Physical Activity, Growth, and Inflammatory Mediators in BMI-Matched Female Adolescents

Ischander, Mariam; Zaldivar, Frank; Eliakim, Alon; Nussbaum, Eliezer; Dunton, Genevieve F.; Leu, Szu-Yun; Cooper, Dan M.; Schneider, Margaret

doi:10.1249/mss.0b013e318053e7a2

Cited by 64 publications

(77 citation statements)

References 30 publications

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“…11,17 In addition, several of these studies did not control for body fat or CRF in their analyses, [27][28][29] or if they did so, the associations became attenuated or non-significant. 30,31 We also showed that CRF was inversely associated with CRP, C3 and C4.…”

Section: Modelmentioning

confidence: 99%

Associations of physical activity, cardiorespiratory fitness and fatness with low-grade inflammation in adolescents: the AFINOS Study

et al. 2010

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Objective: To examine the independent associations of objectively measured physical activity (PA), cardiorespiratory fitness (CRF) and fatness with low-grade inflammatory markers in adolescents. Design: Cross-sectional study in Spain. Subjects: A sample of 192 adolescents aged 13-17 years. Measurements: PA was assessed with an accelerometer for 7 days. A 20-m shuttle-run test was used to assess CRF. Skinfold thicknesses at six sites and WCs were measured. BMI was calculated from measured height and weight. C-reactive protein (CRP), interleukin-6 (IL-6) and complement factors C3 and C4 were assayed. The homeostasis model assessment of insulin resistance (HOMA-IR) was calculated from glucose and insulin. Regression analysis adjusted for potential confounders and HOMA-IR was used to determine the associations between PA, CRF and fatness with low-grade inflammatory markers. Results: Total PA, vigorous PA and MVPA were positively associated with CRF (r ¼ 0.25-0.48), whereas vigorous PA was negatively associated with skinfolds (r ¼ À0.27). CRF was inversely associated with fatness, (r ¼ À0.30 to À0.48). CRF and fatness were inversely and positively associated with HOMA-IR (r ¼ À0.16 and 0.21, respectively). PA variables were not independently associated with inflammatory markers. CRF and fatness were inversely and positively associated with CRP, C3 and C4, respectively. Only body fat explained a relevant amount of the variance of the model in CRP (4%) and C4 (19%), whereas CRP and body fat jointly explained the variance in C3 (25%). All these observations were independent of HOMA-IR. Conclusions: These findings support the key role of CRF and fatness on low-grade inflammation, as well as the possible indirect role of habitual PA through CRF and body fat in adolescents.

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Section: Modelmentioning

confidence: 99%

Associations of physical activity, cardiorespiratory fitness and fatness with low-grade inflammation in adolescents: the AFINOS Study

et al. 2010

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“…Intense and moderate exercises were also used 18,19,24,[30][31][32][33] planned exercises and sports games 29 and controlled exercises in exercise bike 31 besides sedentary behavior evaluation 20 . Longitudinal studies also assessed cardiorespiratory fitness by different methods: ergospirometry test 29 , 20 m shutle-run test 9 and cardiorespiratory test on exercise bike 32,33 . A study has used indirect calorimetry test for evaluating metabolic rate 19 .…”

Section: Resultsmentioning

confidence: 99%

“…A study has used indirect calorimetry test for evaluating metabolic rate 19 . It was observed that 10 articles were selected with cross-sectional design, among them, five showed a relationship between physical activity level, body composition and cardiometabolic markers 12,23,25,[32][33][34][35][36] ( Table 2). Two studies showed an association between sedentary behavior and cardiometabolic markers 25,34 .…”

Section: Resultsmentioning

confidence: 99%

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Effect of Physical Activity on Cardiometabolic Markers in Adolescents: Systematic Review

