Urine bioassay ~easurements for uranium and medical laborato ry resu~ts were studied to determine whether there were any health effects from urcnium intake among a group of 31 workers exposed to uranium hexafluoride (UF6) and hydrolysis products following the accidental rupture of a 14-tun shipping cylinder in early 1986 at the Sequoyah FJels Corporation uranium conversion facility in Gore, Oklahoffid. Physiological indicators studied to detect kidney tissue damage inc "i uded tests for urinary protein, casts and cells, blood, specific gravity, and urine pH, blood urea nitrogen, and blood creatinine. We concluded after reviewing two years of follow-up medical data that none of the 31 workers sustained any observable health effects from exposure to uranium. The early excretion of uranium in urine showed more rapid systemic uptake of uranium from the lung than is assumed using the International Commission on Radiological Protection (ICRP) Publication 30 and Publication 54 models. The urinary excretion dota from these workers were USE" to develop an improved systemic recycling model for inhaled soluble uranium. We estimated initial intakes, clearance rates, kidney burdens, and resulting radiation doses to lungs, kidneys, and bone surfaces. Radiation dose limits and limits on intake, as recommended by the JCRP , were not exceeded. However, the NRC derived limit of 9.6 mg was exceeded by eight of the 31 workers. Maximum kidney concentrations in exposed workers ranged from 0.05 to 2.5 ~~ U/g kidney tissue. We found no toxicological effects on the kidneys of workers at these concentrations. Uranium urinalyses and medical laboratol'Y result s on Dlo od dnli lit' in c were studied to determine whether ~here were Jnv health eff ect s i n 3 1 \':orkcl's exposed to uranium hexafluoride (UF6) following-the acciden ta l r u~lu r e of d 14-ton shipping cylinde:r in early 1986 at a uranium convers io n facil ity in Gore, Oklahoma. The workers were likely exposed t o very hi gtl concent ' ,t(ia/;s of ai rborne uranium for short time periods. The mos t imp ort Jnt Sil()\'t •, t eli ll concern was inhalation of hydrofluoric acid (HF) with pos s ibl e l ung d lilldge and skin-exposure burns. The major long-term concern wa s kidney dd ll ldCJC in workers with significant intakes of uranium. Urinalyse s wet' e pe r forJ1!ed 0 11 workers to evaluate their health and kidney function. The data were also evaluated to estimate their initial intakes of ura~ium, resulting r adi ation doses to bone surfcces, kidneys, and lungs, and the resu It i ng (oIllmi tte d effective dose equivalent (a measure of risk to the whole body). ~he physiological indicators studied to detect kidney tissue damage by uranium poisoning included tests for urinary protein, casts and cells, urinary blood, specific gravity, pH of the urine, blood urea nitrogen, and blood creatinine. Physical examination and pulmonary function ' est res ults over a two-year follow-up period were also evaluated. We conclud ed fr om review of the medical records and laboratory results tha...