Physical activity is inversely associated with microalbuminuria in hypertensive patients at high cardiovascular risk: data from I-SEARCH

Pöss, Janine; Ukena, Christian; Mahfoud, Felix; Gensch, Christoph; Werner, Carsten; Thoenes, Martin; Bramlage, Peter; Volpe, Massimo; Laufs, Ulrich; Böhm, Michael

doi:10.1177/1741826711421301

Cited by 8 publications

(6 citation statements)

References 46 publications

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“…MAU is closely related to some CVD risk factors including age, smoking, hypertension, diabetes, dyslipidaemia and lack of physical activity. 25,26 MAU is associated with impaired arterial and venous endothelium-dependent vasodilation in patients with Type 2 DM. 27–29…”

Section: Discussionmentioning

confidence: 97%

Evaluation of the point of care Afinion AS100 analyser in a community setting

et al. 2016

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Background A 'one stop shop' model for multifactorial risk factor management in a culturally sensitive environment may improve cardiovascular disease and diabetes prevention. A full biochemical profile for cardiovascular disease risk assessment includes a lipid profile, glucose, glycated haemoglobin and urine albumin creatinine ratio measurements. This may require the use of more than one point of care testing instrument. Methods Individuals who attended a community cardiovascular disease risk screening or an audit programme of the diabetic care pathway in the community were sampled. Bland-Altman and Deming regression plots were used to assess agreement between methods for total cholesterol, high-density lipoprotein cholesterol, triglycerides, glycated haemoglobin and urine albumin creatinine ratio. Results There was good agreement between the Afinion AS100 analyser, Cholestech LDX and the laboratory methods for total cholesterol, high-density lipoprotein cholesterol and triglycerides ( n = 232). The Afinion AS100 agreed well with the laboratory method for glycated haemoglobin ( n = 255) and urine albumin creatinine ratio ( n = 176). There was statistically significant bias ( p = 0.03 to <0.0001) for several measurements. However, these were judged not to be clinically relevant. Specifically for the total cholesterol and high-density lipoprotein cholesterol values, we obtained good agreement (weighted kappa: 0.91 and 0.94 for the Afinion AS100 vs. Cholestech LDX and Afinion AS100 vs. laboratory method, respectively) for cardiovascular disease risk calculation using QRISK2. Conclusions Point of care testing can support a 'one stop shop' approach by providing rapid, reliable results. The Afinion AS100 analyser provides a multi-analyte platform and compares well with laboratory-based methods and another well-established point of care testing analyser.

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Section: Discussionmentioning

confidence: 97%

Evaluation of the point of care Afinion AS100 analyser in a community setting

et al. 2016

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“…The presence of microalbuminuria is a marker of vascular damage and endothelial dysfunction, so it is the earliest sign of renal disease in many cases [15,20,21]. Microalbuminuria was found to be a predictor of cardiovascular events and worsening renal function [11][12][13][14]. An association between increased albuminuria even in the normal range and increased risk for cardiovascular events has been determined [15,22].…”

Section: Discussionmentioning

confidence: 99%

“…Microalbuminuria is accepted as an independent risk factor for cardiovascular events and worsening renal function [11][12][13][14]. Also it is a marker of endothelial dysfunction [15].…”

Section: Introductionmentioning

confidence: 99%

Association of neutrophil-to-lymphocyte ratio and microalbuminuria in patients with normal eGFR

Kutlugun

Ebinç

Öztürk

et al. 2018

Romanian Journal of Internal Medicine

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“…The results showed that serum NO levels decreased, and serum ET-1, ICAM-1, VCAM-1, and hsCRP levels significantly increased in the Q 1+2+3 group compared with the Q 4 group that were classified either by MWSS or by PWSS. ACR is not only one of the renal functional markers but is also regarded as one of the most important markers of generalized endothelial dysfunction 24,25 . Endothelial dysfunction leads to impairment of the endothelial barrier, which results in increased transvascular albumin leakage 24,26 .…”

Section: Discussionmentioning

confidence: 99%

Longitudinal association of carotid endothelial shear stress with renal function decline in aging adults with normal renal function: A population-based cohort study

Zhao

Dong

Wang

et al. 2019

Sci Rep

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The aim of this study was to investigate the associations between carotid wall shear stress (WSS) and renal function impairment (RFI) and albuminuria in aging adults. A total of 1,447 subjects aged 60 years and older with normal estimated glomerular filtration rate (eGFR ≥ 60 mL·min−1·1.72 m−2) and albumin/creatinine ratio (ACR < 30 mg·g−1) were enrolled between April 2007 and October 2009 in the Shandong area, China. Carotid WSS was assessed at baseline, and eGFR, which is based on serum creatinine and cystatin C, and ACR were assessed at baseline and at the annual follow-up visits. After an average of 62.9 months of follow-up, the reduction in eGFR and the increase in ACR were significantly higher in the Q1+2+3 group than the Q4 group, as classified by either the interquartile of the mean WSS or the interquartile of the peak WSS after adjustment for multi-variabilities, including the average blood pressures at every annual visit and baseline eGFR and ACR. For groups classified by mean WSS, the hazard ratios (95% confidence intervals) were 3.45 (1.36–8.75, p = 0.008) in the incident RFI and 3.24 3.22 (1.37–7.57, p = 0.009) in the incident albuminuria for the Q1+2+3 group compared with the Q4 group. Similar results were observed among groups classified by peak WSS. The Q1+2+3 group was associated with endothelial dysfunction and inflammation with respect to the Q4 group as classified by mean or peak WSS. The results indicate that carotid WSS plays an important role in RFI and albuminuria progression in aging adults. Lower WSS was associated with a higher risk of RFI and albuminuria compared with higher WSS.

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Physical activity is inversely associated with microalbuminuria in hypertensive patients at high cardiovascular risk: data from I-SEARCH

Abstract: In hypertensive patients at high cardiovascular risk, physical activity is an independent predictor for a decreased risk of microalbuminuria.

Cited by 8 publications

References 46 publications

Evaluation of the point of care Afinion AS100 analyser in a community setting

Evaluation of the point of care Afinion AS100 analyser in a community setting

Association of neutrophil-to-lymphocyte ratio and microalbuminuria in patients with normal eGFR

Longitudinal association of carotid endothelial shear stress with renal function decline in aging adults with normal renal function: A population-based cohort study

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