Physical and cognitive training are able to prevent recognition memory deficits related to amyloid beta neurotoxicity

Daré, Letícia Rossi; Garcia, Alexandre; Alves, Niége; Dias, Daniel Ventura; Souza, Mauren Assis; Mello‐Carpes, Pâmela Billig

doi:10.1016/j.bbr.2019.03.007

Cited by 20 publications

(13 citation statements)

References 41 publications

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“…Despite these positive observations, the mechanisms by which CE acts in the AD brain are not yet well described. Recently, using an animal model of Aβ neurotoxicity, we showed that CE is effective in protecting against memory deficits when it is performed before neurotoxicity induction (Rossi Dare et al, 2019). In this case, we observed that CE was able to avoid the brain oxidative imbalance induced by Aβ.…”

Section: Introductionmentioning

confidence: 65%

“…Individuals who practice regular physical activity have a 30-40% reduced risk of AD development in comparison to physically inactive individuals (Aarsland et al, 2010;Williams et al, 2010). Several studies have demonstrated that aerobic PE, such as running or swimming exercise, improved memory in rats with Aβ-induced AD (Kim et al, 2014;Özbeyli et al, 2017;Prado Lima et al, 2018;Rossi Dare et al, 2019). Exercise-induced factors, including neurogenesis, synaptic plasticity, and increased cerebral blood flow, seem to promote beneficial effects on the brain (Tari et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

“…It is important to highlight that our group has already demonstrated that CE is as good as PE as a preventive strategy for memory deficits related to Aβ neurotoxicity (Rossi Dare et al, 2019). Despite the well-demonstrated preventive effects of PE and CE, we investigated whether the same strategies could be used to treat memory deficits.…”

Section: Introductionmentioning

confidence: 99%

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The Reversal of Memory Deficits in an Alzheimer’s Disease Model Using Physical and Cognitive Exercise

Daré

Garcia

Soares

et al. 2020

Front. Behav. Neurosci.

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Alzheimer's disease (AD) is the leading cause of dementia in the world, accounting for 50-75% of cases. Currently, there is limited treatment for AD. The current pharmacological therapy minimizes symptom progression but does not reverse brain damage. Studies focused on nonpharmacological treatment for AD have been developed to act on brain plasticity and minimize the neurotoxicity caused by the amyloid-beta (Aβ) peptide. Using a neurotoxicity model induced by Aβ in rats, the present study shows that physical (PE) and cognitive exercise (CE) reverse recognition memory deficits (with a prominent effect of long-term object recognition memory), decrease hippocampal lipid peroxidation, restore the acetylcholinesterase activity altered by Aβ neurotoxicity, and seems to reverse, at least partially, hippocampal tissue disorganization.

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Section: Introductionmentioning

confidence: 65%

Section: Discussionmentioning

confidence: 99%

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The Reversal of Memory Deficits in an Alzheimer’s Disease Model Using Physical and Cognitive Exercise

Daré

Garcia

Soares

et al. 2020

Front. Behav. Neurosci.

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“…With that, the main mediators of neuroinflammation such as interleukin-6 (IL-6) and soluble trigger receptor expressed from myeloid cells 2 (sTREM2) were modulated in AD patients after 16 weeks of PA (Jensen et al, 2019a). Third, PA provided protection of cognitive functions against Aβ-induced memory deficits associated with the formation of oxidative stress and hippocampal cellular disorganization (Rossi Dare et al, 2019). Fourth, PA consisting of aerobic and resistance exercises decreases acetylcholinesterase (AChE), thus improving cognition and memory functions of patients with AD (Farzi et al, 2019).…”

Section: Physical Activitymentioning

confidence: 98%

Nonpharmacological treatment options for Alzheimer’s disease: from animal testing to clinical studies

Türkez¹,

Arslan²,

Stefano³

et al. 2020

Turk J Zool

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Despite extensive pharmacological approaches, there is no curative therapy for Alzheimer's disease (AD) or other types of dementias. While current pharmacological options alleviate some symptoms of AD, they can lead to various adverse effects. Hence, nonpharmacological treatment options for AD are often considered with the assumption that they are safe, effective, and economic in managing patients. Furthermore, studies on animal models have suggested that environmental exposures like diet, music, or rewardrelated actions can stimulate neuronal regeneration and differentiation without using any pharmacological factors. The aim of this review is to provide a summary of nonpharmacological treatment options for the management of cognitive, emotional, and behavioral symptoms of AD. In addition, this review provides an overview of the challenging and encouraging experiences and recent studies and problems in cognitive training related to animal models. Nonpharmacological studies of AD are discussed in this literature review in terms of animal models, physical activity, brain stimulation, and the role of social communication.

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“…Second, due to the heterogeneous etiologies of SCD [17], the effects of current drugs targeting AD may be uncertain. Third, previous studies have reported the close relationship between several vascular and lifestylerelated risk factors and increased risk of dementia [18][19][20][21]. Approximately one-third of AD patients worldwide may be attributable to nine modifiable risk factors, such as low education, midlife obesity, midlife hypertension, diabetes, smoking, less of exercises, low social contact, hearing ability declined, and depression, which provide us a potential prevention strategy for individuals at risk for AD [20].…”

Section: Introductionmentioning

confidence: 98%

Advances in Non-Pharmacological Interventions for Subjective Cognitive Decline: A Systematic Review and Meta-Analysis

Sheng

Yang

Wang

et al. 2020

JAD

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Background: Subjective cognitive decline (SCD) is considered the earliest symptomatic manifestation of preclinical Alzheimer’s disease (AD). Currently, given the lack of effective and curable pharmacological treatments for AD, non-pharmacological interventions (NPIs) for individuals with SCD may provide a valuable opportunity for the secondary prevention of AD. Objective: This systematic review and meta-analysis, conducted in accordance with the PRISMA guidelines, aimed to investigate the benefits of current NPIs in the population with SCD. Methods: The online electronic databases, including MEDLINE, Cochrane Central Register of Controlled Trials, EMBASE, PsycInfo, and CINAHL, were searched to identify randomized controlled trials of NPIs for SCD. Intervention strategies were psychological and health-related education interventions, mind-body therapy, lifestyle modification, cognitive training, and multidomain interventions. Outcomes included subjective memory, objective memory, global cognitive function, psychological well-being, and mood. Study quality was determined using the criteria of the Cochrane collaboration’s tool. The Hedges’ g of change was analyzed. Results: Eighteen studies were included in this review and meta-analysis. Overall, psychological and health-related education interventions exhibited a medium effect on objective memory function (Hedges’ g = 0.53, p = 0.01). Cognitive training led to a small effect on objective memory, which was marginal statistically (Hedges’ g = 0.19, p = 0.05). In addition, cognitive training also significantly improved subjective memory performance (Hedges’ g = 0.49, p = 0.0003) and psychological well-being (Hedges’ g = 0.27, p = 0.03). Conclusion: Overall, the psychological intervention and cognitive training may be beneficial to cognitive function and psychological well-being. NPIs may be effectively implemented in older adults with SCD.

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Physical and cognitive training are able to prevent recognition memory deficits related to amyloid beta neurotoxicity

Cited by 20 publications

References 41 publications

The Reversal of Memory Deficits in an Alzheimer’s Disease Model Using Physical and Cognitive Exercise

The Reversal of Memory Deficits in an Alzheimer’s Disease Model Using Physical and Cognitive Exercise

Nonpharmacological treatment options for Alzheimer’s disease: from animal testing to clinical studies

Advances in Non-Pharmacological Interventions for Subjective Cognitive Decline: A Systematic Review and Meta-Analysis

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