Physical-chemical and in silico Studies of 1,4-dihydropyridine Derivatives

Abstract

The Doctoral Thesis is devoted to the study of 1,4-dihydropyridine (1,4-DHP) derivatives with various physicochemical methods and quantum chemical calculations. For the bromination reaction of the 1,4-DHP derivative with N-bromosuccinimide, previously undescribed intermediates were identified by NMR. An unusual temperature dependence of the AB system of the diastereotopic methylene protons of 1,4-DHP derivatives was observed by NMR. NMR and IR experiments revealed an anomalous |N-H| bond shortening upon hydrogen bond formation. The binding of 5′-mononucleotide monophosphates to cationic lipid-like 1,4-DHP derivatives has been characterized by isothermal titration calorimetry and NMR.