Physical activity counteracted associations of exposure to mixture of air pollutants with mitochondrial DNA copy number among rural Chinese adults

Li, Ruiying; Li, Shanshan; Pan, Mingming; Chen, Hao; Liu, Xiaotian; Chen, Gongbo; Chen, Ruoling; Yin, Shanshan; Hu, Kai; Mao, Zhenxing; Huo, Wenqian; Wang, Xian; Yu, Songcheng; Lee, Hyewon; Hou, Jian

doi:10.1016/j.chemosphere.2021.129907

Cited by 14 publications

(6 citation statements)

References 48 publications

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“…On the other hand, 3-y average exposure to

, and

measured in

grids was positively associated with mtDNA-CN in a rural Chinese population (

). 10 The different results of this study compared with our study may be due to differences in the duration and concentration of exposure, in the methods of mtDNA-CN assessment, in the population characteristics, or to increased variability in small samples.…”

Section: Discussioncontrasting

confidence: 69%

Long-Term Air Pollution Exposure and Mitochondrial DNA Copy Number: An Analysis of UK Biobank Data

Hong

Battle

Puiu

et al. 2023

Environ Health Perspect

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“…On the other hand, 3-y average exposure to

, and

measured in

grids was positively associated with mtDNA-CN in a rural Chinese population (

Section: Discussioncontrasting

confidence: 69%

Long-Term Air Pollution Exposure and Mitochondrial DNA Copy Number: An Analysis of UK Biobank Data

Hong

Battle

Puiu

et al. 2023

Environ Health Perspect

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“…A total of 3069 individuals were included, and 981 (31.96%) individuals diagnosed as carotid arteriosclerosis during the study were observed. At baseline, the median (IQR) age of the participants was 42 (34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46)(47)(48)(49) years. Nearly half of the participants were men (46.27%).…”

Section: Resultsmentioning

confidence: 99%

“…But the overall effect of multiple pollutants on carotid atherosclerosis cannot be interpreted, and high collinearity cannot be avoided. Quantile g-computation was presented to eliminate potential errors arising from collinearity by weighted method and obtain the total effect of multiple exposures [34,35].…”

Section: Introductionmentioning

confidence: 99%

Associations of Time-Weighted Individual Exposure to Ambient Particulate Matter with Carotid Atherosclerosis in Beijing, China

Han

Zhao

et al. 2022

Preprint

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Background Time-location information, including time spent indoors and outdoors around residential and work places and on commuting, physical activity, infiltrated ambient pollution and traffic transportations, was less considered estimating individual exposure to ambient pollution. Studies investigating the association between individual exposure to particulate matter (PM) with aerodynamic diameter <10 μm (PM10) and <2.5 μm (PM2.5) and carotid atherosclerosis obtained inconsistent results. Moreover, combined effect of mixed pollutants on carotid atherosclerosis was not fully explored because of high collinearity. We aimed to investigate the association between long-term individual time-weighted exposure to PM2.5 and PM10 and the risk of carotid atherosclerosis, and further explore the overall effects of multiple pollutants on carotid atherosclerosis. Methods Daily concentration of ambient pollutants was estimated by land-use regression model at both residential and work addresses, and 1-5 years’ time-weighted individual exposure was calculated by further considering personal activity pattern and infiltrated ambient pollution. We explored the association of PM2.5and PM10 with carotid atherosclerosis and pooled the overall effect of multiple pollutants by quantile g-computation. Results The significant association between time-weighted exposure to PM2.5 and PM10and carotid atherosclerosis was observed. Per interquartile range increase in 2-year exposure to PM2.5 (Hazard ratio (HR): 1.322, 95% confidence interval (CI): 1.219-1.434) and PM10 (HR:1.213, 95% CI: 1.116-1.319) showed the strongest association with carotid atherosclerosis, respectively. Individuals in higher quartiles of pollutants were at higher risk for carotid atherosclerosis. The linear and nonlinear relationships interpreted the upward trend of the risk for carotid atherosclerosis with increasing level of pollutant concentrations. Moreover, the overall adverse effects of multiple pollutants were further demonstrated. Conclusions Individual time-weighted exposure to PM2.5, PM10 and mixed pollutants was associated with carotid atherosclerosis. It is necessary to reduce individual pollutant exposure to inhibit the risk of carotid atherosclerosis and subsequently alleviate disease burdens of atherosclerotic diseases.

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“…The telomere repeat copy number, mtDNA-CN, and single-copy gene copy number were detected in triplicate with 15 ng of DNA by real-time polymerase chain reaction (QuantStudio TM 7 Flex, Applied Biosystems Life Technologies, USA) [28]. More detailed information on the primers of these genes has previously been reported [29,30] and is described in the Supplementary material. Finally, the relative TL or mtDNA-CN was computed by the average of the three telomere repeat copy number or mtDNA-CN measurements divided by the average of the three single-copy gene copy number measurements using the 2 − Ct method [31,32].…”

Section: Measurement Of Aging Biomarkersmentioning

confidence: 99%

Aging biomarkers: Potential mediators of association between long‐term ozone exposure and risk of atherosclerosis

Chen

Liu

et al. 2022

J Intern Med

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Background. Long-term exposure to ambient ozone links to aging biomarkers and increased risk for atherosclerotic cardiovascular diseases (ASCVD). However, the roles of aging biomarkers in the association of long-term exposure to ambient ozone with ASCVD are unclear. Methods.A total of 5298 participants completed the questionnaire and physical examination and provided biological specimens. Aging biomarkers (telomere length [TL] and mitochondrial copy number [mtDNA-CN]) were measured by using a real-time polymerase chain reaction method. The concentration of ambient ozone was assessed using a random forest model. Associations of ambient ozone or aging biomarkers with 10-year ASCVD risk were analyzed using logistic regression models. The roles of aging biomarkers in the association of ambient ozone exposure with 10-year ASCVD risk were explored by mediation analysis.Results. The adjusted odds ratios and 95% confidence interval of high 10-year ASCVD risk were 1.16 (1.08, 1.25), 0.71 (0.60, 0.85), and 0.78 (0.64, 0.96) in association with each 1-unit increment in ambient ozone (1 μg/m 3 ) concentration, relative TL, and mtDNA-CN, respectively. The mediated proportion of the association between ambient ozone exposure and high 10-year ASCVD risk by TL or mtDNA-CN was 21.13% or 7.75%, respectively. The total proportion of association between ambient ozone exposure and high 10-year ASCVD risk mediated by TL plus mtDNA-CN was 21.02%. Conclusions.Long-term exposure to ambient ozone was associated with increased 10-year ASCVD risk, and the association was partially mediated by aging biomarkers (shortened TL and decreased mtDNA-CN). This study indicated that ambient ozone pollution-related ASCVD risk might be partially explained by the telomere-mitochondrial axis of aging.

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Physical activity counteracted associations of exposure to mixture of air pollutants with mitochondrial DNA copy number among rural Chinese adults

Cited by 14 publications

References 48 publications

Long-Term Air Pollution Exposure and Mitochondrial DNA Copy Number: An Analysis of UK Biobank Data

Long-Term Air Pollution Exposure and Mitochondrial DNA Copy Number: An Analysis of UK Biobank Data

Associations of Time-Weighted Individual Exposure to Ambient Particulate Matter with Carotid Atherosclerosis in Beijing, China

Aging biomarkers: Potential mediators of association between long‐term ozone exposure and risk of atherosclerosis

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