I n 1948, the World Health Organization defined health not as the absence of illness but as the presence of physical, mental, and social well-being. 1 However, it was not until the 1980's that the primary focus of research and policy efforts related to aging shifted from disease and decline to health and growth. The term successful aging was made popular in the late 1980s with the seminal work from the MacArthur study, in which successful aging was defined as involving 3 main factors (1) being free of disability or disease, (2) having high cognitive and physical abilities, and (3) interacting with others in meaningful ways. 2 Since then, numerous definitions and models of successful aging have been introduced with some estimating only 1% of the population achieve successful aging, whereas others estimate closer to 90% of people experience it. 3,4 When asked, older individuals typically describe successful aging as being productive, mentally sharp, and able to do what is important to them for as long as they can.Given the substantial increase in the 65-and-older population, which grew by over one-third since 2010, it is important to under-stand how we can help the aging population continue to live a meaningful life. Maintaining cognitive function is an important component to determining successful aging. Brain health has a significant impact on activities of daily living and the ability to live independently, as well as contributes to our physical health. 5 In light of its critical role, we have seen an increased attention to brain health from medical and scientific communities, as well as businesses over the last decade. The global neuroscience market was estimated at US$42.5 billion in 2022 and is expected to grow at a compound annual growth rate of 5.56% from 2023 to 2030. 6 In 2013, the U.S. announced the launch of the Brain Project, which aims to accelerate the development and application of new technologies to reveal the dynamic changes of the brain structure and function with aging. Shortly after, US$177 million was donated to establish the Global Brain Health Institute, which is the largest program grant ever made by the Atlantic Philanthropies. The Global Brain Health Institute is dedicated to protecting the world's aging populations from threats to brain health through training, research, dissemination of knowledge, and advocacy. 7 Research has increased our understanding of prevention and intervention mechanisms to promote a healthy brain. Today we know that the aging brain retains a considerable functional plasticity, and that this plasticity is positively promoted by genes activated by different lifestyle factors. 8 Research suggests that lifestyle behavior carries more influence on brain health than genetics. In fact, several of the key modifiable risk factors linked to cardiovascular disease are also closely associated with brain health. The American Heart Association (AHA)/American Stroke Association Presidential Advisory identified 7 metrics to define optimal brain health in adults that ori...