Physical and mental health in HIV-infected patients with virological success and long-term exposure to antiretroviral therapy

Sabranski, Michael; Erdbeer, Gesa; Sonntag, Ina; Stoehr, Albrecht; Horst, Heinz‐August; Plettenberg, Andreas; Lebherz, Lisa; Stellbrink, Hans‐Jürgen; Hoffmann, Christian

doi:10.1080/09540121.2020.1733466

Cited by 14 publications

(18 citation statements)

References 31 publications

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“…Sabranski et al found that depression was significantly related to a lower PCS. 30 In this study, we also found the independent influence of depression on the patient’s PCS. For the MCS, we only observed the independent role of depression and anxiety.…”

Section: Discussionsupporting

confidence: 67%

Quality of Life Assessment and Related Factors of HIV-Infected Patients in Hangzhou Using a Path Analysis Model: An Observational Study

Xing¹,

Yan²

2022

IJGM

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Objective This study aimed to examine which path among direct and indirect effects was more influential to the quality of life (QOL) for patients with human immunodeficiency virus (HIV). Methods An observational study among 951 individuals diagnosed with HIV was conducted in designated acquired immunodeficiency syndrome (AIDS) medical institutions in Hangzhou using simple random sampling technique. We collected the demographic data of patients and then evaluated their QOL by 12-Item Short-Form (SF-12) questionnaire survey. The two-stage least squares analysis was firstly performed to filter the independent influencing factors of Physical Component Summary (PCS) and Mental Component Summary (MCS). We then enrolled the PCS, MCS, and their influencing factors into the path analysis of QOL, and further revealed the direct and indirect effects of variables and examined the important path that was more influential on the patient’s QOL. Results The patient’s PCS, MCS, and quality of life showed a significant difference between groups in terms of education level and working condition (all P<0.05). Regression analysis showed that depression, age, education level, and treatment independently affected the PCS (all P<0.05), and depression and anxiety exerted an independent effect on the MCS (all P<0.05). Further path analysis integrating related variables showed that the main indexes of the goodness of fit implied the final model fit the data well. The path analysis showed that PCS and MCS exerted direct effects on the QOL (all P<0.001), especially the MCS (β=0.785), but other variables exerted no direct effects (all β=0, all P>0.05). It should be noted that anxiety presented an obvious indirect effect on the QOL (β=0.460), and its indirect effect was similar to the direct effect of PCS (β=0.471). Conclusion The MCS might exert a more important effect on the QOL of HIV patients. In addition, the indirect effect of anxiety on the QOL should not be ignored.

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Section: Discussionsupporting

confidence: 67%

Quality of Life Assessment and Related Factors of HIV-Infected Patients in Hangzhou Using a Path Analysis Model: An Observational Study

Xing¹,

Yan²

2022

IJGM

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“…The association between men’s sexual dysfunction and psychological health is real and proven [ 74 ]. Depression and anxiety, two of the most important mental factors associated with sexual dysfunction [ 74 ], are quite prevalent in HIV series triggered by HIV distress and related emotional stressors [ 5 , 75 , 76 ]. In this way, an intricate system composed by psychological, social and relational factors experienced by HIV-infected men are linked to the reduced interest in sexual activities [ 72 , 73 , 77 ], in addition a poor health status may further contribute to lowering sexual desire [ 39 , 41 , 78 ].…”

Section: Arousal and Sexual Desire Dysfunctionmentioning

confidence: 99%

“…A healthy and satisfactory sex life is considered an important element for a good health status and a gratifying quality of life [ 1 , 2 ]. Even though the relevance of a healthy sex life is a recognized issue also for people living with HIV [ 3 , 4 , 5 ], sexual problems tend to be unaddressed in HIV management [ 6 ]. Of note, different studies point out the higher sexual problems and overt sexual dysfunctions prevalence in people with HIV than in those who are HIV negative in both sexes [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

