In light of recent global crises, including climate change, species extinction, the COVID-19 pandemic, social upheavals and energy supply challenges, this Special Issue of Biomimetics, entitled “Editorial Board Members’ Collection Series: Biomimetic Design, Constructions and Devices in Times of Change”, aims to explore innovative solutions through biomimetics. This collection features research on various biomimetic applications, such as the peptide-based detection of SARS-CoV-2 antibodies, ergonomic improvements for prolonged sitting, biomimicry industry trends, prosthetic foot functionality and agricultural machinery efficiency. The methods employed include peptide synthesis for diagnostics, simulation software for ergonomic designs, patent analysis for biomimicry trends and engineering discrete element methods for agricultural applications. The findings highlight significant advancements in health diagnostics, ergonomic safety, technological development, prosthetics and sustainable agriculture. The research underscores the potential of biomimetic approaches to address contemporary challenges by leveraging nature-inspired designs and processes. These insights contribute to a broader understanding of how biomimetic principles can lead to adaptive and sustainable solutions in times of change, promoting resilience and innovation across various fields.