Physical and chemical studies related to the development of m‐THPC (FOSCAN®) for the photodynamic therapy (PDT) of tumours

Bonnett, Raymond; Djelal, Birgul D.; Nguyen, Angelina

doi:10.1002/jpp.377.abs

Cited by 26 publications

(33 citation statements)

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“…9. EPR spectra acquired in the solid state at room temperature for (i) Gd(NO3)3 salt, (ii) Gd2O3 NPs (1) and (iii) Si-Gd2O3 NPs (2). Inset: zoomed in section to show the spectra obtained for the NPs.…”

Section: Electron Paramagnetic Resonancementioning

confidence: 99%

“…Phthalocyanines, particularly metallophthalocyanines, attract a great deal of attention in a wide variety of applications including photodynamic therapy of cancer [2], non-linear optics [3], as well as photosensitized catalytic applications [4][5][6][7]. Properties such as their high extinction coefficients, remarkable absorption of visible light and photoactivity, high chemical and thermal stability, and their ability to generate singlet oxygen makes these phthalocyanines ideally suited to applications such as photocatalysis [4].…”

Section: Introductionmentioning

confidence: 99%

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Surface modification of silica-coated gadolinium oxide nanoparticles with zinc tetracarboxyphenoxy phthalocyanine for the photodegradation of Orange G

Ledwaba

Masilela

Nyokong

et al. 2015

Journal of Molecular Catalysis A: Chemical

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Section: Electron Paramagnetic Resonancementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Surface modification of silica-coated gadolinium oxide nanoparticles with zinc tetracarboxyphenoxy phthalocyanine for the photodegradation of Orange G

Ledwaba

Masilela

Nyokong

et al. 2015

Journal of Molecular Catalysis A: Chemical

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“…Foslip is a more recently developed third generation photosensitizer based on a DPPC/DPPG liposomal formulation of 5,10,15,20-tetrakis(m-hydroxyphenyl)chlorin [128]. Like for Visudyne  many studies have been published on Foslip.…”

Section: Liposomes As Photosensitizer Carriersmentioning

confidence: 99%

Nanodrug applications in photodynamic therapy

Paszko

Ehrhardt

Senge

et al. 2011

Photodiagnosis and Photodynamic Therapy

326

215

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SummaryPhotodynamic therapy (PDT) has developed over last century and is now becoming a more widely used medical tool having gained regulatory approval for the treatment of various diseases such as cancer and macular degeneration. It is a two-step technique in which delivery of a photosensitizing drug is followed by irradiation of light. Activated photosensitizers transfer energy to molecular oxygen which results in generation of reactive oxygen species which in turn cause cells apoptosis or necrosis. Although this modality has significantly improved quality of life and survival time for many cancer patients it still offers significant potential for further improvement. In addition to the development of new PDT drugs, the use of nanosized carriers for photosensitizers is a promising approach which might improve the efficiency of photodynamic activity and which can overcome many side effects associated with classic photodynamic therapy. This review aims at highlighting the different types of nanomedical approaches currently used in PDT and outlines future trends and limitations of nanodelivery of photosensitizers. PDT -photodynamic therapy; PGA -poly(glycolic acid); PGLA -poly(D,L-lactide-coglycolide); PLA -poly(lactic acid); PS -photosensitizer; PEG -polyethylene glycol; ALA  aminolevulinic acid; m-THPC  5,10,15,20-tetra-(m-hydroxyphenyl)chlorine; m-THPP  meso-tetra(p-hydroxyphenyl); PpIX  protoporphyrin; Hp  hematoporphyrin; Pc4  silicon phthalocyanine; Ig  immunoglobulin; Tf  transferrin; TfR  transferrin receptor; VEGF  vascular endothelial growth factor; EPR  enhanced permeability and retention effect; FRET  fluorescence resonance energy transfer; MRI  magnetic resonance imaging; RES  reticuloendothelial system; ROS  reactive oxygen species; NP  nanoparticle; ND -nanodiamonds; SNP  silica nanoparticle; AMD  age-related macular degeneration; CNV  choroidal neovascularization; PTT  photothermal therapy;

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“…In addition, the temoporfin molecule is hydrophobic, leading to its poor water solubility and aggregation within the vasculature. This fact could cause a variety of disadvantages, such as limited selective uptake by the tumor, decreases in its biodistribution, and changes in the spectroscopic and photosensitizing characteristics of the compound [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetic and biodistribution study following systemic administration of Fospeg® – a Pegylated liposomal mTHPC formulation in a murine model

Xie

Svenmarker

Axelsson

et al. 2013

Journal of Biophotonics

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Fospeg® is a newly developed photosensitizer formulation based on meso-tetra(hydroxyphenyl)chlorin (mTHPC), with hydrophilic liposomes to carry the hydrophobic photosensitizer to the target tissue. In this study the pharmacokinetics and biodistribution of Fospeg® were investigated by high performance liquid chromatography at various times (0.5-18 hours) following systemic i.v. administration. As a model an experimental HT29 colon tumor in NMRI nu/nu mice was employed. Our study indicates a higher plasma peak concentration, a longer circulation time and a better tumor-to-skin ratio than those of Foslip®, another liposomal mTHPC formulation. Data from ex vivo tissue fluorescence and reflectance imaging exhibit good correlation with chemical extraction. Our results have shown that optical imaging provides the potential for fluorophore quantification in biological tissues.

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Physical and chemical studies related to the development of m‐THPC (FOSCAN®) for the photodynamic therapy (PDT) of tumours

Cited by 26 publications

References 0 publications

Surface modification of silica-coated gadolinium oxide nanoparticles with zinc tetracarboxyphenoxy phthalocyanine for the photodegradation of Orange G

Surface modification of silica-coated gadolinium oxide nanoparticles with zinc tetracarboxyphenoxy phthalocyanine for the photodegradation of Orange G

Nanodrug applications in photodynamic therapy

Pharmacokinetic and biodistribution study following systemic administration of Fospeg® – a Pegylated liposomal mTHPC formulation in a murine model

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