary classification, which classifies patients according to their comorbidities and symptoms, and which may better guide health practitioners in their clinical decisions [21].…”

“…Furthermore, due to higher risk of falling because of impaired balance, coordination and gait, and fear of (sub)luxating joints, it may be hypothesized that individuals with hEDS and G-HSD, avoid potential highrisk situations [17]. Accordingly, a previous study of our research group showed higher levels of kinesiophobia in individuals with hEDS and G-HSD [3].…”

“…Both hEDS and G-HSD are clinically characterized by chronic pain, fatigue, reduced physical activity and exercise, which may result in secondary impairment of bone parameters [3][4][5][6][7]. Additionally, decreased muscle strength and reduced force transmission due to reduced tendon stiffness may also have an impact on bone in hEDS and HSD [8,9].…”