Physical and Mental Fatigue in Subjects Recovered from COVID-19 Infection: A Case–Control Study

Elanwar, Rehab; Hussein, Mona; Magdy, Rehab; Eid, Ragaey A; Yassien, Ahmed; Abdelsattar, Ahmed S; Alsharaway, Laila A.; Fathy, Wael; Hassan, Amr; Kamal, Yasmine

doi:10.2147/ndt.s317027

Cited by 15 publications

(17 citation statements)

References 43 publications

(35 reference statements)

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“…Elanwar et al ( 11 ) defined participants as patients with post-COVID-19 if they were diagnosed with postinfectious fatigue syndrome (PIFS). In order to fulfill the definition of PIFS, patients had to have persistent fatigue for at least 6 months after recovery.…”

Section: Resultsmentioning

confidence: 99%

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Post-COVID-19 fatigue: A systematic review

Joli¹,

Buck²,

Zipfel³

et al. 2022

Front. Psychiatry

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Fatigue is recognized as one of the most commonly presented long-term complaints in individuals previously infected with SARS-CoV-2. This systematic review was performed to describe symptoms, etiology, possible risk factors related to post-COVID-19 fatigue and the therapeutic approaches used for the treatment of post-COVID-19 fatigue. For the systematic literature search the databases PubMed, Web of Science, Cochrane Library, and PsycInfo were used. All articles that met the inclusion criteria were analyzed for demographics, clinical data and treatment. Included were studies which focused on an adult population (18–65 years old); elderly patients and patients with chronic somatic diseases which can also cause fatigue were excluded. We identified 2,851, screened 2,193 and finally included 20 studies with moderate to high methodological quality, encompassing 5,629 participants. Potential risk factors for post-COVID-19 fatigue were old age, female sex, severe clinical status in the acute phase of infection, a high number of comorbidities, and a prediagnosis of depression/anxiety. Lastly, a possible autoimmune etiology was suspected. Several treatment approaches have been tested mostly in small and uncontrolled studies so far: a Chinese herbal formulation improved breathlessness and fatigue. Moreover, molecular hydrogen (H2) inhalation had beneficial health effects in terms of improved physical (6-min walking test) and respiratory function in patients with post-COVID-19. Patients also noticed improvement in fatigue after undergoing hyperbaric oxygen therapy (HBOT) and enhanced external counterpulsation (EECP). Lastly. muscle strength and physical function were improved after undergoing an 8-weeks biweekly physical therapy course including aerobic training, strengthening exercises, diaphragmatic breathing techniques, and mindfulness training. However, larger and controlled studies e.g., investigating the effect of physical and / or psychotherapy for patients with post-COVID-19 fatigue are urgently warranted.Systematic Review RegistrationUnique Identifier: CRD42022320676, https://www.crd.york.ac.uk/PROSPERO/.

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Section: Resultsmentioning

confidence: 99%

“…El Sayed et al ( 14 ) used the fatigue assessment scale. Elanwar et al ( 11 ), Townsend et al ( 15 – 17 ) used the Chalder fatigue scale providing a total fatigue score from 0-4. Scores of 2 or above are regarded as fatigued.…”

Section: Resultsmentioning

confidence: 99%

Post-COVID-19 fatigue: A systematic review

Joli¹,

Buck²,

Zipfel³

et al. 2022

Front. Psychiatry

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“…43 Moreover, one study found that PCS survivors with post-infectious fatigue syndrome, a condition highly similar to ME/CFS, had (i) higher scores of physical and mental fatigue, (ii) more abnormal neurophysiological assessments and (iii) more severe acute COVID-19 compared with controls (i.e., COVID-19 survivors without PCS). 47 Another study reported that depending on the diagnostic criteria, 13%-18% of discharged COVID-19 patients developed ME/ CFS at 6-month. 44 Similarly, in another study, 23% of SARS-CoV-2positive persons with no history of fatigue and cognitive dysfunction developed ME/CFS at 6-month.…”

Section: Myalgic Encephalomyelitis/chronic Fatigue Syndrome (Me/cfs)mentioning

confidence: 99%

Proposed subtypes of post‐COVID‐19 syndrome (or long‐COVID) and their respective potential therapies

