Physical characteristics and polarographic reduction mechanism of some oxazolones

Ismaïl, Mohamed

doi:10.1139/v91-273

Cited by 8 publications

(4 citation statements)

References 15 publications

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“…The C-2 and C-4 positions of oxazolone are responsible for their various biological activities. Oxazolones perform an important role in the synthesis of several organic molecules, including amino acids, 5 amino alcohols, thiamine 6 and peptides. 7 Certain natural and synthetic oxazolones also possess important biological activities, such as anti-inflammatory, 8 antimicrobial, 9 anticancer, 10 anti-HIV, 11 anti-angiogenic, 12 anticonvulsant, 13 antitumor, antagonistic, sedative [14][15][16] and cardiotonic activity.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, spectroscopic characterization and pharmacological evaluation of oxazolone derivatives

et al. 2013

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A series of 4-aryl methylidene-2-phenyl/methyl-5-(4H)-oxazolone derivatives (2-7) have been synthesized using the reported method by condensation of aldehydes with N-benzoyl / N-acetyl glycine in the presence of zinc oxide as a catalyst and acetic anhydride at room temperature in ethanol. The compounds (2-6) are new derivatives. The structures of compounds were evaluated on the basis of 1H-NMR, 13C-NMR, EIMS, FT-IR and elemental analysis. All the compounds were screened for their antibacterial and urease inhibition activity. Antibacterial activity was tested by agar well diffusion method using Mueller Hinton Agar medium. Compound (2) showed excellent activity against S. aureus which has 16 mm (80%) inhibition and above 24 mm (70%) against S. typhi. The most active compound against E. coli was compound (6) having 20 mm (80%) inhibition followed by compound (5) having above 18 mm (70%) inhibition. Urease inhibition activity of all the compounds was determined by indophenol method. Compounds (3, 6) and (7) showed significant inhibition against Jacks bean urease

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Section: Introductionmentioning

confidence: 99%

Synthesis, spectroscopic characterization and pharmacological evaluation of oxazolone derivatives

et al. 2013

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“…À and subsequently the film-entrapped anion is assayed through an established electrochemical reduction mechanism [26,27] (Fig. 1), IEV could be considered qualitatively similar to cathodic adsorptive stripping voltammetry.…”

Section: Methodsmentioning

confidence: 99%

Application of Polymer‐Modified Hanging Mercury Drop Electrode in the Indirect Determination of Certain β‐Lactam Antibiotics by Differential Pulse, Ion‐Exchange Voltammetry

Prasad

Arora

2003

Electroanalysis

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A selective and sensitive polymer-modified electrode was developed for b-lactam antibiotics (cefaclor, amoxycillin and ampicillin) present in formulated and blood plasma samples for the quantitative analysis in aqueous environment. The detection was made using an ion-exchange voltammetric technique, in differential pulse mode, on poly(Nchloranil N,N,N',N'-tetramethylethylene diammonium dichloride)-modified hanging mercury drop electrode of a three-electrode system (PAR Model 303A) attached with a Polarographic Analyzer/Stripping Voltammeter (PAR Model 264A). Antibiotics, which are electroinactive compounds, were essentially converted to their electroactive oxazolone analogues through acid treatment under drastic conditions (0.1 mol L À 1 HCl, $ 85 8C, 2 h). These analytes in the form of their respective oxazolones were indirectly analyzed by oxazolone entrapment in the polymeric film through ion-exchange process at modified electrode surface (accumulation potential À 0.20 V (vs. Ag/AgCl), accumulation time 120 s, pH 7.4, KH 2 PO 4 -NaOH buffer (ionic strength 0.1 mol L À 1 ), scan rate 10 mV s À 1 , pulse amplitude 25 mV). The limit of detection of cefaclor-derived oxazolone was found to be 2.12 nmol L À 1 (0.82 ppb, S/N 3, RSD 3.21%) in terms of cefaclor (a representative b-lactam) concentration.

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“…They exhibit a wide spectrum of pharmacological activities such as anticancer [1], antitumor [2], antimicrobial [3], analgesic [4], antiinflammatory [5], antidepressant [6], anti-HIV [7,8], sedative [9,10], cardiotonic activity [11], antidiabetic and antiobesity [12,13]. Oxazolones are also involved in the synthesis of several organic molecules including amino acids, amino alcohols, thiamine, peptides and polyfunctional compounds [14,15]. They are also used in semiconductor devices such as electro photographic photoreceptors and in nonlinear optical materials.…”

Section: Introductionmentioning

confidence: 99%

Structural characterization and DFT studies of the highly disordered compound 2-phenyl-4-[4-(1,4,7,10-tetraoxa-13-azacyclopentadecyl)benzylidene]-5-oxazolone

Celepci¹

2019

Balıkesir Üniversitesi Fen Bilimleri Enstitüsü Dergisi

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In this study, the crystal and molecular structure of the compound 2-phenyl-4-[4-(1,4,7,10-tetraoxa-13-azacyclopentadecyl)benzylidene]-5-oxazolone was determined by the single-crystal X-ray diffraction method. The molecular structure of the compound consists of a N-phenyl-(aza-15-crown-5) moiety connected to the oxazol-5-one ring. A phenyl group is also linked to the oxazol-5-one fragment. Crystal structure is stabilized by C-H•••O type intermolecular hydrogen bonds, C-H•••O type intramolecular interaction and pi•••pi interactions. Theoretical studies such as molecular geometry, frontier molecular orbitals and molecular electrostatic potential were performed using the Density Functional Theory (DFT) method B3LYP/6-311G(d,p) basis set. Geometric parameters were compared with the experimental data and the compatibility was observed.

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Physical characteristics and polarographic reduction mechanism of some oxazolones

Cited by 8 publications

References 15 publications

Synthesis, spectroscopic characterization and pharmacological evaluation of oxazolone derivatives

Synthesis, spectroscopic characterization and pharmacological evaluation of oxazolone derivatives

Application of Polymer‐Modified Hanging Mercury Drop Electrode in the Indirect Determination of Certain β‐Lactam Antibiotics by Differential Pulse, Ion‐Exchange Voltammetry

Structural characterization and DFT studies of the highly disordered compound 2-phenyl-4-[4-(1,4,7,10-tetraoxa-13-azacyclopentadecyl)benzylidene]-5-oxazolone

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