Physical comorbidities increase the risk of psychiatric comorbidity in multiple sclerosis

Marrie, Ruth Ann; Patten, Scott B.; Greenfield, Jamie; Svenson, Lawrence W.; Tremlett, Helen; Wolfson, Christina; Warren, Sharon; Profetto‐McGrath, Joanne; Fisk, John D.; Blanchard, James; Caetano, Patrícia; Elliott, Lawrence; Yu, Bo; Bhan, Virender; Svenson, Larry

doi:10.1002/brb3.493

Cited by 27 publications

(22 citation statements)

References 37 publications

(81 reference statements)

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“…We found the HR for incident anxiety in men decreased with an increasing followup period, although the association was significant throughout the follow-up. Another study also failed to find a significant association between diabetes and incident anxiety (defined by claimed data), which might be attributed to the five-year gap between baseline (1994) and follow-up (1999-2011) [29]. It is unclear why the positive association between diabetes and incident anxiety was observed in men only in our study.…”

Section: Discussioncontrasting

confidence: 79%

Incidence of Medication-Treated Depression and Anxiety Associated with Long-Term Cancer, Cardiovascular Disease, Diabetes and Osteoarthritis in Community-Dwelling Women and Men

et al. 2019

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Background: Long-term cancer, cardiovascular disease, diabetes and osteoarthritis may increase the risk of mental disorders, but which was more harmful and whether the associations differed between genders is unclear. Methods: We included 115,094 participants (54.3% women) aged 45-64 years from the 45 and Up Study who were free of depression, anxiety, and Parkinson's disease at baseline (2006)(2007)(2008)(2009). The incidence of depression and anxiety was identified using claim databases during follow-up until December 2016. Cox regression models were used to examine the association of cancer, cardiovascular disease, diabetes, and osteoarthritis at baseline with incident depression and anxiety. Findings: During a mean eight-year follow-up (958,785 person-year), the cumulative incidence of depression and anxiety was 12.5% and 5.9% in the healthy population. Hazard ratios ([HRs] (95% CI) versus healthy population) for incident depression associated with long-term cancer, cardiovascular disease, diabetes, and osteoarthritis were 1.19 (95% CI: 1.13-1.25), 1.08 (1.00-1.16)), 1.18 (1.09-1.28), and 1.94 (1.80-2.10), respectively. The corresponding HRs (95% CIs) for incident anxiety were 1.11 (1.03-1.20), 1.26 (1.14-1.39), 1.10 (0.98-1.24), and 2.01 (1.80-2.23), respectively. The positive association between cancer and incident depression was more evident in men (HR (95% CI): 1.24 (1.13-1.35) than in women (1.14 (1.07-1.21). Long-term diabetes was an independent risk factor for incident anxiety in men (1.21 (1.02-1.44) but not in women (1.09 (0.93-1.28)). Interpretation: Long-term osteoarthritis, cardiovascular disease, and cancer were independent risk factors for incident depression and anxiety in both genders with osteoarthritis having the highest relative risk.

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Section: Discussioncontrasting

confidence: 79%

Incidence of Medication-Treated Depression and Anxiety Associated with Long-Term Cancer, Cardiovascular Disease, Diabetes and Osteoarthritis in Community-Dwelling Women and Men

et al. 2019

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“…Table 2 summarizes the quality assessments performed for all studies along with a qualitative synthesis of the main study strengths and weaknesses as identified by the reviewers (for the full quality assessment tables see Tables S1 and S2). Most studies ( n = 11) were from North America 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, with an additional three studies from Europe 33, 34, 35, one from Asia 36 and one from the Middle‐East 37.…”

Section: Resultsmentioning

confidence: 99%

“…The second study by Marrie et al . 29 provided only fully adjusted estimates and found no association between diabetes and incident anxiety in an administrative database over 10 years of follow‐up. However, generalizability was limited by the fact that participants were sampled based on a diagnosis of multiple sclerosis or being a matched‐control for multiple sclerosis participants.…”

