Physical activity in adolescents with juvenile idiopathic arthritis

Lelieveld, Otto; Armbrust, Wineke; Leeuwen, van; Duppen, Nienke; Geertzen, Joannes; Sauer, Pieter J. J.; Weert, Ellen van

doi:10.1002/art.24102

Cited by 110 publications

(109 citation statements)

References 33 publications

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“…The link between fat area and reduced BMD remains unclear. As reported, 35 we may hypothesize that chronic systemic inflammation in JSLE may increase lipogenesis in nonadipose tissues and lipolysis in white adipose tissue, resulting in ectopic lipid deposition in nonadipose tissues, like muscle and liver. The production of proinflammatory cytokines characterizing an autoimmune disorder like SLE could be associated, on the one side, with an increased secretion of leptin and ectopic lipid accumulation in skeletal muscles, or on the other side with a higher bone turnover and consequent loss of bone mass.…”

Section: Discussionmentioning

confidence: 85%

Comparison of bone mass and quality determinants in adolescents and young adults with juvenile systemic lupus erythematosus (JSLE) and juvenile idiopathic arthritis (JIA)

Stagi

Cavalli

Bertini

et al. 2014

Lupus

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Background Few prospective data have been published on the comparison of bone density and quality in homogeneous groups of patients with juvenile systemic lupus erythematosus (JSLE) and juvenile idiopathic arthritis (JIA). Objective and hypothesis The objective of this study is to perform a longitudinal evaluation of the prevalence and the characteristics of bone mass and quality and to evaluate the differences on the bone parameters, using DXA, pQCT and QUS. Population and/or methods Forty-three JSLE patients (35 females, 8 males, median age 18.8, range 14.0–34.1 years) have been studied with DXA, pQCT and QUS scans and compared with 138 JIA patients (112 females, 26 males, median age 18.9, range 13.4–33.2 years), and 79 controls (59 females, 20 males; median age 19.3, range 13.5–36.5 years). Of these, 39 patients (32 females and 7 males, median age 20.3, range 16.6–36.8 years) with JSLE were followed longitudinally and compared with 131 patients (108 females, 23 males median age 20.7, range 15.8–37.1 years) with JIA and 63 controls (48 females, 15 males; median age 21.9, range 15.5–38.3 years). Results JSLE patients have a higher bone cortical density (CrtBMD) than controls and JIA patients ( p < 0.005). However, JSLE and JIA patients have a significantly reduced bone trabecular density (TrbBMD) compared to controls ( p < 0.0001), with no differences between JSLE and JIA. In addition, JIA patients show a significantly reduced muscle area (MuscleCSA) compared to JSLE and controls ( p < 0.001). Conversely, fat area (FatCSA) is significantly increased both in JIA and JSLE patients when compared to controls ( p < 0.001), with no differences between the JSLE and JIA groups. Analogous results are observed in the polar resistance to stress (SSIp). On longitudinal evaluation, contrary to CrtBMD, the difference between BMAD SDS, TrbBMD, MuscleCSA and FatCSA remains unchanged; in JSLE patients, SSIp is stable in comparison to JIA and controls without any difference between the two groups. Conclusions The evaluation of bone density and structure parameters in JSLE patients highlights significant differences compared with JIA patients and controls. These data might indicate a different pathogenesis of bone damage in the two entities, and suggest a different diagnostic and therapeutic approach to improve the peak bone mass.

