Context. The Galactic globular cluster system is incomplete, especially in the low latitude regions of the Galactic bulge and disk. We report the physical characterization of twelve star clusters in the Milky Way, most of which are explored here for the first time. Aims. Our primary aim is determining their main physical parameters, such as reddening and extinction, metallicity, age, total luminosity, mean cluster proper motions (PMs), distances, in order to unveil the physical nature of these clusters. Methods. We study the clusters using optical and near-infrared (NIR) datasets. In particular, we use the Gaia Early Data Release 3 (EDR3) PMs in order to perform a PM-decontamination procedure and build final catalogues with probable-members. We match the Gaia EDR3 with the VISTA Variables in the Vía Láctea extended (VVVX) survey and Two Micron All Sky survey (2MASS) in the NIR, in order to construct complete NIR and optical colour-magnitude diagrams (CMDs) and investigate the clusters properties.Results. The extinctions are evaluated using existing reddening maps. We find ranges spanning 0.09 A K s 0.86 mag and 0.89 A G 4.72 mag in the NIR and optical, respectively. Adopting standard intrinsic red clump (RC) magnitudes and extinction values, we obtain first the distance modulus for each cluster and thereafter their heliocentric distances, that range from about 4 to 20 kpc. Therefore, we are able to place these clusters at 3 R G 14 kpc from the Galactic centre. The best PARSEC isochrone fit yields a metallicity range of −1.8 < [Fe/H] < +0.3 and an approximative age range of 2 < Age < 14 Gyr. Finally, we find that all clusters have low-luminosities, with −6.9 < M V < −3.5 mag. Conclusions. Based on our photometric analysis, we find both open clusters (OCs) and globular clusters (GCs) in our sample. In particular, we confirm the OC nature for Kronberger 100, while we classify Patchick 125 as a metal-poor GC, Ferrero 54 as a metalrich GC, and ESO 92-18 as a possible old OC or young GC. The classification as GC candidates is also suggested for Kronberger 99, Patchick 122, Patchick 126, Riddle 15, FSR 190 and Gaia 2. We also conclude that Kronberger 119 and Kronberger 143 might be either old OCs or young GCs.