Physical dependence and tolerance development to sustained low concentrations of morphine in mice

Morphine gives rise to a cascade of events in the nervous system affecting, among others, neurotransmitter metabolism. Tolerance develops for various effects shortly after administration of the drug. Also, physical dependence develops and can be demonstrated by precipitation of withdrawal reactions. Biochemical events in nervous tissue have been extensively studied during morphine treatment. This overview will focus upon brain protein metabolism since macromolecular events might be of importance for development of long-term effects, such as tolerance and physical dependence. Both dose- and time-dependent changes in brain protein synthesis and the syntheses of specific proteins have been demonstrated after morphine treatment, although methodological considerations are important. Different experimental models (animal and tissue culture models) are presented. It might be interesting to note that astroglial protein synthesis and the secretion of proteins to the extracellular medium are both changed after morphine treatment, these having been evaluated in astroglial enriched primary cultures and in brain tissue slices. The possibility is suggested that proteins released from astroglial cells participate in the communication with other cells, including via synaptic regions, and that such communication might of significance in modifying the synaptic membranes during morphine intoxication.

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Are astroglial cells involved in morphine tolerance?

Rönnbäck

Hanssoń

1988

Neurochem Res

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Physical dependence and tolerance development after chronic exposure to low levels of morphine in the rat

Kosersky

Kowolenko

Howes

1980

Pharmacology Biochemistry and Behavior

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Physical dependence and tolerance development to sustained low concentrations of morphine in mice

Cited by 2 publications

References 8 publications

Are astroglial cells involved in morphine tolerance?

Are astroglial cells involved in morphine tolerance?

Physical dependence and tolerance development after chronic exposure to low levels of morphine in the rat

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