Physical Compatibility of Melphalan with Selected Drugs During Simulated Y-site Administration

Trissel, Lawrence A.; Martinez, Juan F.

doi:10.1093/ajhp/50.11.2359

Cited by 31 publications

(32 citation statements)

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“…Visual examinations were performed at each of the time points in normal, diffuse, fluorescent room light with the unaided eye, using a high-intensity monodirectional light g (Tyndall beam). 4 The turbidity of each sample was measured, using a formazin-calibrated, color-correcting turbidimeter. h Triplicate determinations were made on each of the samples, and particle size and content were assessed electronically.…”

Section: Physical Stabilitymentioning

confidence: 99%

Physical and Chemical Stability of Pemetrexed in Infusion Solutions

Zhang

Trissel

2006

Ann Pharmacother

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Pemetrexed is chemically stable for 2 days at room temperature and 31 days refrigerated in dextrose 5% injection and NaCl 0.9% injection. However, substantial numbers of microparticulates may form in pemetrexed diluted in the infusion solutions in PVC bags, especially during longer periods of refrigerated storage. Limiting the refrigerated storage period to the manufacturer-recommended 24 hours will limit particulate formation.

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Section: Physical Stabilitymentioning

confidence: 99%

Physical and Chemical Stability of Pemetrexed in Infusion Solutions

Zhang

Trissel

2006

Ann Pharmacother

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“…Physical instability was defined as visible particulate matter, haze, color change, or a change (increase or decrease) in measured turbidity of 0.5 nephelometric turbidity unit (NTU) or more. [9][10][11] The pH values of the test samples were measured using a calibrated pH meter (IonAnalyzer EA920; Orion Research, Boston, MA).…”

Section: Physical Stabilitymentioning

confidence: 99%

Physical and chemical stability of methotrexate, cytarabine, and hydrocortisone in Elliott’s B Solution for intrathecal use

Trissel

King

Zhang

et al. 2002

J Oncol Pharm Pract

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Intrathecal administration of methotrexate sodium and cytarabine with or without hydrocortisone sodium succinate is commonly used to treat metastatic spread of malignancies to the leptomeninges. The existing stability information on these drug combinations is inadequate due to the clinical use of increased doses of the drugs, as well as a change in the formulation of Elliott’s B Solution. The purpose of this study was to evaluate the physical and chemical stability of simulated high intrathecal doses of the subject drugs in the current formulation of Elliott’s B Solution. Methotrexate sodium 6, 12, and 15 mg was combined with cytarabine 100 mg with and without hydrocortisone sodium succinate 100 mg using Elliott’s B Solution as the intrathecal vehicle. Samples were stored at 4 and 23°C and evaluated for physical and chemical stability over 48 h. No precipitation or other evidence of physical instability was observed in any sample. Measured pH was 7.2- 7.5 in the samples and was sufficient to prevent methotrexate precipitation. High-performance liquid chromatography analysis found little or no loss of methotrexate and cytarabine in any sample and hydrocortisone at 4°C. At room temperature, hydrocortisone losses of 6-8% occurred in 48 h. The high doses of methotrexate sodium and cytarabine with or without hydrocortisone sodium succinate evaluated in this study are physically and chemically stable for 48 h at 4 and 23°C in Elliott’s B Solution.

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“…Combinations with no obvious visible signs of incompatibility were examined further using a Tyndall beam, h as described elsewhere. 7 The turbidity of the samples was measured using a colorcorrecting turbidimeter i immediately after preparation and at one and four hours after preparation. Triplicate determinations were recorded for each of the test samples.…”

Section: Methodsmentioning

confidence: 99%

“…7,8 Because propofol is an opaque white emulsion, an alternative approach to the evaluation of physical compatibility was used, as described previously [9][10][11] ; 10-mL samples (5 mL of ceftaroline fosamil test solution in a diluent mixed with 5 mL of undiluted propofol 10 mg/mL) were prepared for evaluation at each of the specified time points (immediately after preparation and at one and four hours). During the observation period, samples were stored at room temperature and exposed to normal laboratory fluorescent light.…”

Section: Methodsmentioning

confidence: 99%