Physical Activity During Pregnancy Is Associated with Increased Placental FATP4 Protein Expression

Hutchinson, Kelly Ann; Vuong, Nhung; Mohammad, Shuhiba; Everest, Catherine; Leung, Macyn L; Bhattacharjee, J.; Adamo, Kristi B.

doi:10.1007/s43032-020-00210-w

Cited by 13 publications

(12 citation statements)

References 33 publications

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“…Noteworthily, this association was dependent on ST levels. By contrast, another study did not observe any association 29 . Methodological differences (e.g.…”

Section: Discussionmentioning

confidence: 84%

“…Given that most of the associations were reported with ST during early to middle gestation, a potential explanation is that reducing ST during this period might have induced diverse structural, metabolic and molecular changes in placental cells that remain throughout pregnancy until parturition, 28–30,43 and might dictate placental phenotype 5,20,28–30 . However, we cannot fully exclude that there might also be an acute influence of currently unknown drivers in later pregnancy that account for placental alterations.…”

Section: Discussionmentioning

confidence: 91%

“…However, there is a paucity of evidence about the influence of lifestyle on placental transporters and the underlying mechanisms. The few studies exploring this issue have shown that PA modulates the expression of placental molecules involved in glucose, fatty acid, amino acid and water transport, 28–30 and in insulin and mTOR signalling 30 . Nonetheless, these studies were limited to the middle period of gestation and by scarce sample size, and did not explore by which mechanisms ST or PA could alter the expression of placental genes or impact fetal health.…”

Section: Introductionmentioning

confidence: 99%

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The unexplored role of sedentary time and physical activity in glucose and lipid metabolism‐related placental mRNAs in pregnant women who are obese: the DALI lifestyle randomised controlled trial

Acosta‐Manzano

Leopold-Posch

Simmons

et al. 2021

BJOG

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Objective We aimed to explore: (i) the association of sedentary time (ST) and physical activity (PA) during pregnancy with the placental expression of genes related to glucose and lipid metabolism in pregnant women who are obese; (ii) maternal metabolic factors mediating changes in these placental transcripts; and (iii) cord blood markers related to the mRNAs mediating neonatal adiposity. Design Multicentre randomised controlled trial. Setting Hospitals in nine European countries. Population A cohort of 112 pregnant women with placental tissue. Methods Both ST and moderate‐to‐vigorous PA (MVPA) levels were measured objectively using accelerometry at three time periods during pregnancy. Main outcome measures Placental mRNAs (FATP2, FATP3, FABP4, GLUT1 and PPAR‐γ) were measured with NanoString technology. Maternal and fetal metabolic markers and neonatal adiposity were assessed. Results Longer periods of ST, especially in early to middle pregnancy, was associated with lower placental FATP2 and FATP3 expression (P < 0.05), whereas MVPA at baseline was inversely associated with GLUT1 mRNA (P = 0.02). Although placental FATP2 and FATP3 expression were regulated by the insulin–glucose axis (P < 0.05), no maternal metabolic marker mediated the association of ST/MVPA with placental mRNAs (P > 0.05). Additionally, placental FATP2 expression was inversely associated with cord blood triglycerides and free fatty acids (FFAs; P < 0.01). No cord blood marker mediated neonatal adiposity except for cord blood leptin, which mediated the effects of PPAR‐γ on neonatal sum of skinfolds (P < 0.05). Conclusions In early to middle pregnancy, ST is associated with the expression of placental genes linked to lipid transport. PA is hardly related to transporter mRNAs. Strategies aimed at reducing sedentary behaviour during pregnancy could modulate placental gene expression, which may help to prevent unfavourable fetal and maternal pregnancy outcomes. Tweetable abstract Reducing sedentary behaviour in pregnancy might modulate placental expression of genes related to lipid metabolism in women who are obese.

