Physical activity, physical fitness and the effect of exercise training interventions in lymphoma patients: a systematic review

Wolter, Pascal; Verhoef, Gregor; Gosselink, Rik

doi:10.1007/s00277-013-1689-1

Cited by 31 publications

(31 citation statements)

References 98 publications

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“…75 Exercise resulted in a decrease in fatigue from baseline to 12 weeks’ follow-up (standardized mean difference [SMD], −0.38; 95% CI, −0.57 to −0.18) or when comparing differences in follow-up scores at 12 weeks (SMD, −0.73; 95% CI, −1.14 to −0.31). Systematic reviews have correlated exercise with improvement in fatigue for patients with prostate cancer 76 and lymphoma, 77 and in those who have undergone hematopoietic cell transplant. 78 Other smaller analyses confirmed a significant effect of exercise intervention on fatigue.…”

Section: Interventions For Patients On Active Treatmentmentioning

confidence: 99%

Cancer-Related Fatigue, Version 2.2015

Berger¹,

Mooney²,

Alvarez-Perez³

et al. 2015

J Natl Compr Canc Netw

679

511

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Cancer-related fatigue is defined as a distressing, persistent, subjective sense of physical, emotional, and/or cognitive tiredness or exhaustion related to cancer or cancer treatment that is not proportional to recent activity and interferes with usual functioning. It is one of the most common side effects in patients with cancer. Fatigue has been shown to be a consequence of active treatment, but it may also persist into posttreatment periods. Furthermore, difficulties in end-of-life care can be compounded by fatigue. The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Cancer-Related Fatigue provide guidance on screening for fatigue and recommendations for interventions based on the stage of treatment. Interventions may include education and counseling, general strategies for the management of fatigue, and specific nonpharmacologic and pharmacologic interventions. Fatigue is a frequently underreported complication in patients with cancer and, when reported, is responsible for reduced quality of life. Therefore, routine screening to identify fatigue is an important component in improving the quality of life for patients living with cancer.

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Section: Interventions For Patients On Active Treatmentmentioning

confidence: 99%

Cancer-Related Fatigue, Version 2.2015

Berger¹,

Mooney²,

Alvarez-Perez³

et al. 2015

J Natl Compr Canc Netw

679

511

View full text Add to dashboard Cite

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“…Limited data, from randomized controlled trials and observational studies, indicate that higher levels of physical activity after a diagnosis of NHL may lead to a range of clinically relevant physical and psychological outcomes, such as increased aerobic capacity and muscular strength, lower body mass, decreased fatigue, and increased quality of life . Sedentary behavior (activities performed in a seated or reclining posture, with low energy expenditure ) has also been associated with a range of physical and psychosocial outcomes including obesity, lower quality of life, and increased fatigue , although these have generally been cross‐sectional studies and none have been conducted among NHL survivors.…”

Section: Introductionmentioning

confidence: 99%

“…Sedentary behavior (activities performed in a seated or reclining posture, with low energy expenditure ) has also been associated with a range of physical and psychosocial outcomes including obesity, lower quality of life, and increased fatigue , although these have generally been cross‐sectional studies and none have been conducted among NHL survivors. It therefore appears possible that increasing physical activity and decreasing sedentary time may positively influence physical and psychosocial outcomes in NHL survivors, particularly fatigue, which is a commonly reported problem among lymphoma patients . As such, it is important to describe in detail the physical activity and sedentary behavior of NHL survivors.…”

Section: Introductionmentioning

confidence: 99%

Volume and correlates of objectively measured physical activity and sedentary time in non‐Hodgkin lymphoma survivors

et al. 2015

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“…another explanation for the high Pa levels may be the active lifestyle of effect is the stability over time of both Pa and fatigue. a recent review study indicated that 21-29% of the lymphoma patients met the american College of Sports Medicine Pa guidelines [7], this was approximately 87-90% in our study. although most of the participants in our study were sufficiently active, there still remains room for improvement for these patients, as our analyses also showed that fatigue improved with each additional hour of Pa. it could also be that exercise (specifically planned, structured, and repetitive training) has larger beneficial effects on fatigue than Pa (activities that get the body moving such as gardening) alone.…”

Section: Discussionmentioning

confidence: 67%

“…a cross-sectional study showed that lower levels of physical activity (Pa) were associated with more symptoms of fatigue among lymphoma patients [6]. a recent systematic review showed that aerobic exercise training interventions seem to be feasible and safe and have positive effects on fatigue levels of lymphoma patients [7]. Longitudinal studies among patients are needed to evaluate whether Pa has a sustained effect on fatigue.…”

mentioning

confidence: 99%

High levels of physical activity are associated with lower levels of fatigue among lymphoma patients: Results from the longitudinal PROFILES registry

Husson¹,

Oerlemans²,

Mols³

et al. 2015

Acta Oncologica

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Background. Studies show a cross-sectional association between physical activity (PA) and fatigue among lymphoma cancer patients. However, few longitudinal studies have examined whether PA has a sustained effect on fatigue over time. Purpose. To examine the longitudinal relationship between PA and fatigue. Methods. All living individuals diagnosed with lymphoma between 1999 and 2010 as registered by the Dutch population-based Eindhoven Cancer Registry received a questionnaire on three time points. Generalized linear mixed models were used to estimate the independent effects of PA on fatigue. Results. PA and fatigue levels did not differ between patients short-term ( Ͻ 1 year) and long-term after diagnosis (1 -5 years or Ͼ 5 years). PA behavior was relatively constant over time with 84% of the patients meeting the Dutch PA guidelines at all assessment periods. Fatigue scores also remained fairly stable over time with 46% of the patients never being fatigued and 29% always being fatigued. Multivariate analyses showed that patients who met the PA guidelines scored 6.2 (95% CI 3.1 -9.2) points lower on total fatigue over time (between subject effect; p Ͻ 0.01), compared to patients not meeting PA guidelines. Conclusion. During a period of two years, PA and fatigue levels were rather stable within lymphoma patients. Patients who met the PA guidelines reported lower levels of fatigue compared to those not meeting the guidelines, which appeared to be a constant association over time. The observed association between PA and fatigue underlines the importance to focus upon physical training in the care of cancer patients.

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Physical activity, physical fitness and the effect of exercise training interventions in lymphoma patients: a systematic review

Cited by 31 publications

References 98 publications

Cancer-Related Fatigue, Version 2.2015

Cancer-Related Fatigue, Version 2.2015

Volume and correlates of objectively measured physical activity and sedentary time in non‐Hodgkin lymphoma survivors

High levels of physical activity are associated with lower levels of fatigue among lymphoma patients: Results from the longitudinal PROFILES registry

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