Physical activity in young children is reduced with increasing bronchial responsiveness

Brasholt, Martin; Baty, Florent; Bisgaard, Hans

doi:10.1016/j.jaci.2010.02.002

Cited by 33 publications

(50 citation statements)

References 38 publications

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“…As a consequence, obesity could be associated with a specific asthma phenotype (specific pathophysiology) [26] and/or with a worsening of asthma (worse control) [27], although these findings are under debate [28]. However, in line with these findings, young children with decreased physical activity, which favours the overweight condition, showed increased airway responsiveness [29], and children with a persistently high BMI during childhood or a high BMI at age 6-7 yrs were significantly at risk of dyspnoea and of airway hyperreactivity at age 8 yrs [30]. Unfortunately, we have no data on child fitness or physical activity in our study.…”

Section: Discussionmentioning

confidence: 87%

Overweight is not a comorbidity factor during childhood asthma: the GrowthOb study

Mahut

Beydon²,

Delclaux³

2011

Eur Respir J

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While being overweight is a risk factor for subsequent asthma in children, the importance of body mass index (BMI) as a comorbidity factor remains debated. The aim of this study was to assess the relationships between being overweight and the characteristics of childhood asthma.The BMI, BMI z-scores and International Obesity Task Force (IOTF) grades were evaluated in asthmatic children according to atopic status, symptoms during the past 3 months, exercise breathlessness, treatment and lung function in 6-15-yr-old children with confirmed asthma.491 asthmatic children (mean¡SD age 10.8¡2.6 yrs; 179 females) were prospectively enrolled. There were 78 (15.5%) overweight (IOTF grade 1) and eight (1.6%) obese (grade 2) children. The children's BMI z-scores did not differ according to atopy, exacerbation, symptom-free days or treatment. The BMI z-score correlated positively with forced vital capacity and forced expiratory volume in 1 s in females, which could be related to earlier puberty in overweight females (growth spurt with increased volumes). Compared with normal weight children, overweight and obese children had reduced lung volume ratios (functional residual capacity/total lung capacity (TLC) and residual volume/TLC), no evidence of airflow limitation and similar symptoms.In conclusion, the observed functional relationships with BMI are not specific to asthma and being overweight is not associated with significant clinical impacts on asthma during childhood.KEYWORDS: Body mass index, lung function, lung volumes, obesity, z-score I n the paediatric population, an increase in body mass index (BMI) is associated with the increased incidence [1] and prevalence [2] of asthma. The role of being overweight as a comorbidity factor is said to be ''possibly important, yet poorly studied '' [3]. Conflicting results on the relationship between BMI and asthma phenotype have been published. Being overweight has been associated with the severity of asthma exacerbations [4,5], as well as with poor asthma control [6]. However, in an important retrospective study, no effect of BMI on the time required to achieve control of asthma or on the ability to maintain good control of asthma was shown [7]. BMI per se has also been inconsistently correlated with clinical symptoms, such as coughing and wheezing on exertion [8], and with an increase in the number of symptom days and in the number of exacerbations in females only [9]. Such discrepancies between results might partially be due to the various cut-off points of BMI that are used across studies to define overweight and obesity (frequently the 85th or 95th percentiles). Normal values of BMI are age-and sex-specific throughout childhood; therefore, the transformation of children's BMI values into sex-and age-specific zscores is mandatory in order to ascertain the relationships between stoutness and clinical events and lung function. To further study the effect of overweight/obesity during childhood, the grades of COLE and co-workers [10,11] of the International Obesity Ta...

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Section: Discussionmentioning

confidence: 87%

Overweight is not a comorbidity factor during childhood asthma: the GrowthOb study

Mahut

Beydon²,

Delclaux³

2011

Eur Respir J

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“…Physical activity level was registered at 5 y (range 4-7) and expressed as counts/min, previously described in detail (36).…”

Section: Dxa Scanningmentioning

confidence: 99%

Polyunsaturated fatty acid content of mother’s milk is associated with childhood body composition

et al. 2012

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“…This may cause them to avoid physical activity, leading to deconditioning and poor cardiorespiratory fitness [2,3]. …”

Section: Introductionmentioning

confidence: 99%

Feasibility of high-intensity training in asthma

Toennesen

Soerensen

Hostrup

et al. 2018

European Clinical Respiratory Journal

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Background: High-intensity interval training is an effective and popular training regime but its feasibility in untrained adults with asthma is insufficiently described. Objective: The randomized controlled trial ‘EFFORT Asthma’ explored the effects of behavioural interventions including high-intensity interval training on clinical outcomes in nonobese sedentary adults with asthma. In this article we present a sub analysis of data aiming to evaluate if patients’ pre-intervention levels of asthma control, FEV1, airway inflammation and airway hyperresponsiveness (AHR) predicted their training response to the high-intensity interval training program, measured as increase in maximal oxygen consumption (VO2max). Design: We used data from the EFFORT Asthma Study. Of the 36 patients randomized to the 8-week exercise intervention consisting of high-intensity training three times per week, 29 patients (45% females) completed the study and were included in this data analysis. Pre-intervention assessment included the asthma control questionnaire (ACQ), spirometry, fractional exhaled nitric oxide (FeNO) and AHR to mannitol. VO2 max was measured during an incremental cycle test. Results: The majority of included patients had partly or uncontrolled asthma reflected by a mean (SD) ACQ at 1.7 (0.6). Median (IQR) FeNO was 28.5 (23.8) ppb and 75% had a positive mannitol test indicating AHR.The association between patients’ training response measured as increase in VO2max and pre-intervention ACQ scores was not statistically significant (p = 0.49). Likewise, the association between patients’ increase in VO2max and FeNO as well as AHR was not statistically significant (p = 0.80 and p = 0.58). Conclusions: Included asthma patients could adhere to the high-intensity interval protocol and improve their VO2max regardless of pre-intervention levels of asthma control, airway inflammation and AHR.

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Physical activity in young children is reduced with increasing bronchial responsiveness

Cited by 33 publications

References 38 publications

Overweight is not a comorbidity factor during childhood asthma: the GrowthOb study

Overweight is not a comorbidity factor during childhood asthma: the GrowthOb study

Polyunsaturated fatty acid content of mother’s milk is associated with childhood body composition

Feasibility of high-intensity training in asthma

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