Physical and chemical stability of drug nanoparticles

Wu, Libo; Zhang, Jian; Watanabe, Wiwik

doi:10.1016/j.addr.2011.02.001

Cited by 819 publications

(473 citation statements)

References 120 publications

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“…It is essential to note however, that prior to any toxicity testing, the NP must be thoroughly characterized with respect to their purity (chemical and biological contaminants) and physicochemical properties both in a dry and wet state 42,74 . More detailed information on characterisation of NP will not be provided here as this falls beyond the scope of the current review but can be found in overviews elsewhere 42,[75][76][77] . In this section the main methodological principles for in in vitro and in vivo nanotoxicity evaluation will be reviewed as well as the most important shortcomings of these methods.…”

Section: Routine Methods For Nanotoxicity Testingmentioning

confidence: 99%

Assessing nanoparticle toxicity in cell-based assays: influence of cell culture parameters and optimized models for bridging the in vitro–in vivo gap

et al. 2013

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Section: Routine Methods For Nanotoxicity Testingmentioning

confidence: 99%

Assessing nanoparticle toxicity in cell-based assays: influence of cell culture parameters and optimized models for bridging the in vitro–in vivo gap

et al. 2013

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“…In recent years, encapsulation of antimicrobial drugs in nanoparticle systems has emerged as an innovative and promising alternative that enhances therapeutic eff ectiveness and minimizes undesirable side eff ects of drugs (14). Extensive studies have demonstrated that nanoparticles such as liposomes, polymeric nanoparticles, solid lipid nanoparticles and others can be used for antimicrobial drug delivery and controlled release (15). Encapsulation provides a means to control stability, solubility, and bioavailability, as well as release of bioactive components.…”

Section: Effect Of Encapsulation On Antimicrobial Activity Of Herbal mentioning

confidence: 99%

“…They have been extensively studied in pharmaceutical and cosmetic industries (15)(16)(17). Their bilayer structure, resembling cell membrane, enables their easy fusing with infectious microorganisms.…”

Section: Effect Of Encapsulation On Antimicrobial Activity Of Herbal mentioning

confidence: 99%

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Effect of Encapsulation on Antimicrobial Activity of Herbal Extracts with Lysozyme

Matoušková

Márová

Bokrová

et al. 2016

Food Technol. Biotechnol.

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SummaryResistance of microorganisms to antibiotics has increased. The use of natural components with antimicrobial properties can be of great signifi cance to reduce this problem. The presented work is focused on the study of the eff ect of encapsulation of selected plant and animal antimicrobial substances (herbs, spices, lysozyme and nisin) on their activity and stability. Antimicrobial components were packaged into liposomes and polysaccharide particles (alginate, chitosan and starch). Antimicrobial activity was tested against two Gram-positive (Bacillus subtilis and Micrococcus luteus) and two Gram-negative (Escherichia coli and Serratia marcescens) bacteria. Encapsulation was successful in all types of polysaccharide particles and liposomes. The prepared particles exhibited very good long-term stability, especially in aqueous conditions. Antimicrobial activity was retained in all types of particles. Liposomes with encapsulated herb and spice extracts exhibited very good inhibitory eff ect against all tested bacterial strains. Most of herbal extracts had very good antimicrobial eff ect against the tested Gram-negative bacterial strains, while Gram-positive bacteria were more sensitive to lysozyme particles. Thus, particles with co-encapsulated herbs and lysozyme are more active against diff erent types of bacteria, and more stable and more eff ective during long-term storage. Particles with encapsulated mixture of selected plant extracts and lysozyme could be used as complex antimicrobial preparation with controlled release in the production of food and food supplements, pharmaceutical and cosmetic industries.

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“…The natural tendency for aggregation upon storage is actually one of the important limitations of nanoparticle application (Sameti et al, 2003;Wu et al, 2011). This tendency is attributed to the fact that, when two particles come into contact, the attractive potential is much greater than the kinetic energy that could induce their separation (Ikeda and Zhong, 2012).…”

Section: Nanoparticle Stability In Storage and Upon Freeze-dryingmentioning

confidence: 99%

Pullulan-based nanoparticles as carriers for transmucosal protein delivery

Dionísio

Cordeiro

Remuñán‐López

et al. 2013

European Journal of Pharmaceutical Sciences

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Polymeric nanoparticles have revealed very effective in transmucosal delivery of proteins. Polysaccharides are among the most used materials for the production of these carriers, owing to their structural flexibility and propensity to evidence biocompatibility and biodegradability. In parallel, there is a preference for the use of mild methods for their production, in order to prevent protein degradation, ensure lower costs and easier procedures that enable scaling up.In this work we propose the production of pullulan-based nanoparticles by a mild method of polyelectrolyte complexation. As pullulan is a neutral polysaccharide, sulfated and aminated derivatives of the polymer were synthesized to provide pullulan with a charge. These derivatives were then complexed with chitosan and carrageenan, respectively, to produce the nanocarriers. Positively charged nanoparticles of 180-270 nm were obtained, evidencing ability to associate bovine serum albumin, which was selected as model protein. In PBS pH 7.4, pullulan-based nanoparticles were found to have a burst release of 30% of the protein, which maintained up to 24h. Nanoparticle size and zeta potential were preserved upon freeze-drying in the presence of appropriate cryoprotectants. A factorial design was approached to assess the cytotoxicity of raw materials and nanoparticles by the metabolic test MTT. Nanoparticles demonstrated to not cause overt toxicity in a respiratory cell model (Calu-3). Pullulan has, thus, demonstrated to hold potential for the production of nanoparticles with an application in protein delivery.

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Physical and chemical stability of drug nanoparticles

Cited by 819 publications

References 120 publications

Assessing nanoparticle toxicity in cell-based assays: influence of cell culture parameters and optimized models for bridging the in vitro–in vivo gap

Assessing nanoparticle toxicity in cell-based assays: influence of cell culture parameters and optimized models for bridging the in vitro–in vivo gap

Effect of Encapsulation on Antimicrobial Activity of Herbal Extracts with Lysozyme

Pullulan-based nanoparticles as carriers for transmucosal protein delivery

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