Yong

Liu

2021

Reviews in Medical Virology

116

113

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The effects of coronavirus disease 2019 (COVID-19), a highly transmissible infectious respiratory disease that has initiated an ongoing pandemic since early 2020, do not always end in the acute phase. Depending on the study referred, about 10%-30% (or more) of COVID-19 survivors may develop long-COVID or post-COVID-19 syndrome (PCS), characterised by persistent symptoms (most commonly fatigue, dyspnoea, and cognitive impairments) lasting for 3 months or more after acute COVID-19. While the pathophysiological mechanisms of PCS have been extensively described elsewhere, the subtypes of PCS have not. Owing to its highly multifaceted nature, this review proposes and characterises six subtypes of PCS based on the existing literature. The subtypes are non-severe COVID-19 multi-organ sequelae (NSC-MOS), pulmonary fibrosis sequelae (PFS), myalgic encephalomyelitis or chronic fatigue syndrome (ME/CFS), postural orthostatic tachycardia syndrome (POTS), post-intensive care syndrome (PICS) and medical or clinical sequelae (MCS).Original studies supporting each of these subtypes are documented in this review, as well as their respective symptoms and potential interventions. Ultimately, the subtyping proposed herein aims to provide better clarity on the current understanding of PCS.

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“…PICOS (population, intervention, comparison, outcome and study designs) criteria were used as the inclusion criteria (see Table 1). Studies were required to fulfill the following five inclusion criteria: (1) MF was observed in participants; (2) studies published in English with the application of MBI, regardless of population characteristics, such as age, gender, and ethnicity; (3) randomized controlled trials (RCTs), non-randomized controlled trials (nRCTs) and non-randomized non-controlled trials (nRnCTs) with two or more groups and single-group trials; (4) MBI was used for intervention; (5) comparison was made without MBI and MF-inducing possibility. The exclusion criteria were as follows: (1) systematic review; (2) medical or neuropsychological studies.…”

Section: Eligibility Criteriamentioning

confidence: 99%

“…For example, since the emergence of the COVID-19 pandemic, peoples' mental health has been adversely affected. Studies have reported that people associated with the medical profession, such as nurses and recovered and isolated individuals, are likely to experience MF [1][2][3]. This prevalence of MF has implicated a lot of aspects of daily life.…”

Section: Introductionmentioning

confidence: 99%

Mindfulness-Based Interventions for the Recovery of Mental Fatigue: A Systematic Review

Cao

Geok

Roslan

et al. 2022

IJERPH

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Background: There is evidence that mindfulness-based interventions (MBI) can help one to recover from mental fatigue (MF). Although the strength model of self-control explains the processes underlying MF and the model of mindfulness and de-automatization explains how mindfulness training promotes adaptive self-regulation leading to the recovery of MF, a systematic overview detailing the effects of MBI on the recovery of MF is still lacking. Thus, this systematic review aims to discuss the influences of MBI on the recovery of MF. Methods: We used five databases, namely, PubMed, Web of Science, EBSCOhost, Scopus, and China National Knowledge Infrastructure (CNKI) for articles published up to 24 September 2021, using a combination of keywords related to MBI and MF. Results: Eight articles fulfilled all the eligibility criteria and were included in this review. The MBI directly attenuated MF and positively affected the recovery of psychology (attention, aggression and mind-wandering) and sports performance (handgrip, plank exercise and basketball free throw) under MF. However, the interaction did not reach statistical significance for the plank exercise. Therefore, the experience and duration of mindfulness are necessary factors for the success of MBI. Conclusions: mindfulness appears to be most related to a reduction in MF. Future research should focus on improving the methodological rigor of MBI to confirm these results and on identifying facets of mindfulness that are most effective for attenuating MF.

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Physical and Mental Fatigue in Subjects Recovered from COVID-19 Infection: A Case–Control Study

Cited by 15 publications

References 43 publications

Post-COVID-19 fatigue: A systematic review

Post-COVID-19 fatigue: A systematic review

Proposed subtypes of post‐COVID‐19 syndrome (or long‐COVID) and their respective potential therapies

Mindfulness-Based Interventions for the Recovery of Mental Fatigue: A Systematic Review

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