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“…Noteworthily, this association was dependent on ST levels. By contrast, another study did not observe any association 29 . Methodological differences (e.g.…”

Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The unexplored role of sedentary time and physical activity in glucose and lipid metabolism‐related placental mRNAs in pregnant women who are obese: the DALI lifestyle randomised controlled trial

Acosta‐Manzano

Leopold-Posch

Simmons

et al. 2021

BJOG

View full text Add to dashboard Cite

show abstract

“…The fetus cannot synthesize LA and ALA (i.e., the essential fatty acids), which can only be provided through placental transfer from the mother [43]. Indeed there is evidence suggesting that habitual exercise may be associated with higher activities of proteins/enzymes that enhance placental transfer of LA [44]. It is plausible that higher MVPA enhances the placental transfer of LA and/or other n-6 PUFA from maternal circulation into fetal circulation, subsequently resulting in lower LA in pregnant women.…”

Section: Discussionmentioning

confidence: 99%

Plasma Phospholipid n-3/n-6 Polyunsaturated Fatty Acids and Desaturase Activities in Relation to Moderate-to-Vigorous Physical Activity through Pregnancy: A Longitudinal Study within the NICHD Fetal Growth Studies

et al. 2020

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Maternal plasma phospholipid polyunsaturated fatty acids (PUFAs) play critical roles in maternal health and fetal development. Beyond dietary factors, maternal moderate-to-vigorous physical activity (MVPA) has been linked to multiple health benefits for both the mother and offspring, but studies investigating the influence of maternal MVPA on maternal PUFA profile are scarce. The objective of present study was to examine the time-specific and prospective associations of MVPA with plasma PUFA profile among pregnant women. This study included 321 participants from the National Institute of Child Health and Human Development (NICHD) Fetal Growth Studies–Singletons cohort. Maternal plasma phospholipid PUFAs and MPVA were measured at four visits during pregnancy (10–14, 15–26, 23–31, and 33–39 gestational weeks (GW)). Associations of maternal MVPA with individual plasma PUFAs and desaturase activity were examined using generalized linear models. Maternal MVPA was associated inversely with plasma phospholipid linoleic acid, gamma-linolenic acid, and Δ6-desaturase in late pregnancy (23–31 or 33–39 GW), independent of maternal age, race, education, parity, pre-pregnancy body mass index, and dietary factors. Findings from this longitudinal study indicate that maternal habitual MVPA may play a role on PUFAs metabolism, particular by alerting plasma n-6 subclass and desaturase activity in late pregnancy. These associations are novel and merit confirmation in future studies.

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“…Additionally, maternal exercise impacts placental gene expression to optimize fetal nutrient delivery and fetoplacental growth 55 56 57 . Those who performed strenuous exercise during pregnancy had increased T-type amino acid transporter 1 ( TAT1 ), neutral amino acid transporter A ( ASCT1 ), mitochondrial branched chain amino transferase ( mBCAT ), and glutamine sythetase ( GLUL ) placental expression indicating maternal exercise enhances amino acid transport pathways 58 .…”

Section: Exercise During Pregnancymentioning

confidence: 99%

Exercise during Pregnancy: Developmental Programming Effects and Future Directions in Humans

et al. 2021

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Epidemiological studies show that low birth weight is associated with mortality from cardiovascular disease in adulthood, indicating that chronic diseases could be influenced by hormonal or metabolic insults encountered in utero. This concept, now known as the Developmental Origins of Health and Disease hypothesis, postulates that the intrauterine environment may alter the structure and function of the organs of the fetus as well as the expression of genes that impart an increased vulnerability to chronic diseases later in life. Lifestyle interventions initiated during the prenatal period are crucial as there is the potential to attenuate progression towards chronic diseases. However, how lifestyle interventions such as physical activity directly affect human offspring metabolism and the potential mechanisms involved in regulating metabolic balance at the cellular level are not known. The purpose of this review is to highlight the effects of exercise during pregnancy on offspring metabolic health and emphasize gaps in the current human literature and suggestions for future research.

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Physical Activity During Pregnancy Is Associated with Increased Placental FATP4 Protein Expression

Cited by 13 publications

References 33 publications

The unexplored role of sedentary time and physical activity in glucose and lipid metabolism‐related placental mRNAs in pregnant women who are obese: the DALI lifestyle randomised controlled trial

The unexplored role of sedentary time and physical activity in glucose and lipid metabolism‐related placental mRNAs in pregnant women who are obese: the DALI lifestyle randomised controlled trial

Plasma Phospholipid n-3/n-6 Polyunsaturated Fatty Acids and Desaturase Activities in Relation to Moderate-to-Vigorous Physical Activity through Pregnancy: A Longitudinal Study within the NICHD Fetal Growth Studies

Exercise during Pregnancy: Developmental Programming Effects and Future Directions in Humans

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