Physical Activity, Depression, and Antiretroviral Therapy Adherence Among People Living With HIV: A Mediation Analysis

Bhochhibhoya, Amir; Qiao, Shan; Mao, Yuchen; Zhou, Yuejiao; Shen, Zhiyong; Sui, Xuemei; Li, Xiaoming

doi:10.1097/jnc.0000000000000045

Cited by 12 publications

(16 citation statements)

References 29 publications

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“…However, it is concerning that certain features of HIV self-management such as exercise and sleep are ranked high on this list. Exercise has been linked to mental health indicators such as decreased depressive symptoms and anxiety [ 22 ], increased quality of life [ 23 ], and increased ART adherence [ 24 ] in PLHIV. Similarly, poor sleep has been associated with increased depressive symptoms and anxiety, and decreased ART adherence [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

“…Greater affective symptoms and stress can lead to decreased HIV self-management and outcomes such as viral non-suppression. For instance, suboptimal ART adherence has been linked to depressive symptoms [ 24 , 26 , 27 ], anxiety [ 28 ], and stress [ 29 ]. Additionally, decreased retention in HIV care is associated with depressive symptoms [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

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The Impact of COVID-19 on HIV Self-Management, Affective Symptoms, and Stress in People Living with HIV in the United States

Wion

Miller

2021

AIDS Behav

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COVID-19 has the potential to detrimentally impact HIV self-management in people living with HIV (PLHIV). Effective HIV-self management is critically important in managing symptoms as well as viral suppression. We examined the impact of the COVID-19 pandemic on HIV self-management, social support, social isolation, depressive symptoms, anxiety, and stress in PLHIV. 85 PLHIV were recruited from social media sites and completed an online survey. Data were collected between April 23 and 30, 2020. Participants reported increases in social isolation, depressive symptoms, anxiety, and stress and decreases in social support and overall HIV self-management from pre- to during the pandemic. Additionally, the Social Support domain and Chronic Nature of HIV domain of the HIV Self-Management Scale were also decreased from pre- to during the pandemic. The ability for PLHIV to maintain HIV self-management during this time is essential and HIV care providers should have plans in place to provide support. Supplementary Information The online version contains supplementary material available at 10.1007/s10461-021-03335-4.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The Impact of COVID-19 on HIV Self-Management, Affective Symptoms, and Stress in People Living with HIV in the United States

Wion

Miller

2021

AIDS Behav

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“…This may eventually lead to social withdrawal/isolation, which in a sense informs why a higher prevalence of depression/mental disorders occur in PLWHA [ 42 – 44 ]. However, exercise ameliorates the symptoms of severe depression in PLWHA [ 45 ]. An epidemiological study showed that regular physical activity and depressive disorders are negatively related in adults [ 46 ].…”

Section: Introductionmentioning

confidence: 99%

Impact of exercise training on symptoms of depression, physical activity level and social participation in people living with HIV/AIDS: a systematic review and meta-analysis

et al. 2022

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Background Symptoms of depression are prevalent in people living with human immune deficiency virus/acquired immune deficiency syndrome (PLWHA), and worsened by lack of physical activity/exercises, leading to restriction in social participation/functioning. This raises the question: what is the extent to which physical exercise training affected, symptoms of depression, physical activity level (PAL) and social participation in PLWHA compared to other forms of intervention, usual care, or no treatment controls? Method Eight databases were searched up to July 2020, according to the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) protocol. Only randomised controlled trials involving adults who were either on HAART/HAART-naïve and reported in the English language, were included. Two independent reviewers determined the eligibility of the studies, extracted data, assessed their quality, and risk of bias using the Physiotherapy Evidence Database (PEDro) tool. Standardised mean difference (SMD) was used as summary statistics for the mean primary outcome (symptoms of depression) and secondary outcomes (PAL and social participation) since different measuring tools/units were used across the included studies. Summary estimates of effects were determined using a random-effects model (I2). Results Thirteen studies met the inclusion criteria with 779 participants (n = 596 participants at study completion) randomised into the study groups, comprising 378 males, 310 females and 91 participants with undisclosed gender, and with an age range of 18–86 years. Across the studies, aerobic or aerobic plus resistance exercises were performed 2–3 times/week, at 40–60 min/session, and for between 6-24 weeks, and the risk of bias vary from high to low. Comparing the intervention to control groups showed significant difference in the symptoms of depression (SMD = − 0.74, 95% confidence interval (CI) − 1.01, − 0.48, p ≤ 0.0002; I2 = 47%; 5 studies; 205 participants) unlike PAL (SMD = 0.98, 95% CI − 0.25, 2.17, p = 0.11; I2 = 82%; 2 studies; 62 participants) and social participation (SMD = 0.04, 95% CI − 0.65, 0.73, p = 0.91; I2 = 90%; 6 studies; 373 participants). Conclusion Physical exercise training could have an antidepressant-like effect in PLWHA but did not affect PAL and social participation. However, the high heterogeneity in the included studies, implies that adequately powered randomised controlled trials with clinical/methodological similarity are required in future studies. Trail Registration number INPLASY202040048.

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“…A study carried out in 2019 that aimed to analyze the relationship between physical activity, depression, and adherence to antiretroviral therapy among people with HIV infection, a significant relationship was found between physical activity and adherence to antiretroviral drugs, highlighting the importance of physical activity in disease management. 25 Our study was not addressed to analyze the impact of psychiatric diseases or self-esteem in adherence, but these disorders can have their impact attenuated by physical activity. 26 , 27 , 28 Whereas physical activity is designed to promote pleasurable and beneficial experiences, it can be considered an important element of a behavioral activation.…”

Section: Discussionmentioning

confidence: 99%

Medication adherence in systemic lupus erythematosus during Brazilian COVID-19 pandemic

Albuquerque

Pinto

Neto

et al. 2022

Lupus

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Background Patients with chronic diseases are potential candidates for inadequate follow-up of drug therapy, tending to incur damage to the intended results. This deserves greater attention in the pandemic period, as they are in the considered risk group. Methods We aim to assess Treatment Adherence Measure and analyze associations with characteristics related to the patient, treatment, disease, health professionals and service, and sociodemographic issues in patients with Systemic Lupus Erythematosus (SLE). W conducted a cross-sectional study with a sample of 116 participants, whose data were collected through individual interviews and review of medical records, during the first months of the COVID-19 pandemic in Brazil. Adherence was measured using the Treatment Adherence Measure, and associations were evidenced through described and inferential statistics. Results The percentage of adherent patients was 55.2%. An association was found between MTA (Medication Treatment Adherence) and physical exercise practice ( p = 0.032), and difficulties with treatment ( p = 0.002). Conclusion: Participants who did not practice physical exercise were 3.71 times more likely to not adhere to the treatment. Individuals who identified difficulties in the treatment were 3.43 times more likely to not adhere to the treatment; we believe that the pandemic may have influenced this result. More targeted studies are needed to measure the impact on MTA in these patients.

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Physical Activity, Depression, and Antiretroviral Therapy Adherence Among People Living With HIV: A Mediation Analysis

Cited by 12 publications

References 29 publications

The Impact of COVID-19 on HIV Self-Management, Affective Symptoms, and Stress in People Living with HIV in the United States

The Impact of COVID-19 on HIV Self-Management, Affective Symptoms, and Stress in People Living with HIV in the United States

Impact of exercise training on symptoms of depression, physical activity level and social participation in people living with HIV/AIDS: a systematic review and meta-analysis

Medication adherence in systemic lupus erythematosus during Brazilian COVID-19 pandemic

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