Physical Effects of Sodium Hypochlorite on Bone: An Ex Vivo Study

Kerbl, Frank M.; DeVilliers, Patricia; Litaker, Mark S.; Eleazer, Paul D.

doi:10.1016/j.joen.2011.12.031

Cited by 39 publications

(30 citation statements)

References 16 publications

(16 reference statements)

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“…Several studies have proven the effectiveness of sodium hypochlorite (NaOCl) for bacterial reduction in addition to mechanical cleaning and shaping (2), but it must be confined to the root canal (3). Inadvertent extrusion of NaOCl can cause severe soft tissue irritation and necrosis and can compromise the integrity of cancellous bone (4,5). Numerous case reports of NaOCl accidents have confirmed that apical extrusion can cause severe reactions in biological tissues (3,(6)(7)(8)(9).…”

mentioning

confidence: 99%

Evaluation of 4 Different Irrigating Systems for Apical Extrusion of Sodium Hypochlorite

Yost¹,

Bergeron²,

Kirkpatrick³

et al. 2015

Journal of Endodontics

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confidence: 99%

Evaluation of 4 Different Irrigating Systems for Apical Extrusion of Sodium Hypochlorite

Yost¹,

Bergeron²,

Kirkpatrick³

et al. 2015

Journal of Endodontics

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“…Literature shows that the primary component of household bleach, sodium hypochlorite, can deproteinize the surface layer of cortical bone without disrupting the mineral composition (Boyde and Hobdell 1969; Broz et al 1997; Kerbl et al 2012; Otter et al 1988). As skullcaps were stored in a bleach-water solution to prevent algae from growing prior to treatment with the 250 kHz array but not the 500 kHz array, the initial thought was that this particulate formation during the 250 kHz experiments was primarily due to the bleach-induced fragile, chalky mineral layer on the external surface of the skull that precipitated off during histotripsy treatment.…”

Section: Discussionmentioning

confidence: 99%

Effect of Frequency and Focal Spacing on Transcranial Histotripsy Clot Liquefaction, Using Electronic Focal Steering

Gerhardson

Sukovich

Pandey

et al. 2017

Ultrasound in Medicine & Biology

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This in-vitro study investigated the effects of ultrasound frequency and focal spacing on blood clot liquefaction via transcranial histotripsy. Histotripsy pulses were delivered using two 256-element hemispherical transducers of different frequency (250 and 500 kHz) with 30 cm aperture diameters. A 4 cm diameter spherical volume of in-vitro blood clot was treated through three excised human skullcaps by electronically steering the focus with frequency proportional focal spacing: λ/2, 2λ/3 and λ with 50 pulses per location. The pulse repetition frequency (PRF) across the volume was 200 Hz, corresponding to a duty cycle of 0.08% (250 kHz) and 0.04% (500 kHz) for each focal location. Skull heating during treatment was monitored. Liquefied clot was drained via catheter and syringe in range of 6–59 mL in 0.9–42.4 minutes. The fastest rate was 16.6 mL/min. The best parameter combination was λ spacing at 500 kHz which produced large liquefaction through three skullcaps (23.1 ± 4.0, 37.1 ± 16.9 and 25.4 ± 16.9 mL) with the fast rates (3.2 ± 0.6, 5.1 ± 2.3 and 3.5 ± 0.4 mL/min). The temperature rise through the 3 skullcaps remained below 4 °C.

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“…Some authors have reported localized interdental bone necrosis after RCT (Reddy et al, 2014). Kerbl et al (2012) described in dogs the degradation of the organic matrix and grossly, caused significant changes in the bone cancellous structure, leaving it less dense and also large structural craters of apparent demineralization was found. Since FOBMD etiology is not fully understood and keeping in mind that in this study most patients had previous RCT on those sites, it is possible that NaOCl apical extrusion could explain the defect presence.…”

Section: Discussionmentioning

confidence: 99%

Focal Osteoporotic Bone Marrow Defects on Dental Implant Treated Patients: A 5-Year Period Prevalence Study

Simancas‐Pallares

Arévalo-Tovar

Marincola

2016

Int. J. Odontostomat.

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SIMANCAS-PALLARES, M.; ARÉVALO-TOVAR, L. & MARINCOLA, M.Focal osteoporotic bone marrow defects on dental implant treated patients: a 5-year period prevalence study. Int. J. Odontostomat., 10(1):23-28, 2016. ABSTRACT:Dental implants are considered the most effective treatment for teeth absence. Nevertheless, there are some bone conditions that could affect the osseointegration process, thus affecting the clinical and radiographic success rates. One of these conditions could be the Focal Osteoporotic Bone Marrow Defects. The objective of this study was to describe the 5-year period prevalence of Focal Osteoporotic Bone Marrow Defects (FOBMD) on dental implant treated patients. descriptive retrospective study was conducted. We systematically reviewed the clinical and radiographic data of treated patients in a Dental Implant Unit since January 2010 through December 2014. Once a FOBMD case was found, a detailed questionnaire was applied to the chart looking for demographic, medical and dental characteristics (clinical and radiographic). Also in a sub-sample histological analysis was carried out. Period prevalence (PP) was estimated calculating proportions and 95 % confidence intervals. Statistical analysis was performed using Stata v. 13.2 for Windows (Stata Corp., TX., USA). FOBMD 5-yPP was 9.52 % (CI 95 %: 6.87-13.5 %). We found 42 defects in 34 patients. Within the FOBMD patients, average age was 55.4±11.9 years, 67.64 % being females. Ninety-seven percent of the defects were located in the lower jaw, 79.41 % unilateral, 69.04 % single missed teeth lesions, 71.42 % affecting molar area and 59.52 % located on the right side of the maxillae. Histological analysis revealed inflammatory cells, dystrophic calcifications, hemorrhagic material and fatty cells for all the cases. FOBMD prevalence is low, so it should be considered as a rare condition but showing an exponential growing trend over the time. With no previous epidemiological data, these findings should be considered as a caution during x-ray examinations and treatment planning, in order to avoid surgical or prosthetic complications. Local factors as previous root canal treatments should be considered when elucidating reasons for its appearance.

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Physical Effects of Sodium Hypochlorite on Bone: An Ex Vivo Study

Cited by 39 publications

References 16 publications

Evaluation of 4 Different Irrigating Systems for Apical Extrusion of Sodium Hypochlorite

Evaluation of 4 Different Irrigating Systems for Apical Extrusion of Sodium Hypochlorite

Effect of Frequency and Focal Spacing on Transcranial Histotripsy Clot Liquefaction, Using Electronic Focal Steering

Focal Osteoporotic Bone Marrow Defects on Dental Implant Treated Patients: A 5-Year Period Prevalence Study

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