Section: Resultsmentioning

confidence: 99%

Investigating the longitudinal association between diabetes and anxiety: a systematic review and meta‐analysis

2018

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AimPrevious research has indicated an association between diabetes and anxiety. However, no synthesis has determined the direction of this association. The aim of this study was to determine the longitudinal relationship between anxiety and diabetes.MethodsWe searched seven databases for studies examining the longitudinal relationship between anxiety and diabetes. Two independent reviewers screened studies from a population aged 16 or older that examined either anxiety as a risk factor for incident diabetes or diabetes as a risk factor for incident anxiety. Studies that met eligibility criteria were put forward for data extraction and meta‐analysis.ResultsIn total 14 studies (n = 1 760 800) that examined anxiety as a risk factor for incident diabetes and two (n = 88 109) that examined diabetes as a risk factor for incident anxiety were eligible for inclusion in the review. Only studies examining anxiety as a risk factor for incident diabetes were put forward for the meta‐analysis. The least adjusted (unadjusted or adjusted for age only) estimate indicated a significant association between baseline anxiety with incident diabetes (odds ratio 1.47, 1.23–1.75). Furthermore, most‐adjusted analyses indicated a significant association between baseline anxiety and incident diabetes. Included studies that examined diabetes to incident anxiety found no association.ConclusionsThere was an association between baseline anxiety and incident diabetes. The results also indicate the need for more research to examine the direction of association from diabetes to incident anxiety. This work adds to the growing body of evidence that poor mental health increases the risk of developing diabetes.

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“…The average life expectancy of an MS patient has been shown to be 7-14 years less than the average person, however this reduction in life expectancy differs across MS populations 20. Several factors contribute to MS life expectancy including; early age of MS onset, sex, MS comorbidities, life style, accidents and suicide 20,21. As a complex disorder, management regimens should implement proactive life style modifications…”

mentioning

confidence: 99%

Predictors of Multiple Sclerosis Severity Score in Patients with Multiple Sclerosis

Albatineh¹,

Alroughani²,

Al-Temaimi³

2020

International Journal of MS Care

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Background: Multiple sclerosis (MS) is a demyelinating autoimmune disorder. Several factors have been shown to associate with MS clinical severity. Here we investigated the influence of different life style factors on MS clinical severity as assessed by the MS severity score (MSSS). Methods: A questionnaire was administered to 128 Kuwaiti MS patients to assess the association of smoking, supplement use, food allergy, physical activity and education with MSSS. A multiple linear regression model was used to test for associations. Regression model results were adjusted for gender, history of blood transfusion, MS age of onset, and marital status. Results: Smoking status, passive smoking and food allergy are not associated with MSSS. MS patients with a college education and graduate/professional degrees have on average 2.56 lower MSSS scores compared to those with less than high school education (β = −2.22 PV = 0.045, and β = −2.9 PV = 0.048, respectively). Patients who perform physical activity score on average 2.32 lower on the MSSS compared to those with no physical activity (Moderate exercise PV = 0.003, rigorous exercise PV = 0.001). Physical activity correlated significantly with MSSS outcomes (r2 = 0.452, PV < 0.001). Conclusions: Physical activity and educational level are significantly associated with reduced MSSS. Physical activity and educational level both contribute to a less severe MS clinical course. Current MS management protocols should consider life style changes to improve the quality of life of MS patients.

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Physical comorbidities increase the risk of psychiatric comorbidity in multiple sclerosis

Cited by 27 publications

References 37 publications

Incidence of Medication-Treated Depression and Anxiety Associated with Long-Term Cancer, Cardiovascular Disease, Diabetes and Osteoarthritis in Community-Dwelling Women and Men

Incidence of Medication-Treated Depression and Anxiety Associated with Long-Term Cancer, Cardiovascular Disease, Diabetes and Osteoarthritis in Community-Dwelling Women and Men

Investigating the longitudinal association between diabetes and anxiety: a systematic review and meta‐analysis

Predictors of Multiple Sclerosis Severity Score in Patients with Multiple Sclerosis

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