Physical activity modulates effects of some genetic polymorphisms affecting cardiovascular risk in men aged over 40 years

Pisciotta, Livia; Cantafora, A.; Piana, A; Masturzo, P; Cerone, R.; Minniti, G.; Bellocchio, Antonella; Reggiani, Enrico; Armani, U; Bertolini, Stefano

doi:10.1016/s0939-4753(03)80012-1

Cited by 19 publications

(19 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a cross-sectional study, ε4 carriers showed a significant protective effect of high-intensity activity, with athletic ε2, ε3, and ε4 carriers having similar blood lipid profiles and sedentary ε4 carriers showing significantly high levels of lipid risk factors for CAD [69]. A similar result was found in a cross-sectional study of middle-aged highly fit and age-matched sedentary groups, where inactive ε4 carriers had elevated risk factors of CAD, including higher circulating LDL levels compared with physically active ε4 carriers, and compared with ε3 carriers regardless of aerobic activity levels [70]. Thus, physical activity seems to diminish CAD risks in APOE ε4 carriers to ε4 noncarrier levels, whereas sedentary lifestyles may exacerbate CAD risk factors among ε4 carriers.…”

Section: Interaction Between Physical Activity and Apoe Genotypesupporting

confidence: 57%

Exercise, APOE genotype, and the evolution of the human lifespan

Raichlen

Alexander

2014

Trends in Neurosciences

107

View full text Add to dashboard Cite

Humans have exceptionally long lifespans compared with other mammals. However, our longevity evolved when our ancestors had two copies of the apolipoprotein E (APOE) ε4 allele, a genotype that leads to a high risk of Alzheimer’s disease (AD), cardiovascular disease, and increased mortality. How did human aging evolve within this genetic constraint? Drawing from neuroscience, anthropology, and brain-imaging research, we propose the hypothesis that the evolution of increased physical activity approximately 2 million years ago served to reduce the amyloid plaque and vascular burden of APOE ε4, relaxing genetic constraints on aging. This multidisciplinary approach links human evolution with health and provides a complementary perspective on aging and neurodegenerative disease that may help identify key mechanisms and targets for intervention.

show abstract

Section: Interaction Between Physical Activity and Apoe Genotypesupporting

confidence: 57%

Exercise, APOE genotype, and the evolution of the human lifespan

Raichlen

Alexander

2014

Trends in Neurosciences

107

View full text Add to dashboard Cite

show abstract

“…Considering the level of aerobic fitness, the probability of elevated LDL cholesterol was only higher among adolescents with adequate aerobic fitness carrying ε4 allele (15% to 48%) when compared to the other groups, and among those carrying ε3 allele (30%) when compared to those carrying ε2 allele (Table 3). These findings seems to indicate that in adolescents the protective effect of ε2 in relation to ε4 depends on adequate aerobic fitness, in agreement with the study of Pisciotta et al (2003).…”

Section: Discussionsupporting

confidence: 91%

“…In contrast, in inactive individuals higher concentrations of this lipoprotein were found among those carrying ε2 allele (Corella et al, 2001). In addition, inactive individuals, but not physically active individuals, carrying ε4 allele were found to have higher LDL concentrations than carriers of the other alleles (Pisciotta et al, 2003).…”

Section: Introductionmentioning

confidence: 84%

Aerobic fitness modulates the association between APOE genotypes and serum lipemia in adolescents

Glaner¹,

Nascimento²,

Nóbrega³

2014

Motriz: rev. educ. fis.

