Physical Activity and Worsening of Radiographic Findings in Persons With or at Higher Risk of Knee Osteoarthritis

Jayabalan, Prakash; Kocherginsky, Masha; Chang, Alison H.; Rouleau, Gerald W.; Koloms, Kimberly; Lee, Jung Hwa; Dunlop, Dorothy D.; Chang, Rowland W.; Sharma, Leena

doi:10.1002/acr.23756

Cited by 13 publications

(1 citation statement)

References 41 publications

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“…Another pathological factor in KOA is mechanical stress resulting from high physical activity of daily living or occupation (8-12). For example, prolonged or repeated squatting (8, 10, 11) and stressful stair climbing activity are considered risk factors for KOA (8,9,12), although a few groups have argued that high physical activity is not associated with the incidence or worsening of KOA (13,14).…”

Section: Introductionmentioning

confidence: 99%

Correlation of Knee Instability With Alignment And Repetitive Physical Activity In Patients With Knee Osteoarthritis: A Cross-Sectional Study

Wada¹,

Miyazaki²,

Yamamoto³

et al. 2021

Preprint

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Objectives. Malalignment, dynamic knee instability, and repetitive physical activity are considered biomechanical risk factors for knee osteoarthritis (KOA), though the correlations among these factors are poorly understood. The purpose of this study was to elucidate the relationship between knee instability and alignment, and to determine the effects of repetitive physical activity on knee instability in patients with KOA.Methods. The study subjects were 68 patients with radiographic tibiofemoral KOA and 68 control subjects. Each participant underwent clinical evaluation, muscle strength test, radiography, and knee instability test. Instability was evaluated before and after repetitive stepping exercise using triaxial accelerometer. Results. Mediolateral acceleration correlated (p<0.01) with two coronal alignments (mechanical axis; HKA and joint line convergent angle; JLCA). Pearson correlation coefficient was small (r=0.23-0.24) before but increased after stepping (r=0.28-0.33). Increased mediolateral acceleration after stepping correlated with JLCA (r=0.37, p<0.001) . There were significant differences in coronal alignments, gait speed, mediolateral acceleration, and accelerations in all directions between the control and KOA groups. Anteroposterior acceleration did not correlate with sagittal knee alignment. Multiple logistic regression analysis identified HKA/JLCA, and increased mediolateral acceleration after stepping as significant diagnostic predictors of KOA.Conclusion. We found a direct relationship between knee instability and knee alignment or repetitive physical activity. Repetitive stepping activity significantly increased mediolateral acceleration in KOA patients, compared to the control. Stepping increased the correlation between mediolateral acceleration and coronal alignment. In knees with large JLCA, repetitive stepping provided much larger mediolateral instability. Our results suggest that, in addition to JLCA, the increase in mediolateral acceleration after repetitive physical activity, possibly contributes to the development of KOA.Trial registrationTan-nan Regional Medical Center TRMC No. 2018-1

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Section: Introductionmentioning

confidence: 99%

Correlation of Knee Instability With Alignment And Repetitive Physical Activity In Patients With Knee Osteoarthritis: A Cross-Sectional Study

Wada¹,

Miyazaki²,

Yamamoto³

et al. 2021

Preprint

View full text Add to dashboard Cite

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Longitudinal Relationship Between Physical Activity and Joint Space Narrowing: Forty‐Eight–Month Follow‐Up Data From the Osteoarthritis Initiative

Han²,

Nevitt

et al. 2022

Arthritis Care & Research

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Objective. To determine whether the amount of physical activity (PA) is a determinant of joint space narrowing (JSN) worsening over 48 months in participants with knee osteoarthritis.Methods. Data were obtained from the Osteoarthritis Initiative. PA, measured using the Physical Activity Scale for the Elderly (PASE), was defined as the mean value of the annual measurements conducted prior to development of worsening JSN. Worsening JSN was defined as at least a partial grade increase in the Osteoarthritis Research Society International JSN score over 48 months, in comparison with baseline. Restricted cubic spline function was used to group participants based on the linear association between PA and JSN worsening. A pooled logistic regression model was used to evaluate the association between PA and JSN worsening adjusted for confounders.Results. A total of 2,167 participants were included. In total, 625 participants (28.8%) had JSN worsening over 48 months. Compared with a PASE score of 141-180, PASE scores of 101-140 and >220 were associated with an increased risk of JSN worsening in men, with odds ratios (ORs) of 1.73 (95% confidence interval [95% CI] 1.07-2.81) and 1.83 (95% CI 1.14-2.93), respectively. Similarly, in participants with Kellgren/ Lawrence (K/L) grade 2, compared with a PASE score of 141-180, PASE scores of ≤100 and >220 were associated with increased risks of JSN worsening, with an OR of 1.69 (95% CI 1.13-2.54) and 1.64 (95% CI 1.05-2.56), respectively.Conclusion. Compared to moderate PA, higher or lower amounts of PA are associated with an elevated risk for JSN worsening in men and in participants with K/L grade 2 knees.

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Knee joint unloading and daily physical activity associate with cartilage T2 relaxation times 1 month after ACL injury

Wellsandt

Kallman

Golightly

et al. 2021

Journal Orthopaedic Research

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Osteoarthritis (OA) is prevalent after anterior cruciate ligament (ACL) injury, but mechanismsunderlying its development are poorly understood. The purpose of this study was to determine if gait biomechanics and daily physical activity (PA) associate with cartilage T2 relaxation times, a marker of collagen organization and water content, 1 month after ACL injury. Twenty-seven participants (15-35 years old) without chondral lesions completed magnetic resonance imaging, threedimensional gait analysis, and 1 week of PA accelerometry. Interlimb differences and ratios were calculated for gait biomechanics and T2 relaxation times, respectively. Multiple linear regression models adjusted for age, sex, and concomitant meniscus injury were used to determine the association between gait biomechanics and PA with T2 relaxation times, respectively. Altered knee adduction moment (KAM) impulse, less knee flexion excursion (kEXC) and higher daily step counts accounted for 35.8%-65.8% of T2 relaxation time variation in the weightbearing and posterior cartilage of the medial and lateral compartment (all p ≤ .011). KAM impulse was the strongest factor for T2 relaxation times in all models (all p ≤ .001).

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Physical Activity and Worsening of Radiographic Findings in Persons With or at Higher Risk of Knee Osteoarthritis

Cited by 13 publications

References 41 publications

Correlation of Knee Instability With Alignment And Repetitive Physical Activity In Patients With Knee Osteoarthritis: A Cross-Sectional Study

Correlation of Knee Instability With Alignment And Repetitive Physical Activity In Patients With Knee Osteoarthritis: A Cross-Sectional Study

Longitudinal Relationship Between Physical Activity and Joint Space Narrowing: Forty‐Eight–Month Follow‐Up Data From the Osteoarthritis Initiative

Knee joint unloading and daily physical activity associate with cartilage T2 relaxation times 1 month after ACL injury

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