Physical exercise and the functions of microRNAs

Santos, João Antonio Celestino dos; Veras, Allice Santos Cruz; Batista, Victor Rogério Garcia; Tavares, Maria Eduarda Almeida; Correia, Rafael Ribeiro; Suggett, Cara Beth; Teixeira, Giovana Rampazzo

doi:10.1016/j.lfs.2022.120723

Cited by 18 publications

(14 citation statements)

References 144 publications

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“…Calorie restriction (600 kcal/day) for 10 days induces remarkable changes in miRNA serum expression. For example, miR-122 is increased, while miR-19b or miR-22, miR-142, miR-143, and miR-145 levels are decreased during fasting ( 40 ). Physical exercise is another key component of lifestyle intervention in MAFLD.…”

Section: Discussionmentioning

confidence: 99%

Time for micro-RNAs in steatotic liver disease: a case–control study

Stoica,

Apostol,

Diculescu

et al. 2024

Front. Endocrinol.

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One of the challenges of modern-day living is to resist the temptation of overfeeding and sedentariness and maintain a healthy body and mind. On a favorable genetic and epigenetic background, a high-fat diet combined with lack of physical exercise constitutes the foundation for severe metabolic disturbances including steatotic liver disease. In our case–control study, we had the aim of establishing the role of selected micro-RNAs—miR-122, miR-192, miR-33a, and miR-33b—as superior biomarkers for the diagnosis and prognosis of steatotic liver in a 36-patient cohort compared to 12 healthy controls. Initial results confirmed the decline in miR-122 expression as fatty liver is progressing. However, combinations of ΔmiRs, such as ΔmiR33a_192, ΔmiR33a_122, and ΔmiR33b_122, correlate with ultrasound steatosis grade (R2 = 0.78) while others such as ΔmiR33b_122 provide a high specificity and sensitivity in fatty liver disease with an area under the curve (AUC) of 0.85. Compared to classical biomarkers, micro-RNAs can be used for both diagnostic and prognostic purposes as their diminished expression in severe cases of steatosis is associated with higher risk of emerging hepatocellular carcinoma. Manipulating micro-RNAs through agomirs or antagomirs can be the answer to the yet unsolved problem of efficient therapy in MAFLD.

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Section: Discussionmentioning

confidence: 99%

Time for micro-RNAs in steatotic liver disease: a case–control study

Stoica,

Apostol,

Diculescu

et al. 2024

Front. Endocrinol.

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“…The purpose of our study was to examine the acute response of a single bout of SS and HS training session in elite male cyclists, on the differential expression levels of target c-miRNAs. For this, we collected blood samples from a homogenous group of well-trained male cyclists pre- and post- SS and HS training session, investigating levels of preselected serum c-miRNAs previously associated with altered response to physical exercise by cardiac muscle function, inflammation or osteogenic differentiation, or promoting myogenesis, muscle proliferation or metabolic regulation ( Dos Santos et al, 2022 ). In our pool of c-miRNAs, we found three out of 24 miRNAs to be significantly altered after training sessions.…”

Section: Discussionmentioning

confidence: 99%

Acute response in circulating microRNAs following a single bout of short-sprint and heavy strength training in well-trained cyclists

Ryningen,

Rostad,

Ersvær

et al. 2024

Front. Physiol.

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Background: Heavy strength (HS) and short-sprint (SS) are commonly used training methods for competitive road cyclists, with the aim to improve the anaerobic power and short time cycling performance. Knowledge of how such training methods affects biochemical as well as molecular factors, are particularly important for determining individual recovery and long-term adaptations. The primary aim of the current study was to investigate the expression levels of small non-coding RNAs in response to HS and SS training in elite cyclists as potential biomarkers for individual optimal restitution time.Methods: Eleven well trained cyclists performed one session of HS training and one session of SS training on separate days. Blood samples were taken at baseline and 5 min, 1 h and 21 h post training. Along with physiological measurements and biochemical factors (serum creatine kinase, myoglobin, human growth hormone and plasma lactate), real-time quantitative PCR was used to explore whether HS and/or SS training influenced the abundance of 24 circulating miRNAs, in serum, associated with muscle development, angiogenesis, and/or inflammation.Results: Based on complete miRNA profiles from nine cyclists, the miRNAs showing most altered expression after both training sessions included the three striated muscle-specific miRNAs (myomiRs) miR-1-3p, 133a-3p and 133b-3p. While all three miRNAs showed significantly highest expression at 1 h post HS session, the acute effect of the SS session included a significantly higher level of miR-1-3p alone, at 5 min (highest), as well as at 1 h and 21 h post session. Correlation (negative) with biochemical markers was only shown for miR-133a-3p and CK (r = −0.786, p = 0.041) and between miR-133b-3p and [La−] (r = −0.711, p = .032), at 21 h post SS session.Conclusion: Our findings support that unique myomiRs are regulated by HS and SS training. Such knowledge may be important for individually adjusted restitution times.

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“…In this exploratory study, we have utilized serum samples collected over a period of 4 months during a college practice and game season and determined the relative expression of selected miRNAs in concussed players vs. matched (same position in the field) controls. Since physical exercise profoundly affects miRNA expression ( 43 – 45 ), we reasoned that the best control for the concussed players would be a player exposed to a similar physical exercise but without TBI. The serum in control players was obtained at the same time as the concussed players ( Table 3 ).…”

Section: Discussionmentioning

confidence: 99%

Serum microRNAs associated with concussion in football players

et al. 2023

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Mild Traumatic Brain Injury (mild TBI)/concussion is a common sports injury, especially common in football players. Repeated concussions are thought to lead to long-term brain damage including chronic traumatic encephalopathy (CTE). With the worldwide growing interest in studying sport-related concussion the search for biomarkers for early diagnosis and progression of neuronal injury has also became priority. MicroRNAs are short, non-coding RNAs that regulate gene expression post-transcriptionally. Due to their high stability in biological fluids, microRNAs can serve as biomarkers in a variety of diseases including pathologies of the nervous system. In this exploratory study, we have evaluated changes in the expression of selected serum miRNAs in collegiate football players obtained during a full practice and game season. We found a miRNA signature that can distinguish with good specificity and sensitivity players with concussions from non-concussed players. Furthermore, we found miRNAs associated with the acute phase (let-7c-5p, miR-16-5p, miR-181c-5p, miR-146a-5p, miR-154-5p, miR-431-5p, miR-151a-5p, miR-181d-5p, miR-487b-3p, miR-377-3p, miR-17-5p, miR-22-3p, and miR-126-5p) and those whose changes persist up to 4 months after concussion (miR-17-5p and miR-22-3p).

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Physical exercise and the functions of microRNAs

Cited by 18 publications

References 144 publications

Time for micro-RNAs in steatotic liver disease: a case–control study

Time for micro-RNAs in steatotic liver disease: a case–control study

Acute response in circulating microRNAs following a single bout of short-sprint and heavy strength training in well-trained cyclists

Serum microRNAs associated with concussion in football players

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