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Section: Discussionmentioning

confidence: 85%

Comparison of bone mass and quality determinants in adolescents and young adults with juvenile systemic lupus erythematosus (JSLE) and juvenile idiopathic arthritis (JIA)

Stagi

Cavalli

Bertini

et al. 2014

Lupus

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“…In other studies, physical disability also appears to be strongly related to HRQOL (14,16,22,39). Besides, physical activity is generally impaired in adolescents with JIA (40). Individualized training programs may significantly improve the physical ability of the adolescent (41) and therefore positively influence a child's HRQOL.…”

mentioning

confidence: 85%

Predictors of health‐related quality of life in children and adolescents with juvenile idiopathic arthritis: Results from a web‐based survey

Haverman¹,

Grootenhuis²,

M³

et al. 2012

Arthritis Care & Research

115

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Objective. Children with juvenile idiopathic arthritis (JIA) experience functional impairment due to joint manifestations of the disease. The aim of our present study was to assess health-related quality of life (HRQOL) and its predictors in a group of children and adolescents with JIA. Methods. The study sample includes all JIA patients (ages 6 -18 years) who consulted a pediatric rheumatologist in Amsterdam, The Netherlands, between February 2009 and March 2010. HRQOL was measured using the Paediatric Quality of Life Inventory 4.0 (ages 6 -18 years). Functional ability was measured using the Childhood Health Assessment Questionnaire, and medical and sociodemographic parameters were assessed. The study sample was compared to a Dutch youth norm population including children with other chronic health conditions. The proportion of children with JIA with an impaired HRQOL (<1 SD) was evaluated and multivariate regression analyses were performed to predict HRQOL outcome. Results. Of the eligible patients, 64.1% (n ‫؍‬ 152) participated. Both children (ages 6 -12 years) and adolescents (ages 13-18 years) with JIA reported a significantly lower HRQOL in almost all domains compared to either healthy controls or children with other chronic health conditions. Approximately half of the children with JIA showed an impaired HRQOL. The main predictors of HRQOL were functional ability, pain, subjective burden of medication use, and school absence. Conclusion. The HRQOL is severely affected in children and adolescents with JIA. These findings underline the necessity to systematically monitor HRQOL in daily clinical practice.

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“…Most recently, Lelieveld et al 48 measured physical activity levels and energy expenditure in 30 adolescents with JIA (mean age 17, CHAQ 0 . 5) compared to 106 age-matched controls.…”

Section: Resultsmentioning

confidence: 98%

A review of the physical activity levels of children with juvenile arthritis

Condon

Gormley

Hussey

2009

Physical Therapy Reviews

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Background: Juvenile idiopathic arthritis (JIA) is a chronic disease characterised by synovial inflammation that may lead to permanent joint damage. Children with JIA may experience periods of reduced physical activity during an exacerbation of the disease and possibly after the active inflammation has resolved. The objective of this review was to establish the current physical activity levels in children with JIA. Methods: A literature search was performed to examine the evidence surrounding physical activity levels in children with JIA. For inclusion in the review, studies had to measure and report levels of physical activity with either objective or subjective methods. Results: Seven studies meeting the criteria were reviewed. A limited number of studies used objective measurements of physical activity, such as accelerometers. The results of these studies suggest that there is little difference in physical activity levels between children with JIA and controls. Studies that used subjective measurements such as self-reported or parental-reported questionnaires suggest a decline in physical activity in the subjects with JIA compared to controls. Discussion: Due to the conflicting nature of the results and methodological issues in some of studies reviewed, it is not clear if there is a significant difference in physical activity levels in children with JIA compared to healthy peers. Given the known benefits of physical activity on the musculoskeletal and cardiorespiratory systems during childhood, further research in this area is required to assess physical activity levels in children with JIA.

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Physical activity in adolescents with juvenile idiopathic arthritis

Cited by 110 publications

References 33 publications

Comparison of bone mass and quality determinants in adolescents and young adults with juvenile systemic lupus erythematosus (JSLE) and juvenile idiopathic arthritis (JIA)

Comparison of bone mass and quality determinants in adolescents and young adults with juvenile systemic lupus erythematosus (JSLE) and juvenile idiopathic arthritis (JIA)

Predictors of health‐related quality of life in children and adolescents with juvenile idiopathic arthritis: Results from a web‐based survey

A review of the physical activity levels of children with juvenile arthritis

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