HIV and Sexual Dysfunction in Men

Vincentis

Tartaro

Rochira

et al. 2021

JCM

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Sexual issues tend to go unaddressed in human immunodeficiency virus (HIV) management, although overt sexual dysfunctions are more prevalent in people living with HIV than uninfected people. Erectile dysfunction is the most frequent sexual problem, with a prevalence of 30–50% even in men <40 years of age, but other issues such as loss of libido and ejaculatory disorders should not be overlooked. Peculiar factors related to HIV infection (e.g., fear of virus transmission, changes in body image, HIV-related comorbidities, HIV distress and stigma), alongside classical factors non-related to HIV, should be considered when approaching sexual problems in HIV patients. For this reason, the diagnostic and therapeutic workout of sexual dysfunction in the context of HIV requires a multidisciplinary approach, involving specialists in both infectious diseases and sexual medicine. This narrative review presents an overview of current knowledge on sexual dysfunction in HIV men, deepening the factors driving and taking part in these issues, providing advice for the clinical approach, and underlining the importance of caring for sexual health to improve the quality of life of HIV patients.

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“…These individuals were thus exposed to the first generation of nucleoside reverse transcriptase inhibitors (AZT and D4T) and protease inhibitors, which have been associated with body morphology changes and cardiovascular diseases [ 24 , 25 ]. In addition, ART duration and time living with diagnosed HIV infection have been associated with increased risk of multimorbidity [ 7 , 9 ], but also with psychological morbidity and lower quality of life [ 26 , 27 ], which should be considered as part of integrated HIV care. To the best of our knowledge, our study is the first to project time spent since ART initiation for an HIV population.…”

Section: Discussionmentioning

confidence: 99%

Projection of age of individuals living with HIV and time since ART initiation in 2030: estimates for France

et al. 2022

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Introduction: Thanks to antiretroviral treatment (ART), people living with HIV (PLHIV) are living longer and ageing. However, ageing involves increased risks of co-morbidities, which also depend on when PLHIV individuals started ART. To tackle the HIV age-related upcoming challenges, knowledge of the current and future age structure of the HIV population is needed. Here, we forecast the demographic profile of the adult population living with diagnosed HIV (aPLdHIV) in France until 2030, accounting for the impact of the ART initiation period on mortality. Methods: We used national data from the French Hospital Database on HIV (ANRS CO4-FHDH) and a sample of the National Health Data System to, first, characterize the aPLdHIV in 2018 and estimate their mortality rates according to age, sex and ART initiation period. Second, we used national HIV surveillance data to define three scenarios for the numbers of newly diagnosed HIV cases over 2019-2030: 30% decrease in HIV cases (S1), status quo situation (S2) and epidemic elimination (S3). We then combined these data using a matrix model, to project the age structure of aPLdHIV and time since ART initiation. Results: In 2018, there was an estimated 161,125 aPLdHIV (33% women), of which 55% were aged 50 or older (50+), 22% aged 60+ and 8% aged 70+. In 2030, the aPLdHIV would grow to 195,246 for S1, 207,972 for S2 and 167,221 for S3. Whatever the scenario, in 2030, the estimated median time since ART initiation would increase and age distribution would shift towards older ages: with 65-72% aPLdHIV aged 50+, 42-48% 60+ and 17-19% 70+. This corresponds to ∼83,400 aPLdHIV (28% women) aged 60+, among which ∼69% started ART more than 20 years ago (i.e. before 2010) and ∼39% ≥30 years ago (i.e. before 2000), and to ∼33,100 aPLdHIV (27% women) aged 70+, among which ∼72% started ART ≥20 years ago and ∼43% ≥30 years ago. Conclusions: By 2030, in France, close to 20% of the aPLdHIV will be aged 70+, of which >40% would have started ART more than 30 years ago. These estimates are essential to adapt co-morbidities screening and anticipate resource provision in the aged care sector.

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Physical and mental health in HIV-infected patients with virological success and long-term exposure to antiretroviral therapy

Cited by 14 publications

References 31 publications

Quality of Life Assessment and Related Factors of HIV-Infected Patients in Hangzhou Using a Path Analysis Model: An Observational Study

Quality of Life Assessment and Related Factors of HIV-Infected Patients in Hangzhou Using a Path Analysis Model: An Observational Study

HIV and Sexual Dysfunction in Men

Projection of age of individuals living with HIV and time since ART initiation in 2030: estimates for France

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