Physical activity as a mediator of anxiety and cognitive functioning in Parkinson's disease

Jones, Jacob D.; Timblin, Holly; Rahmani, Elizabeth; Garrett, Shania; Bunch, Joseph; Beaver, Halbert; Hill, Christopher R.

doi:10.1016/j.mhpa.2021.100382

Cited by 6 publications

(5 citation statements)

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“…PD patients with comorbid psychiatric complications may be at elevated risk for physical inactivity and subsequent complications. Indeed, other psychiatric complications such as anxiety and apathy are common in PD and associated with physical inactivity, cognitive impairment, and quality of life (Jones, Timblin, et al, 2021; Jones et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

“…Data from 10 national or international sites from were utilized in the current sample (see https://www.ppmi-info.org/about-ppmi/ppmi-clinical-sites for a complete list of sites). The sample has 100% (Jones, Dominguez, et al, 2021; Jones, Timblin, et al, 2021; Jones, Uribe, et al, 2021), 88% (Jones, Burroughs, et al, 2020; Jones, Rahmani, et al, 2020), and 64% (Jones et al, 2019) overlap with our past work. For additional details, please see Marek et al (2011) and https://www.ppmi-info.org/.…”

Section: Methodsmentioning

confidence: 97%

“…Past research provides evidence for physical inactivity, to be a behavioral pathway linking anxiety to cognitive impairment in PD or linking depression to cognitive impairment in healthy older adults (Jones, Timblin, et al, 2021; Sharifian et al, 2020). However, examining the associations between depression, physical activity, and cognition in PD is particularly relevant because (a) past research suggests that depression may be associated with future cognitive impairment above and beyond other mood symptoms (Jones et al, 2019) and (b) individuals with PD experience a variety of unique neurobiological (e.g., dopamine depletion and disruption of frontal-subcortical pathways important for both cognition and emotion) and psychosocial changes (e.g., embarrassment from motor symptoms, physical disability) that raise concerns about the extent that findings from healthy older adults generalize to the PD population.…”

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confidence: 99%

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Physical inactivity links depressive symptoms and cognitive functioning among individuals with Parkinson’s disease.

Timblin¹,

Rahmani²,

Ryczek³

et al. 2022

Neuropsychology

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Objective: Parkinson’s disease (PD) is a neurodegenerative disorder caused by disruption of dopamine-producing cells. PD is associated with motor symptoms and nonmotor symptoms including depression and cognitive impairment. Past research suggests an association between depression and cognitive impairment in PD. Physical activity may have a therapeutic effect on both depression and cognitive impairment. The present study investigates if physical activity mediates the association between depressive symptoms and cognition in a longitudinal sample of individuals with PD. Method: Participants include individuals newly diagnosed with PD (N = 487) enrolled in the Parkinson’s Progression Marker Initiative (PPMI). Participants completed an array of neuropsychological tests over the course of 5 years, as well as questionnaires of depression and physical activity. Between-person and within-person effects of depression and cognition mediated through physical activity were analyzed using structural equation modeling. Results: A significant direct effect demonstrated depression was associated with worse global cognitive functioning. Furthermore, there was a significant indirect within-person effect, indicating that physical activity fully mediated the association between depression and cognition. Individuals who became more depressed over time became less physically active and subsequently experienced cognitive decline over the 5-year period. Conclusions: Findings have implications for prognostic detection and/or the role of physical activity interventions to buffer effects of depression on cognitive impairment among individuals diagnosed with PD. Physical interventions may potentially be implemented among depressed persons to preserve cognitive functioning. Worsened depression early during PD may be a risk factor for inactivity and cognitive diminishment.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 97%

mentioning

confidence: 99%

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Physical inactivity links depressive symptoms and cognitive functioning among individuals with Parkinson’s disease.