View full text Add to dashboard Cite

Abstract-The purpose of this study was to analyze the association between APOE alleles and serum lipemia in adolescents with low and adequate aerobic fitness. The sample was comprised of 105 boys and 151 girls (49% and 46% from rural area) of European ancestry, aged 11 to 17 years, and classified according to: 1) APOE genotype: group ε2 (ε2/3+ε2/2), ε3 (ε3/3), and ε4 (ε3/4+ε4/4); 2) aerobic fitness: adequate or low; 3) serum lipemia: elevated total cholesterol (TC), low-density lipoprotein (LDL) and triglycerides, and low high-density lipoprotein (HDL). The results showed that aerobic fitness modulates the association between APOE alleles and serum lipemia in adolescents, suggesting that adequate aerobic fitness levels exert a greater effect of reducing TC and LDL in ε2 carriers, as well as of increasing HDL and reducing triglycerides in ε3 and ε4 carriers. Keywords: apolipoproteins E, physical endurance, adolescent health, lipoproteinsResumo-"Aptidão física aeróbica modula a associação entre genótipos da APOE e lipemia sérica em adolescentes." O objetivo deste estudo foi analisar a associação entre os alelos da APOE e a lipemia sérica em adolescentes com baixa e adequada aptidão aeróbia. Amostra: 105 rapazes(49% da área rural) e 151 moças (46% da área rural) descendentes de europeus, com idade de 11 a 17 anos, classificados de acordo com 1) genótipo da APOE: grupo ε2 (ε2/3+ε2/2), ε3 (ε3/3), e ε4 (ε3/4+ε4/4); 2) aptidão aeróbia: adequada ou baixa; 3) lipemia sérica: elevados colesterol total (CT), lipoproteína de baixa densidade (LDL) e triglicérides, e baixa lipoproteína de alta densidade (HDL). Os resultados demonstram que a aptidão aeróbia modula a associação dos alelos da APOE com a lipemia sérica de adolescentes, sugerindo que níveis adequados de aptidão aeróbia têm efeito maior em reduzir CT e LDL elevados nos portadores do alelo ε2, bem como o efeito maior em aumentar HDL e reduzir triglicerídeos naqueles com ε3 e ε4. Palavras-chave: apolipoproteína E, resistência física, saúde do adolescente, lipoproteínasResumen-"La condición física aeróbica modula la asociación entre los genotipos APOE y lipemia sérico en adolescentes." El objetivo fue analizar la asociación entre los alelos APOE y la lipemia sérica en adolescentes con baja y adecuada condición aeróbica. La muestra fue composta de 105 niños (49% de las zonas rurales) y 151 niñas (46% de las zonas rurales) de origen europeo, con edades entre 11-17 años, clasificados de acuerdo con 1) el genotipo APOE: grupo ε2 (ε2 / 3 + ε2 / 2), ε3 (ε3 / 3), y ε4 (ε3 / ε4 + 4/4); 2) la condición aeróbica: adecuada o baja; 3) suero lipémico: colesterol (CT), lipoproteínas de baja densidad (LDL) y los triglicéridos elevados y lipoproteínas de alta densidad (HDL) bajo. Los resultados muestran que la capacidad aeróbica modula la asociación de los alelos APOE con la lipemia de los adolescentes, lo que sugiere que niveles adecuados de capacidad aeróbica tienen mayor efecto en la reducción de CT y LDL elevados en el alelo ε2, y el mayor efecto para aumentar el HDL y la reducci...

show abstract

“…Sentí et al (54) reported that the HϩHϩ genotype of the lipoprotein lipase (LPL) HindIII polymorphism was only associated with increased serum TG levels in physically inactive men who had a smoking habit. Moreover, it was reported that the TG-raising effect of the ApoA-II-265TT genotype was blunted in high-fitness men (49). However, these studies focused on only a single gene, and the effects of physical activity or CRF on the polygenic effects of blood TG levels have never been examined.…”

Section: Discussionmentioning

confidence: 99%

“…A number of SNPs have been shown to attenuate the beneficial effects of exercise on blood lipid profile (22,59). Conversely, several studies showed that a high level of physical activity attenuated the genetic risk for dyslipidemia (49,54). However, these previous studies only focused on a single SNP.…”

mentioning

confidence: 99%

Polygenic risk for hypertriglyceridemia is attenuated in Japanese men with high fitness levels

Tanisawa

Ito

Sun

et al. 2014

Physiological Genomics

View full text Add to dashboard Cite

High cardiorespiratory fitness (CRF) is associated with a reduced risk for dyslipidemia; however, blood lipid levels are also affected by individual genetic variations. We performed a cross-sectional study to determine whether CRF modifies polygenic risk for dyslipidemia. Serum levels of triglycerides (TG), LDL cholesterol (LDL-C), and HDL cholesterol (HDL-C) were measured in 170 Japanese men (age 20-79 yr). CRF was assessed by measuring maximal oxygen uptake (Vo2max), and subjects were divided into low-fitness and high-fitness groups according to the reference Vo2max value for health promotion in Japan. We analyzed 19 single nucleotide polymorphisms (SNPs) associated with TG, LDL-C, or HDL-C levels. Based on these SNPs, we calculated three genetic risk scores (GRSs: TG-GRS, LDL-GRS, and HDL-GRS), and subjects were divided into low, middle, and high groups according to the tertile for each GRS. Serum TG levels of low-fitness individuals were higher in the high and middle TG-GRS groups than in the low TG-GRS group (P < 0.01 and P < 0.05, respectively), whereas no differences were detected in the TG levels of high-fitness individuals among the TG-GRS groups. In contrast, the high LDL-GRS group had higher LDL-C levels than did the low LDL-GRS group, and HDL-C levels were lower in the high HDL-GRS group than in the low HDL-GRS group regardless of the fitness level (P < 0.05). These results suggest that high CRF attenuates polygenic risk for hypertriglyceridemia; however, high CRF may not modify the polygenic risk associated with high LDL-C and low HDL-C levels in Japanese men.

show abstract

Physical activity modulates effects of some genetic polymorphisms affecting cardiovascular risk in men aged over 40 years

Cited by 19 publications

References 42 publications

Exercise, APOE genotype, and the evolution of the human lifespan

Exercise, APOE genotype, and the evolution of the human lifespan

Aerobic fitness modulates the association between APOE genotypes and serum lipemia in adolescents

Polygenic risk for hypertriglyceridemia is attenuated in Japanese men with high fitness levels

Contact Info

Product

Resources

About