Miranda

Amorim

Oliveira

et al. 2016

Rev Bras Med Esporte

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The accumulation of body fat is a major risk factor for cardiometabolic diseases. Obesity can be considered a chronic systemic inflammatory disease in adults and younger people. The control of subclinical inflammation process through the practice of physical activity (PA) can mitigate the effects of risk factors that trigger atherosclerosis that worsens with advancing age. The objective of this study was to conduct a systematic review of the influence of physical activity and/or exercise on cardiometabolic markers and othrer risk factors of cardiovascular disease in adolescents. A systematic review was conducted in electronic databases Scopus, Pubmed, Conchrane Collection and SciELO. The terms used in the search were "cardiovascular diseases AND inflammation AND adolescents AND physical activity OR exercise". A total of 24 original articles were evaluated, being 14 longitudinal and 10 cross-sectional studies. Overall, 16 articles (66.66%) showed that PA, exercise and/or sedentary behavior may have influenced or have been related to the concentration of cardiometabolic markers. All studies that examined lifestyle changes showed reduction of cardiometabolic markers. Some limitations were observed: reduced samples, lack of dietary prescription, evaluation and control of volume and intensity of exercise. Most of the studies analyzed showed that the physical activity could influence and decrease the concentrations of cardiometabolic markers in adolescents. However, studies with representative sample size and precise control in assessing the level of physical activity and/or exercise are required to determine accurately the changes that the more active lifestyle can bring on inflammatory process, as well as other risk factors for cardiometabolic diseases in adolescents.

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“…low CTX/OC ratio) for both parity groups. This low CTX/OC ratio may be caused by a changed nutrient requirement, influences of dietary intake (increased from beginning to mid-gestation: 2.3 to 2.6 kg), skeletal replenishment or bone mass compensation in multiparous sows, and the increased activity during group housing, because it seems that exercise increases bone formation as has been found in humans (Ischander et al, 2007;Counotte et al, 2009).…”

Section: Discussionmentioning

confidence: 98%

Impact of parity on bone metabolism throughout the reproductive cycle in sows

Riet

Millet²,

Liesegang

et al. 2016

Animal

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Bone metabolism fluctuates throughout the reproductive cycle of sows to enable foetal growth and milk production. Although increased bone mineralisation is conceivable in sows during reproduction, a study of mineralisation in function of parity has not been performed. This study evaluated the fluctuations of markers for bone metabolism in primiparous and multiparous sows throughout a reproductive cycle. The experiment included ten multiparous and five primiparous commercial hybrid sows from one herd. The sows were monitored for one reproductive cycle and fed according to commercial dietary standards. Blood samples were taken in the morning before feeding at fixed time intervals before (day -5) and during gestation (insemination (day 0), 21, 42, 63, 84), around parturition (day 108, 112, parturition (115), 118), and during lactation (day 122, 129, 143). Serum osteocalcin (OC) concentration increased in early and mid-gestation ( P = 0.002) and decreased at the end of gestation ( P = 0.001), whereas crosslaps (CTX) concentration decreased during early and mid-gestation ( P = 0.002) and increased towards the end of gestation ( P = 0.001). Towards the end of lactation serum levels of both markers increased ( P = 0.007 and 0.013, respectively). For hydroxyproline (HYP) no significant fluctuation in function of the reproductive cycle was detected. Matrix metalloproteinase 2 (MMP2) concentration increased towards parturition for both primiparous and multiparous sows ( P = 0.001), whereas during lactation no significant fluctuations in function of the reproductive cycle were found. A parity effect was found for OC and CTX ( P < 0.010), but not for the other markers. These results demonstrate that bone metabolism differed between primiparous and multiparous sows, although in both groups a similar fluctuation throughout the reproductive cycle was observed.

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Physical Activity, Growth, and Inflammatory Mediators in BMI-Matched Female Adolescents

Cited by 64 publications

References 30 publications

Associations of physical activity, cardiorespiratory fitness and fatness with low-grade inflammation in adolescents: the AFINOS Study

Associations of physical activity, cardiorespiratory fitness and fatness with low-grade inflammation in adolescents: the AFINOS Study

Effect of Physical Activity on Cardiometabolic Markers in Adolescents: Systematic Review

Impact of parity on bone metabolism throughout the reproductive cycle in sows

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