Timblin¹,

Rahmani²,

Ryczek³

et al. 2022

Neuropsychology

Self Cite

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“…Another study focused on participants with recent Parkinson’s Disease diagnosis who were part of the Parkinson's Progression Marker Initiative (PPMI). The study results showed that having anxiety in the early part of the disease trajectory may lead to decreased engagement in physical activity and in turn, contribute to cognitive decline [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

Neuroticism, physical activity, and cognitive functioning in a population-based cohort of older adults

Desai,

Beck,

Krueger

et al. 2023

BMC Geriatr

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Background Little is known about how physical activity influences the relationship between neuroticism and cognitive function and cognitive decline. Methods Data from the Chicago Health and Aging Project (CHAP) was utilized to conduct this study. CHAP is a population-based cohort study of chronic conditions in older adults. Participants completed in-home interviews cycles of three years from 1993–2012. Mixed effects regression models were conducted to test the associations between physical activity, neuroticism, and the interaction between neuroticism and physical activity on outcomes: global cognitive function, global cognitive decline, episodic memory, decline in episodic memory, perceptual speed, and decline in perceptual speed. Stratified mixed effects regression models by physical activity level were conducted to test the associations between neuroticism and global cognitive function and global cognitive decline. Results A total of 7,685 participants were eligible for this study. Participants were 62% female and 64% African American. We found statistically significant associations for the interaction of high physical activity and neuroticism on baseline global cognitive function (β = 0.017 (SE = 0.007), p = .010) and on the interaction of neuroticism and high physical activity on baseline episodic memory (β = 0.020 (SE = .009), p = .021) and on decline in episodic memory over time (β = -0.003 (SE = .001), p = .039). Conclusion Higher physical activity lessened the association between higher neuroticism and poor cognitive outcomes.

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“…Study results showed that having anxiety in the early part of the disease trajectory may lead to decreased engagement in physical activity and in turn, contribute to cognitive decline. 22 However, the relationship between neuroticism and physical activity is complex. Healthy neuroticism is described as neuroticism interacting with conscientiousness.…”

Section: Discussionmentioning

confidence: 99%

Neuroticism, Physical Activity, and Cognitive Functioning in a Population-Based Cohort of Older Adults

Desai

Beck

Krueger

et al. 2023

Preprint

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Background. Little is known about how physical activity influences the relationship between neuroticism and cognitive function and cognitive decline.Methods. Data from the Chicago Health and Aging Project (CHAP) was utilized to conduct this study. CHAP is a population-based cohort study of chronic conditions in older adults. Participants completed in-home interviews cycles of three years from 1993–2012. Mixed effects regression models were conducted to test the associations between physical activity, neuroticism, and the interaction between neuroticism and global cognitive function and global cognitive decline. Stratified mixed effects regression models by physical activity level were conducted to test the associations between neuroticism and global cognitive function and global cognitive decline.Results. A total of 7,685 participants were eligible for this study. Participants were 62% female and 64% African American. We found statistically significant associations for the interaction of medium physical and neuroticism (β = 0.014 (SE = 0.007), p = .037) and the interaction of high physical activity and neuroticism (β = 0.021 (SE = 0.007), p = .003) on global cognitive function at baseline but not for decline over time. Stratified analysis showed that among participants with high physical activity levels, the association between neuroticism and global cognitive decline was statistically significant (β=-0.002 (SE = 0.001), p = .023).Conclusion. Increasing physical activity level benefits the cognitive functioning of individuals with high neuroticism. Interventions should incorporate health behavior change approaches which aim to reduce characteristics of neuroticism.

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Physical activity as a mediator of anxiety and cognitive functioning in Parkinson's disease

Cited by 6 publications

References 44 publications

Physical inactivity links depressive symptoms and cognitive functioning among individuals with Parkinson’s disease.

Physical inactivity links depressive symptoms and cognitive functioning among individuals with Parkinson’s disease.

Neuroticism, physical activity, and cognitive functioning in a population-based cohort of older adults

Neuroticism, Physical Activity, and Cognitive Functioning in a Population-Based Cohort of Older Adults

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