Physical activity and sleep pattern in relation to incident Parkinson’s disease: a cohort study

Abstract

Background How physical activity (PA) and different sleep traits and overall sleep pattern interact in the development of Parkinson’s disease (PD) remain unknown. Objective To prospectively investigate the joint associations of PA and sleep pattern with risk of PD. Methods Included were 339,666 PD-free participants from the UK Biobank. Baseline PA levels were grouped into low (< 600 MET-mins/week), medium (600 to < 3000 MET-mins/week) and high (≥ 3000 MET-mins/week) according to the instructions of the UK Biobank. Healthy sleep traits (chronotype, sleep duration, insomnia, snoring, and daytime sleepiness) were scored from 0 to 5 and were categorized into “ideal sleep pattern” (≥ 3 sleep scores) and “poor sleep pattern” (0–2 sleep scores). Hazard ratios (HRs) and 95% confidence intervals (CIs) of PD were estimated by Cox proportional hazards models. Results During a median of 11.8 years of follow-up, 1,966 PD events were identified. The PD risk was lower in participants with high PA (HR = 0.73; 95% CI: 0.64, 0.84), compared to those with low PA; and participants with ideal sleep pattern also had a lower risk of PD (HR = 0.78; 95% CI: 0.69, 0.87), compared to those with poor sleep pattern. When jointly investigating the combined effect, participants with both high PA and ideal sleep pattern had the lowest risk of incident PD (HR = 0.55; 95% CI: 0.44, 0.69), compared to those with low PA and poor sleep pattern; notably, participants with high PA but poor sleep pattern also gained benefit on PD risk reduction (HR = 0.74; 95% CI: 0.55, 0.99). Conclusions Both high PA and ideal sleep pattern were independently associated with lower risk of developing PD, and those with both high PA level and ideal sleep pattern had the lowest risk. Our results suggest that improving PA levels and sleep quality may be promising intervention targets for the prevention of PD.

Association between dietary quality and accelerated aging: a cross-sectional study of two cohorts

“…Participants were categorized into groups of 7–8 hours and those with <7 or >8 hours of sleep per day based on their daily sleep duration. 21 DM and hypertension were determined based on participants’ self-reporting of physician-diagnosed conditions. In the NHANES cohort, depression screening utilized the Patient Health Questionnaire-9 (PHQ9) questionnaire, with scores of ≥10 indicating depression.…”

Research progress on the application of anti-gravity treadmill in the rehabilitation of Parkinson’s disease patients: a mini review

“…Research indicates that both physical activity levels and ideal sleep patterns are independently associated with a lower risk of PD, whereas individuals with high physical activity levels and ideal sleep patterns have the lowest risk of developing PD. Therefore, enhancing physical activity levels and sleep quality may be promising targets for intervention to prevent PD (72). A study noted that treadmill training increased cortical striatal neuroplasticity and dopamine release, thereby improving sleep quality (73).…”

Reply to: Association of accelerometer-measured physical activity intensity, sedentary time, and exercise time with incident Parkinson’s disease: need more evidence

“…Firstly, while sleep disturbances seem to be closely related to PD in observational studies 2 , 3 , there is no convincing evidence of any causal relationship of self-reported and objective sleep traits with the risk of PD in Mendelian randomization analysis 4 , 5 . However, genetic variants in Mendelian randomization analysis may not be an accurate substitute for sleep because genes can only account for a relatively small proportion of sleep phenotypic variation, and thus, the non-significant relationship may be attributed to insufficient statistical power.…”