BackgroundTo evaluate the influence effect of physical and mental exercises on the mental health of the middle-aged and old people by using Meta analysis method. MethodsRetrieve databases such as CNKI, WanFang data, VIP Database for Chinese Technical Periodicals, Pubmed, Scopus, web of science, etc. to collect randomized controlled trials of the effect of physical and mental exercises on the mental health of the middle-aged and old people. ResultsThe effects of physical and mental exercises on the somatization and obsessive-compulsive symptoms of middle-aged and old women belongs to a medium effect, and their influence effect on symptoms such as interpersonal sensitivity, depression, anxiety, hostility, phobic anxiety, paranoid ideation belongs to a small effect. The effects of physical and mental exercises on the middle-aged people is greater than that of the old people for symptoms such as obsessive-compulsive, interpersonal sensitivity, depression, and hostility, which belongs to a small-to-medium effect. For the symptoms such as somatization, anxiety, and paranoid ideation, the influence effect of physical and mental exercises on the old is greater than that of the middle-aged, which belongs to a small-to-medium effect. The effects of physical and mental exercises for 45-60 minutes each time, 3 times a week, lasting 12-20 weeks on the middle-aged and old for symptoms such as somatization, obsessive-compulsive, interpersonal sensitivity, depression, anxiety, hostility, phobic anxiety, paranoid ideation is significant, which belongs to a small-to-medium effect. The effects of Tai Chi exercise on somatization, obsessive-compulsive, interpersonal sensitivity, depression, anxiety, hostility, phobic anxiety, paranoia and other symptoms of middle-aged and elderly people were small to medium. ConclusionPhysical and mental exercises have a small-to-medium effect on the middle-aged and old people for the symptoms such as somatization, obsessive-compulsive, interpersonal sensitivity, depression, anxiety, hostility, phobic anxiety, and paranoid ideation, but they have no significant effect on psychosis.