Aim: To examine whether informal caregiving is associated with increased risk of type 2 diabetes and whether job strain and social support at work modify this association. Research Methods: We pooled individual-participant data from three cohort studies (the French GAZEL cohort, the Swedish Longitudinal Occupational Survey of Health, and the British Whitehall II study), 21,243 individuals. Informal caregiving was defined as unpaid care for a closely related person. Job strain was assessed with the demand/control model and questions on coworker and supervisor support were combined in a measure of social support at work.Incident type 2 diabetes was ascertained using register-based, clinically assessed, and selfreported data. Results: 1,058 participants got type 2 diabetes during 10 years follow-up.Neither informal caregiving (OR=1.10, 95%CI:0.92-1.30) nor high job strain (OR=1.04, 95%CI:0.86-1.26) were associated with type 2 diabetes risk. Low social support at work was a risk factor for type 2 diabetes (OR=1.18, 95%CI:1.02-1.37). Individuals jointly exposed to informal caregiving and low social support at work were at higher risk of type 2 diabetes (OR=1.40, 95%CI:1.08-1.82) compared to individuals with no informal caregiving and high social support at work; test for interaction (multiplicative: p=0.04, additive: synergy index=10). Conclusion: Informal caregiving was not independently associated with risk of type 2 diabetes. However, low social support at work was a risk factor for type 2 diabetes and caregivers with low social support at work had an even higher risk of type 2 diabetes.