Physical approach for the reduction of dual radionuclide image subtraction artefacts in immunoscintigraphy

Ac, Perkins; Dr, Whalley; Jg, Hardy

doi:10.1097/00006231-198408000-00003

Cited by 21 publications

(5 citation statements)

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“…In this series, it was in few cases interpreted as a positive finding. To our knowledge, this artefact has not been described earlier concerning parathyroid scintigraphy [40]. …”

Section: Discussionmentioning

confidence: 71%

Comparison of Five Parathyroid Scintigraphic Protocols

Tunninen

Varjo

Schildt

et al. 2013

International Journal of Molecular Imaging

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Objectives. We compared five parathyroid scintigraphy protocols in patients with primary (pHPT) and secondary hyperparathyroidism (sHPT) and studied the interobserver agreement. The dual-tracer method (99mTc-sestamibi/123I) was used with three acquisition techniques (parallel-hole planar, pinhole planar, and SPECT/CT). The single-tracer method (99mTc-sestamibi) was used with two acquisition techniques (double-phase parallel-hole planar, and SPECT/CT). Thus five protocols were used, resulting in five sets of images. Materials and Methods. Image sets of 51 patients were retrospectively graded by four experienced nuclear medicine physicians. The final study group consisted of 24 patients (21 pHPT, 3 sHPT) who had been operated upon. Surgical and histopathologic findings were used as the standard of comparison. Results. Thirty abnormal parathyroid glands were found in 24 patients. The sensitivities of the dual-tracer method (76.7–80.0%) were similar (P = 1.0). The sensitivities of the single-tracer method (13.3–31.6%) were similar (P = 0.625). All differences in sensitivity between these two methods were statistically significant (P < 0.012). The interobserver agreement was good. Conclusion. This study indicates that any dual-tracer protocol with 99mTc-sestamibi and 123I is superior for enlarged parathyroid gland localization when compared with single-tracer protocols using 99mTc-sestamibi alone. The parathyroid scintigraphy was found to be independent of the reporter.

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“…In this series, it was in few cases interpreted as a positive finding. To our knowledge, this artefact has not been described earlier concerning parathyroid scintigraphy [40]. …”

Section: Discussionmentioning

confidence: 71%

Comparison of Five Parathyroid Scintigraphic Protocols

Tunninen

Varjo

Schildt

et al. 2013

International Journal of Molecular Imaging

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“…Images of both the 131I-labeled antibody distribution and the 99mTc-blood pool were recorded using a large-field gamma-camera fitted with a high-energy (400 keV max) collimator. Without moving the patient 120 MBq n3mIn was administerad to label the blood transferrin [20]. After a further 5 rain an additional blood pool view was recorded.…”

Section: T/36 Antibody and Normal Immunoglobulinmentioning

confidence: 99%

“…Data were stored by computer in a matrix of either 64 x 64 or 128 x 128 elements. After normalization of count rates the images were subtracted as previously described [20].…”

Section: T/36 Antibody and Normal Immunoglobulinmentioning

confidence: 99%

Localization of anti-osteogenic sarcoma monoclonal antibody 791T/36 in a primary human osteogenic sarcoma and its subsequent xenograft in immunodeprived mice

Pimm

Perkins²,

Armitage

et al. 1985

Cancer Immunol Immunother

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“…The fi rst clinical use of this antibody was carried out in patients with colorectal cancer [ 1 ]. The imaging was technically demanding since the fi rst antibodies were radiolabelled with I-131 and the long survival of the antibody in the circulation necessitated the use of background subtraction employing Tc-99m-labelled human serum albumin [ 2 ]. The work with monoclonal antibodies progressed with Nottingham undertaking some of the fi rst in vivo studies using In-111 and Tc-99m-labelled antibodies [ 3 , 4 ] and published one of the fi rst studies of SPECT antibody imaging [ 5 ].…”

mentioning

confidence: 99%

Nuclear Medicine in Nottingham: Antibodies, Gamma Probes and Drug Delivery

Perkins

2016

A History of Radionuclide Studies in the UK

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Physical approach for the reduction of dual radionuclide image subtraction artefacts in immunoscintigraphy

Cited by 21 publications

References 0 publications

Comparison of Five Parathyroid Scintigraphic Protocols

Comparison of Five Parathyroid Scintigraphic Protocols

Localization of anti-osteogenic sarcoma monoclonal antibody 791T/36 in a primary human osteogenic sarcoma and its subsequent xenograft in immunodeprived mice

Nuclear Medicine in Nottingham: Antibodies, Gamma Probes and Drug Delivery

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