Physical characterisation and component release of poly(vinyl alcohol)–tetrahydroxyborate hydrogels and their applicability as potential topical drug delivery systems

Murphy, Diarmaid J.; Sankalia, Mayur G.; Loughlin, Ryan; Donnelly, Ryan F.; Jenkins, Mark; Carron, Paul A M C

doi:10.1016/j.ijpharm.2011.11.018

Cited by 37 publications

(27 citation statements)

References 31 publications

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“…The G′ value is a measure of the "solid-like" nature of the base. Hardness can be defined as the force necessary to produce a given deformation (9). Thus, both G′ and hardness reflect the degree of cross-linking of the base and generally exhibit the same behavior.…”

Section: Discussionmentioning

confidence: 99%

Rheological Characterization of Cataplasm Bases Composed of Cross-Linked Partially Neutralized Polyacrylate Hydrogel

Wang

Zhang

et al. 2014

AAPS PharmSciTech

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Abstract. Viscoelasticity is a useful parameter for characterizing the intrinsic properties of the cross-linked polyacrylate hydrogel used in cataplasm bases. The aim of this study was to investigate the effects of various formulation parameters on the rheological characteristics of polyacrylate hydrogel. The hydrogel layers were formed using a partially neutralized polyacrylate (Viscomate ™ ), which contained acrylic acid and sodium acrylate in different copolymerization ratios, as the cross-linked gel framework. Dihydroxyaluminum aminoacetate (DAAA), which produces aluminum ions, was used as the crosslinking agent. Rheological analyses were performed using a "stress amplitude sweep" and a "frequency sweep". The results showed that greater amounts of acrylic acid in the structure of Viscomate as well as higher concentrations of DAAA and Viscomate led to an increase in the elastic modulus (G′). However, greater amounts of acrylic acid in the structure of Viscomate and higher concentrations of DAAA had an opposite on the viscous modulus (G″); this might be owing to higher steric hindrance. The results of this study can serve as guidelines for the optimization of formulations for cataplasms.

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Section: Discussionmentioning

confidence: 99%

Rheological Characterization of Cataplasm Bases Composed of Cross-Linked Partially Neutralized Polyacrylate Hydrogel

Wang

Zhang

et al. 2014

AAPS PharmSciTech

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“…MR (in percentage) was calculated by the percentage of the ratio between the area under the curve (AUC) of the peak to baseline (after the force is removed; AUC 2-3 ) and the baseline to peak (before the force is removed; AUC 1-2 ) from a force-time profile (15). MH (in Newton per millimeter), and DE (in Joules) were both determined based on force-distance profiles.…”

Section: Zetasizer Analysis Of Edta In Situ Hot Melt Dispersionmentioning

confidence: 99%

“…MH (in Newton per millimeter), and DE (in Joules) were both determined based on force-distance profiles. In particular, MH was elucidated from the gradient between the initial force and the maximum force attained, and the DE from the AUC (15). The matrix hardness, matrix resilience, and deformation energy for each EDTA-mPEG in situ melt dispersion mini-pellet formulations and Avicel ® -EDTA-mPEG in situ melt dispersion mini-pellet formulations was determined in triplicate.…”

Section: Zetasizer Analysis Of Edta In Situ Hot Melt Dispersionmentioning

confidence: 99%

Physicomechanical Characterization and Optimization of EDTA–mPEG and Avicel®–EDTA–mPEG In Situ Melt Dispersion Mini-Pellets

