Physical Activity and Weight Gain Throughout Pregnancy Are Associated With Umbilical Cord Markers

Everest, Catherine; Silva, Danilo F. da; Puranda, Jessica; Souza, Sara C S; Goudreau, Alexandra D.; Nagpal, Taniya S.; Edwards, Chris M.; Gupta, Rhea; Adamo, Kristi B.

doi:10.1016/j.jogc.2022.09.012

Cited by 2 publications

(2 citation statements)

References 26 publications

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“…Research has emphasized the positive health outcomes for offspring when their birthing parents embrace healthly habits during pregnancy [5,8]. For example, regular PA has been shown to decrease cord blood cholesterol levels in babies born to active and healthy gestational parents; thus, exercise is thought to influence the intrauterine environment [10]. Likewise, in offspring from parents who exercised during pregnancy, metabolites such as tyrosine and phenylalanine were increased while lactate decreased, suggesting an impact of PA on fetal amino acid metabolism [11].…”

Section: Introductionmentioning

confidence: 99%

Metabolomics to Understand Alterations Induced by Physical Activity during Pregnancy

da Silva,

Yadegari,

Tzaneva

et al. 2023

Metabolites

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Physical activity (PA) and exercise have been associated with a reduced risk of cancer, obesity, and diabetes. In the context of pregnancy, maintaining an active lifestyle has been shown to decrease gestational weight gain (GWG) and lower the risk of gestational diabetes mellitus (GDM), hypertension, and macrosomia in offspring. The main pathways activated by PA include BCAAs, lipids, and bile acid metabolism, thereby improving insulin resistance in pregnant individuals. Despite these known benefits, the underlying metabolites and biological mechanisms affected by PA remain poorly understood, highlighting the need for further investigation. Metabolomics, a comprehensive study of metabolite classes, offers valuable insights into the widespread metabolic changes induced by PA. This narrative review focuses on PA metabolomics research using different analytical platforms to analyze pregnant individuals. Existing studies support the hypothesis that exercise behaviour can influence the metabolism of different populations, including pregnant individuals and their offspring. While PA has shown considerable promise in maintaining metabolic health in non-pregnant populations, our comprehension of metabolic changes in the context of a healthy pregnancy remains limited. As a result, further investigation is necessary to clarify the metabolic impact of PA within this unique group, often excluded from physiological research.

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Section: Introductionmentioning

confidence: 99%

Metabolomics to Understand Alterations Induced by Physical Activity during Pregnancy

da Silva,

Yadegari,

Tzaneva

et al. 2023

Metabolites

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“…Contrary to popular social beliefs that physical activity in pregnancy could result in reduced fetal growth and development, no associations have been found with such factors [ 13 ]. In fact, being active throughout pregnancy has been shown to advance placenta blood perfusion [ 14 ], which can improve nutrient transport and overall placental function and therefore facilitate fetal development [ 15 ]. Furthermore, previous reviews have consistently advised that physical activity in pregnancy does not have adverse effects on fetal development [ 14 , 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

Influence of Physical Activity during Pregnancy on Birth Weight: Systematic Review and Meta-Analysis of Randomized Controlled Trials

Zhang,

Nagpal,

Silva-José

et al. 2023

JCM

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Birth weight is a marker that is often referred to determine newborn health, potential growth trajectories and risk of future disease. Accordingly, interventions to promote appropriate and healthy birth weight have been extensively studied and implemented in pregnancy. In particular, physical activity in pregnancy is recommended to promote appropriate fetal development and newborn birth weight. This systematic review and meta-analyses aimed to summarize the effect of physical activity during pregnancy specifically from randomized controlled trials on the following outcomes: birth weight, macrosomia, low birth weight, being large for the gestational age, and being small for the gestational age (Registration No.: CRD42022370729). 63 studies (16,524 pregnant women) were included. There was a significant negative relationship between physical activity during pregnancy and macrosomia (z = 2.16; p = 0.03; RR = 0.79, 95% CI = 0.63, 0.98, I2 = 29%, Pheterogeneity = 0.09). No other significant relationships were found. Promoting physical activity during pregnancy may be an opportune time to reduce the risk of future chronic disease, such as obesity, through the prevention of macrosomia and the promotion of appropriate birth weights.

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Physical Activity and Weight Gain Throughout Pregnancy Are Associated With Umbilical Cord Markers

Cited by 2 publications

References 26 publications

Metabolomics to Understand Alterations Induced by Physical Activity during Pregnancy

Metabolomics to Understand Alterations Induced by Physical Activity during Pregnancy

Influence of Physical Activity during Pregnancy on Birth Weight: Systematic Review and Meta-Analysis of Randomized Controlled Trials

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