Physical activity in hypertrophic cardiomyopathy: prevalence of inactivity and perceived barriers

Sweeting, J.; Ingles, Jodie; Ball, Kylie; Semsarian, C.

doi:10.1016/j.hlc.2015.06.644

Cited by 11 publications

(23 citation statements)

References 5 publications

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“…19 Sweeting et al similarly reported that only 13% of adults diagnosed with hypertrophic cardiomyopathy were meeting the minimum recommendation of 150 min/week of moderate-to vigorous-intensity physical activity. 22 Research has shown that decreased cardiorespiratory fitness is a strong independent predictor of cardiovascular disease and all-cause mortality later in life. 23 This raises the concern that decreased moderateto vigorous-intensity physical activity may help protect this patient population from arrhythmogenic events but may increase the risk of other adverse health outcomes later in life.…”

Section: Discussionmentioning

confidence: 99%

The impact of physical activity modification on the well-being of a cohort of children with an inherited arrhythmia or cardiomyopathy

et al. 2020

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Background:We evaluated a cohort of 35 children diagnosed with long QT syndrome, catecholaminergic polymorphic ventricular tachycardia, hypertrophic cardiomyopathy, or arrhythmogenic right ventricular cardiomyopathy with regard to physical and psychosocial well-being.Material and Methods:Patients wore an accelerometer to record their time involved in moderate- to vigorous-intensity physical activity and completed the Pediatric Quality of Life Inventory and the Pediatric Cardiac Quality of Life Inventory. Parents were also asked to describe if their child had changed their physical activity because of their diagnosis and how difficult and upsetting it was for the child to adapt to the physical activity recommendations.Results:Patients were involved in less moderate- to vigorous-intensity physical activity per day (35 min/day versus 55 min/day) and had lower Pediatric Quality of Life Inventory total health scores (79 versus 84) compared to normative data. Overall, 51% of the cohort modified their physical activity in some way because of their diagnosis and changing physical activity was associated with lower Pediatric Quality of Life Inventory and Pediatric Cardiac Quality of Life Inventory scores.Conclusion:Our cohort was involved in less moderate- to vigorous-intensity physical activity and had lower Pediatric Quality of Life Inventory total health scores compared to normative paediatric data. Modifying one’s physical activity was associated with worse health-related quality of life scores, highlighting a vulnerable sub-group of children. These findings are useful for families and healthcare professionals caring for children who are adjusting to a new cardiac diagnosis of an inherited arrhythmia or cardiomyopathy.

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Section: Discussionmentioning

confidence: 99%

The impact of physical activity modification on the well-being of a cohort of children with an inherited arrhythmia or cardiomyopathy

et al. 2020

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“…; Sweeting et al . ). While this important lifestyle change may reduce the risk of incident ventricular arrhythmia, it comes at the potential cost of a sedentary lifestyle with the sequelae of weight gain, hypertension, hyperlipidaemia, insulin resistance, coronary artery disease, and increased morbidity and mortality (Morris et al .…”

Section: Introductionmentioning

confidence: 97%

Catecholamine response to exercise in patients with non‐obstructive hypertrophic cardiomyopathy

Shah

Bechis

Brown

et al. 2019

The Journal of Physiology

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Key pointsr Intense physical activity, a potent stimulus for sympathetic nervous system activation, is thought to increase the risk of malignant ventricular arrhythmias among patients with hypertrophic cardiomyopathy (HCM).r As a result, the majority of patients with HCM deliberately reduce their habitual physical activity after diagnosis and this lifestyle change puts them at risk for sequelae of a sedentary lifestyle: weight gain, hypertension, hyperlipidaemia, insulin resistance, coronary artery disease, and increased morbidity and mortality.r We show that plasma catecholamine levels remain stably low at exercise intensities below the ventilatory threshold, a parameter that can be defined during cardiopulmonary exercise testing, but rise rapidly at higher intensities of exercise.r These findings suggest that cardiopulmonary exercise testing may be a useful tool to provide an individualized moderate-intensity exercise prescription for patients with HCM.Abstract Intense physical activity, a potent stimulus for sympathetic nervous system activation, is thought to increase the risk of malignant ventricular arrhythmias among patients with hypertrophic cardiomyopathy (HCM). However, the impact of exercise intensity on plasma catecholamine levels among HCM patients has not been rigorously defined. We conducted a prospective observational case-control study of men with non-obstructive HCM and age-matched controls. Laboratory-based cardiopulmonary exercise testing coupled with serial phlebotomy was used to define the relationship between exercise intensity and plasma catecholamine levels. Compared to controls (C, n = 5), HCM participants (H, n = 9) demonstrated higher left ventricular mass index (115 ± 20 vs. 90 ± 16 g/m 2 , P = 0.03) and maximal left ventricular wall thickness (16 ± 1 vs. 8 ± 1 mm, P < 0.001) but similar body mass index, resting heart rate, peak oxygen consumption (H = 40 ± 13 vs. C = 42 ± 7 ml/kg/min, P = 0.81) and heart rate at the ventilatory threshold (H = 78 ± 6 vs. C = 78 ± 4% peak heart rate, P = 0.92).