et al. 2013

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Abstract. The purpose of this study was to develop a physicomechanically customizable oral metal chelatory in situ hot melt dispersion mini-pellet entity which could be utilized within a binary drug delivery system. Avicel ® RC/CL type R-591 was included within the in situ hot melt dispersion mini-pellet formulations to determine the physicomechanical effect this compound would have on the mini-pellet formulations. The physicomechanical properties of the hot melt in situ mini-pellet formulations were mathematically fitting to regression curves. Physicomechanical adjustment of the in situ hot melt dispersion mini-pellet formulations could be mathematically predicted with the derived regression curve equations. The addition of Avicel ® RC/ CL type R-591 increased the physicomechanical properties such as matrix hardness and increased total disintegration of the in situ hot melt dispersion mini-pellet formulations. The utilization of a physicomechanically customizable oral metal chelatory in situ hot melt dispersion mini-pellet entity within a binary drug delivery system would to achieve a synergistically enhance the activity of a drug-carrying entity or a permeation enhancing entity within a single drug delivery unit. The experimental results indicated that weights of the pellets that achieved optimal hardness ranged between 35 and 45 mg. The melt-dispersion formulations disintegrated within shorter time periods and maintained higher ethylenediaminetetraacetic acid (EDTA) concentrations whereas melt-dispersion formulations which included Avicel ® had superior physicomechanical properties. Disintegration times ranged between 1,000 s for melt-dispersions containing EDTA and methyloxy polyethylene glycol 2000 (mPEG) only, to >6,000 s for melt-dispersions comprising EDTA, mPEG, and Avicel ® .

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“…The consequential internal associations and increases in viscosity are responsible for the semisolid state and resistance to movement. In the topical gel formulation, various polymeric materials, including polyacrylic acids (Carbomer) (5-7), sodium polyacrylamide (8), polyvinyl alcohol (9,10), and cellulose derivatives (11,12), are often used to obtain a viscous gel with network structure. However, the concentration of polymer is typically restricted to below 5% for safety concerns with pH preferably around 7 for optimum viscosity.…”

Section: Introductionmentioning

confidence: 99%

Influence of Colloidal Silicon Dioxide on Gel Strength, Robustness, and Adhesive Properties of Diclofenac Gel Formulation for Topical Application

Lü

Fassihi

2014

AAPS PharmSciTech

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The objective of this study is to identify the extent of stiffness, adhesiveness, and thixotropic character of a three-dimensional gel network of a 1% diclofenac sodium topical gel formulation in the presence and absence of colloidal silicon dioxide (CSD) and assess its ease of application and adhesiveness using both objective and subjective analysis. The 1% diclofenac gel was mixed with different amounts of CSD (e.g., 0.5, 1, 2, 3, and 5% w/w) and allowed to equilibrate prior to testing. The texture analyzer in combination with a cone-cap assembly was used to objectively investigate the changes in spreadability and adhesiveness of the gel system before and after addition of CSD. Results indicate that an increase in pliability and adhesiveness at levels ≥2 to ≤5% w/w of CSD dispersed in the gel ensues. For subjective analysis, gels with (2% w/w) CSD and in the absence of CSD were uniformly applied to a 20-cm(2) (5 cm × 4 cm) surface area on the forearms of healthy volunteers and vehicle preferences by the volunteers regarding ease of application, durability on the skin, compliance, and feelings concerning its textural properties were assessed. It appears that changes in the gel formulation with the addition of CSD enhance gel viscosity and bonding to the skin. Results further show that changes in physical and rheological characteristics of gel containing 2% w/w CSD did not significantly change subject preferences for the gel preparations. These findings may help formulators to have additional options to develop more robust and cost-effective formulations.

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Physical characterisation and component release of poly(vinyl alcohol)–tetrahydroxyborate hydrogels and their applicability as potential topical drug delivery systems

Cited by 37 publications

References 31 publications

Rheological Characterization of Cataplasm Bases Composed of Cross-Linked Partially Neutralized Polyacrylate Hydrogel

Rheological Characterization of Cataplasm Bases Composed of Cross-Linked Partially Neutralized Polyacrylate Hydrogel

Physicomechanical Characterization and Optimization of EDTA–mPEG and Avicel®–EDTA–mPEG In Situ Melt Dispersion Mini-Pellets

Influence of Colloidal Silicon Dioxide on Gel Strength, Robustness, and Adhesive Properties of Diclofenac Gel Formulation for Topical Application

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