Physical, Endocrine, and Growth Factors in Lung Development

Wallace, Megan Jane; Hooper, Stuart B.; McDougall, Annie R A

doi:10.1016/b978-0-12-799941-8.00008-0

Cited by 4 publications

(10 citation statements)

References 233 publications

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“…Among chest and diaphragmatic movements, breathing movements regulate glottis dilation to ease the outflow of lung liquid and release pressure. Diaphragmatic contractions also control glottis aperture to limit the amount of liquid that flows out of the lungs (Wallace et al, 2015). This coordination is important because if lung liquid density is too low, it produces pulmonary hypoplasia, and in severe cases, alveolar collapse.…”

Section: Breathing Movementsmentioning

confidence: 99%

“…This coordination is important because if lung liquid density is too low, it produces pulmonary hypoplasia, and in severe cases, alveolar collapse. On the other hand, if lung liquid volume is too high-during the absence of fetal breathing movements (i.e., apnoea periods)-it unbalances intra-pulmonary pressure (Wallace et al, 2015). To maintain optimal intra-pulmonary pressure, the ratio between amniotic liquid and lung pressure should be close to zero.…”

Section: Breathing Movementsmentioning

confidence: 99%

“…Also, the fetus does not realize breathing movements in a vacuum. Amniotic composition and pressure co-vary with maternal metabolism, movement and clinical conditions (Wallace et al, 2015). For instance, caffeine or some medications like amphetamines increase rates of fetal breathing, while depressants of the nervous system like anesthetics, ethanol, and narcotics inhibit fetal breathing activity (Fraga and Guttentag, 2012).…”

Section: Breathing Movementsmentioning

confidence: 99%

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Pregnant Agencies: Movement and Participation in Maternal–Fetal Interactions

Quintero

Jaegher

2020

Front. Psychol.

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Pregnancy presents some interesting challenges for the philosophy of embodied cognition. Mother and fetus are generally considered to be passive during pregnancy, both individually and in their relation. In this paper, we use the enactive operational concepts of autonomy, agency, individuation, and participation to examine the relation between mother and fetus in utero. Based on biological, physiological, and phenomenological research, we explore the emergence of agentive capacities in embryo and fetus, as well as how maternal agency changes as pregnancy advances. We show that qualitatively different kinds of agency have their beginnings already in utero, and to what extent fetal and maternal movement modulate affectivity and individuation in pregnancy. We thus propose that mother and fetus are both agents who participate in pregnancy. Pregnancy then emerges as a relational developmental organization that anchors and holds its developing participants. We end the paper with reflections on ethical implications of this proposal, and suggestions for future research.

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Section: Breathing Movementsmentioning

confidence: 99%

Section: Breathing Movementsmentioning

confidence: 99%

Section: Breathing Movementsmentioning

confidence: 99%

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Pregnant Agencies: Movement and Participation in Maternal–Fetal Interactions

Quintero

Jaegher

2020

Front. Psychol.

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“…Trop2 expression is induced by factors known to be important for promoting fetal lung growth and development. During fetal life, the lungs are filled with lung liquid, which is secreted by the lungs and which maintains the fetal lungs in an expanded state, which is critical for promoting lung growth and development (Wallace et al, ). Trop2 mRNA levels are increased during accelerated fetal lung growth induced by an increase in lung expansion in fetal sheep, when there is a ∼5‐fold increase in cell proliferation (McDougall et al, ).…”

Section: Trop2 In Health and Diseasementioning

confidence: 99%

“…Trop2 expression is induced by factors known to be important for promoting fetal lung growth and development. During fetal life, the lungs are filled with lung liquid, which is secreted by the lungs and which maintains the fetal lungs in an expanded state, which is critical for promoting lung growth and development (Wallace et al, 2014). Trop2 mRNA levels are increased during and Epcam (open circles) mRNA levels during the pseudoglandular (dark grey bar, embryonic day 17; E17, n¼10), canalicular (light grey bar, E18, n¼8; E19, n¼7; and E20, n¼6), and saccular (black bar, E20 and E21, n¼6) stages of lung development in fetal rats.…”

Section: Trop2 In the Developing Lungmentioning

confidence: 99%

Trop2: From development to disease

McDougall

Tolcos

Hooper

et al. 2015

Developmental Dynamics

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Background: Trop2 was first discovered as a biomarker of invasive trophoblast cells. Since then most research has focused on its role in tumourigenesis because it is highly expressed in the vast majority of human tumours and animal models of cancer. It is also highly expressed in stem cells and in many organs during development. Results: We review the multifaceted role of Trop2 during development and tumourigenesis, including its role in regulating cell proliferation and migration, self-renewal, and maintenance of basement membrane integrity. We discuss the evolution of Trop2 and its related protein Epcam (Trop1), including their distinct roles. Mutation of Trop2 leads to gelatinous drop-like corneal dystrophy, whereas over-expression of Trop2 in human tumours promotes tumour aggressiveness and increases mortality. Although Trop2 expression is sufficient to promote tumour growth, the surprising discovery that Trop2-null mice have an increased risk of tumour development has highlighted the complexity of Trop2 signaling. Recently, studies have begun to identify the mechanisms underlying TROP2's functions, including regulated intramembrane proteolysis or specific interactions with integrin b1 and claudin proteins. Conclusions: Understanding the mechanisms underlying TROP2 signaling will clarify its role during development, aid in the development of better cancer treatments and unlock a promising new direction in regenerative medicine. Developmental Dynamics 244:99-109, 2015. V C 2014 Wiley Periodicals, Inc.

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