Physical activity, body mass index and bone mineral density—associations in a prospective population-based cohort of women and men: The Canadian Multicentre Osteoporosis Study (CaMos)

Langsetmo, Lisa; Hitchcock, Caitlin; Kingwell, Elaine; Davison, K. Shawn; Berger, Claudie; Forsmo, Siri; Zhou, Wei; Kreiger, Nancy; Prior, Jerilynn C.

doi:10.1016/j.bone.2011.11.009

Cited by 115 publications

(98 citation statements)

References 30 publications

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“…In addition to DEXA, osteoporosis examination can be done with BMI [16]. Overweight and obesity have been considered protective to bone health, while higher BMI levels to be associated with higher BMD score [17][18][19][20]. In this study, the height and weight were positively correlated with BMD and the same result.…”

Section: Discussionsupporting

confidence: 50%

Analysis of Bone Mineral Density according to Hemoglobin in University Students

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김대중

성현호

et al. 2016

Korean J Clin Lab Sci.

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This study was performed to evaluate the effect of hemoglobin (Hb) on bone mineral density (BMD) in university students by performing a quantitative analysis. The subjects included healthy university students aged 20 to 30 years. Although osteoporosis has traditionally been considered as a disease of aging women, it is becoming an increasingly concerning male health problem. Diagnosis of osteoporosis is calculated with a quantitative assessment of BMD. Laboratory blood and urine tests are mainly used with low BMD or fragility fractures to identify any possible causes of bone metabolism disorders. In this study, there was no difference in BMD according to gender. The average red blood cell (RBC), Hb, and Hematocrit (HCT) were significantly higher in males (p＜0.01). The correlation between lumbar spine, skeletal muscle mass (SMM), and basal metabolic rate (BMR) was statistically significant (p＜0.01). Hb showed a 51.7% statistical influence on BMD by multiple regression analysis. These findings are useful to understand the relationship between BMD and Hb; lower Hb level is associated with lower BMD. The Hb level was the strongest predictor of abnormal BMD. In conclusion, this study showed that a low Hb value was significantly correlated with low bone mass, suggesting that a low Hb value is a risk factor for changes in bone turnover that leads to a decrease bone density.

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Section: Discussionsupporting

confidence: 50%

Analysis of Bone Mineral Density according to Hemoglobin in University Students

윤준

김대중

성현호

et al. 2016

Korean J Clin Lab Sci.

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“…However, the mean weight and BMI values of the two groups of patients did not differ significantly. Other studies have also shown an association between body weight (14,15) and BMI (1,11,22,(30)(31)(32)(33) with BMD. But, Saravi et al (4) reported no significant effect of BMI on BMD.…”

Section: Discussionmentioning

confidence: 87%

Age, Weight and Body Mass Index Effect on Bone Mineral Density in Postmenopausal Women

et al. 2014

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Background: Osteoporosis is a multifactorial skeletal disease, whose mechanisms are not fully understood. It is more common in older people, especially in postmenopausal women. Objectives: Body mass index (BMI) has been suggested as an important measurement to assess bone mineral density (BMD). Therefore, the aim of this study was to assess the effects of age, weight and BMI on BMD in postmenopausal women. Patients and Methods:In a cross-sectional study based on BMD measurement using dual-energy X-Ray Absorptiometry (DEXA) method, 80 postmenopausal women referred to Rheumatology Clinics in Zahedan were selected; 26 participants had osteoporosis, 28 had osteopenia, and 26 had normal bone density. Weight and height were obtained to calculate BMI. Results: The mean BMD of women older than 50 years compared to those younger than 50 years was significantly different (P < 0.05). The mean weight and BMI were found to be significantly lower in patients with low BMD as compared to the normal group (P < 0.0001). There was a negative significant association between age and low BMD only in femur neck region (r = -0.37, P = 0.006). In addition, a direct association was observed between weight (r = 0.41, P = 0.002) and BMI (r = 0.31, P = 0.02) with BMD at lumbar spine. Conclusions: The findings indicated that older women with low BMI were at higher risk of low bone mass. Body weight, BMI and aging may be important predictors of BMD, but they are not the only factors affecting bone loss. Therefore, it is recommended to assess other risk factors with a larger number of patients.

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“…Interpretation of areal BMD, an indicator of bone strength, is challenging in obese subjects, as it associates strongly with BMI and lean mass [2,3]. Despite high BMD, obese subjects have an increased risk of fractures, especially in lower extremities and peripheral sites [4][5][6].…”

Section: Introductionmentioning

confidence: 98%

Bone Characteristics and Their Determinants in Adolescents and Young Adults with Early-Onset Severe Obesity

et al. 2015

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Childhood obesity is associated with compromised bone health. We studied bone characteristics and their determinants in obese young adults. The study included 68 subjects with early-onset severe obesity and 73 normal-weight controls. Data on physical activity (PA), diet and smoking were collected. Bone characteristics were measured using peripheral QCT. The obese and control subjects were similar in age (mean 19.6 ± 2.6 years) and height but BMIs differed (39.7 and 22.6 kg/m(2)). A clustering of unhealthy lifestyles was marked: Obese subjects reported less supervised PA in childhood, adolescence and currently (p < 0.03) and were more likely to smoke (p = 0.005), and had a lower healthy eating index (HEI) (p = 0.007) but similar alcohol consumption compared with controls. In obese women, all crude bone characteristics were higher than in controls; in men, the differences were smaller. Associations of lifestyle factors with bone characteristics were tested using partial correlations. Independently of BMI, supervised PA in adolescence and alcohol consumption were related positively to bone characteristics in both groups. HEI associated positively with bone characteristics only in controls, while smoking was a positive determinant of bone characteristics only in obese subjects. The multivariate model showed that the contribution of lifestyle factors to bone characteristics was minimal compared with BMI. Early-onset obesity is accompanied by poor dietary quality, sedentary lifestyle, and more frequent smoking, but the overall contribution of these lifestyle factors to bone strength is limited. Bone strength is more likely to be compromised in men and in unloaded bone sites in subjects with early-onset severe obesity. The impact of obesity-related endocrine changes on bone characteristics need to be evaluated in future studies.

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Physical activity, body mass index and bone mineral density—associations in a prospective population-based cohort of women and men: The Canadian Multicentre Osteoporosis Study (CaMos)

Cited by 115 publications

References 30 publications

Analysis of Bone Mineral Density according to Hemoglobin in University Students

Analysis of Bone Mineral Density according to Hemoglobin in University Students

Age, Weight and Body Mass Index Effect on Bone Mineral Density in Postmenopausal Women

Bone Characteristics and Their Determinants in Adolescents and Young Adults with Early-Onset Severe Obesity

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