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“…Because of widely debated historical concerns about elevated sudden cardiac death risk associated with vigorous exercise in athletic individuals (12)(13)(14)(15), patients with HCM often limit their physical activity, which can, in turn, lead to other complications, such as obesity and depression (16)(17)(18)(19)(20). Patients with HCM have reduced exercise capacity and cardiorespiratory tness (21), which have been shown to be independent predictors of early mortality from heart failure and sudden cardiac death as well as disease progression (22)(23)(24)(25).…”

Section: Introductionmentioning

confidence: 99%

Patient experiences with obstructive and nonobstructive hypertrophic cardiomyopathy: a conceptual model of symptoms and impacts on quality of life

Zaiser

Sehnert

Duenas

et al. 2020

Preprint

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Background Hypertrophic cardiomyopathy (HCM) is a primary myocardial disorder defined by left ventricular hypertrophy that cannot be explained by another cardiac or systemic disease. There is a general lack of knowledge about patients’ perspectives on the symptoms and day-to-day limitations they experience as a result of HCM. We therefore sought an in-depth understanding of patients’ experiences of obstructive (oHCM) and nonobstructive (nHCM) forms of the disease, including symptoms and their quality of life impacts, and to develop a conceptual model to capture them. Methods Development of the HCM conceptual model involved a web-based survey to capture patients’ insights, a targeted literature review (which included relevant guidelines and patient advocacy websites), one-to-one interviews with clinical experts, and one-to-one qualitative concept elicitation interviews with patients. Key symptoms and their impacts most important to patients’ experiences were identified and used to develop a conceptual model of the patient experience with HCM. Results The HCM symptoms reported by patient interviewees (n = 27) were largely consistent with findings from the patient web survey (n = 444), literature review, and interviews with three expert clinicians. The symptoms most commonly reported in patient interviews included tiredness (89%), shortness of breath (89%), shortness of breath with physical activity (89%), and dizziness/light-headedness (89%). Other symptoms commonly reported included chest pain (angina) (70%), chest pain (angina) with physical exertion (70%), and palpitations (fluttering or rapid heartbeat) (81%). The most commonly reported impacts of HCM symptoms on patients’ lives included limitations to physical activities (78%), emotional impacts, including feeling anxious or depressed (78%), and impacts on work (63%). Symptoms and impacts were similar for both oHCM and nHCM. Conclusions A conceptual model was developed, which identifies the core symptoms that patients with oHCM and nHCM reported as most frequent and most important: shortness of breath, palpitations, fatigue/tiredness, dizziness/light-headedness, and chest pain, as well as the impacts those symptoms have on patients’ lives. This HCM conceptual model reflecting patients’ experiences and perspectives was used in the development of a patient-reported outcomes instrument for use in clinical trials and it may also help inform the clinical management of HCM.

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Physical activity in hypertrophic cardiomyopathy: prevalence of inactivity and perceived barriers

Cited by 11 publications

References 5 publications

The impact of physical activity modification on the well-being of a cohort of children with an inherited arrhythmia or cardiomyopathy

The impact of physical activity modification on the well-being of a cohort of children with an inherited arrhythmia or cardiomyopathy

Catecholamine response to exercise in patients with non‐obstructive hypertrophic cardiomyopathy

Patient experiences with obstructive and nonobstructive hypertrophic cardiomyopathy: a conceptual model of symptoms and impacts on quality of life

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