Physical activity as risk factor in amyotrophic lateral sclerosis: a systematic review and meta-analysis

Zheng, Xiaoting; Wang, Shichan; Huang, Jingxuan; Lin, Jing; Yang, Tianmi; Xiao, Yi; Jiang, Qirui; Huang, Rui; Li, Chunyu; Shang, Huifang

doi:10.1007/s00415-022-11555-4

Cited by 6 publications

(5 citation statements)

References 69 publications

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“…Indeed, recent studies evidenced that head impact exposure may increase the risk of neurodegenerative disease, in line with the observation that sports like soccer and football are those more linked to the development of ALS [78,79]. However, other recent studies showed that physical activity in general and other sports such as skiing may be associated with the risk of developing ALS [80][81][82]. Several putative mechanism have been hypothesized, ranging from oxidative stress to exercise-induced changes in neuron morphology [80].…”

Section: Environmental Factorsmentioning

confidence: 76%

Update on recent advances in amyotrophic lateral sclerosis

Riva,

Domi,

Pozzi

et al. 2024

J Neurol

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In the last few years, our understanding of disease molecular mechanisms underpinning ALS has advanced greatly, allowing the first steps in translating into clinical practice novel research findings, including gene therapy approaches. Similarly, the recent advent of assistive technologies has greatly improved the possibility of a more personalized approach to supportive and symptomatic care, in the context of an increasingly complex multidisciplinary line of actions, which remains the cornerstone of ALS management. Against this rapidly growing background, here we provide an comprehensive update on the most recent studies that have contributed towards our understanding of ALS pathogenesis, the latest results from clinical trials as well as the future directions for improving the clinical management of ALS patients.

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Section: Environmental Factorsmentioning

confidence: 76%

Update on recent advances in amyotrophic lateral sclerosis

Riva,

Domi,

Pozzi

et al. 2024

J Neurol

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“…Regular moderate-intensity training reduces oxidative stress, decreases inflammatory markers such as interleukin-6, and helps to preserve cardiovascular fitness and brain function ( 37 ). In contrast, strenuous, anaerobic physical activity is a risk factor for amyotrophic lateral sclerosis, as assessed by recent meta-analyses ( 38, 39 ). Though the risk rise (26% higher) is low in individuals with a history of vigorous physical activity, there is a five-fold mortality rate increase in professional athletes ( 39 ).…”

Section: Discussionmentioning

confidence: 99%

“…In contrast, strenuous, anaerobic physical activity is a risk factor for amyotrophic lateral sclerosis, as assessed by recent meta-analyses ( 38, 39 ). Though the risk rise (26% higher) is low in individuals with a history of vigorous physical activity, there is a five-fold mortality rate increase in professional athletes ( 39 ). Vigorous physical activity likely increases glutamate excitotoxicity and oxidative stress, hastening neurodegeneration in individuals with a genetic predisposition for the development of ALS ( 38 ).…”

Section: Discussionmentioning

confidence: 99%

Widespread drastic reduction of brain myelin content upon prolonged endurance exercise

Ramos-Cabrer,

Cabrera-Zubizarreta,

Padró

et al. 2023

Preprint

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Recent evidence suggests that myelin lipids may act as glial energy reserves when glucose is lacking, a hypothesis yet to be solidly proven. Hereby, we examined the effects of running a marathon on the myelin content by MRI. Our findings show that marathon runners undergo widespread robust myelin decrease at completion of the effort. This reduction involves white and gray matter, and includes primary motor and sensory cortical areas and pathways, as well as the entire corpus callosum and internal capsule. Notably, myelin levels partially recover within two weeks after the marathon. These results reveal that myelin use and replenishment is an unprecedented form of metabolic plasticity aimed to maintain brain function during extreme conditions.

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“…38,39 Though the risk rise (26% higher) is low in individuals with a history of vigorous physical activity, there is a ve-fold mortality rate increase in professional athletes. 39 Vigorous physical activity likely increases glutamate excitotoxicity and oxidative stress, hastening neurodegeneration in individuals with a genetic predisposition for the development of ALS. 38 Therefore, while the impact of marathon running in welltrained individuals is null, for those with ALS genetic risk, disease-vulnerable motor areas are impacted more by otherwise physiological myelin expenditure (e.g., corticospinal tract), as myelin itself and myelinproducing oligodendrocytes are also vulnerable to glutamate excitotoxicity.…”

Section: Discussionmentioning

confidence: 99%

“…37 In contrast, strenuous, anaerobic physical activity is a risk factor for amyotrophic lateral sclerosis, as assessed by recent meta-analyses. 38,39 Though the risk rise (26% higher) is low in individuals with a history of vigorous physical activity, there is a ve-fold mortality rate increase in professional athletes. 39 Vigorous physical activity likely increases glutamate excitotoxicity and oxidative stress, hastening neurodegeneration in individuals with a genetic predisposition for the development of ALS.…”

Section: Discussionmentioning

confidence: 99%

Widespread drastic reduction in brain myelin content upon marathon running

Ramos-Cabrer,

Cabrera-Zubizarreta,

Padró

et al. 2023

Preprint

View full text Add to dashboard Cite

Recent evidence suggests that myelin lipids may act as glial energy reserves when glucose is lacking, a hypothesis yet to be solidly proven. Hereby, we examined the effects of running a marathon on myelin content by MRI. Our findings show that marathon runners undergo widespread robust myelin decrease at completion of the effort. This reduction involves white and gray matter and includes primary motor and sensory cortical areas and pathways, as well as the entire corpus callosum and internal capsule. Notably, myelin levels partially recover within two weeks after the marathon. These results reveal that myelin use and replenishment is an unprecedented form of metabolic plasticity aimed at maintaining brain function during extreme conditions.

show abstract

Physical activity as risk factor in amyotrophic lateral sclerosis: a systematic review and meta-analysis

Cited by 6 publications

References 69 publications

Update on recent advances in amyotrophic lateral sclerosis

Update on recent advances in amyotrophic lateral sclerosis

Widespread drastic reduction of brain myelin content upon prolonged endurance exercise

Widespread drastic reduction in brain myelin content upon marathon running

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