Physical Exercise as Therapy for Type 2 Diabetes Mellitus: From Mechanism to Orientation

Yang, Dan; Yang, Yifan; Li, Yanlin; Han, Rui

doi:10.1159/000500110

Cited by 110 publications

(82 citation statements)

References 68 publications

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“…This gene has the responsibility in improving the skeletal muscle capability by increasing glucose uptake and transport .14 It also plays a role in body mass index (BMI) optimization, DNA methylation modulation, as well as upregulating some cytokines secretion that correlates with exercises and metabolic diseases. [15][16][17][18] The results of the current study are in line with the findings in a study performed by Paramitha 19 in 2014 where they showed a significant relationship between physical activity and blood glucose levels in DM-2 patients in Karanganyar District General Hospital, Surakarta with p = 0.001 and r =-0.433 and also a study by Nurayati and Adriani 20 in Surabaya city in 2007. Recently, DM-2 risk is increasing with a change in the lifestyle that adopts low activity level and high carbohydrate consumption.…”

Section: Discussionsupporting

confidence: 91%

Physical Activities Decrease Fasting Blood Glucose Level in Diabetes Mellitus Type 2 Patients: Use of International Physical Activity Questionnaire (IPAQ) in Rural Area

Putri

Persariningrat

Surialaga

et al. 2019

mkb

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An increase in the incidence of diabetes mellitus type 2 (DM-2) has been observed from 1.1% in 2007 to 1.5% in 2018 with incidents occur in both urban areas and rural areas of Indonesia. Garut as one of the rural areas in Indonesia is the fourth district with the highest DM-2 incidence in West Java Province, Idnonesia. Physical activity is considered to affect the glycemic control and weight loss in DM-2 patients. Therefore, the purpose of this study was to determine the relation between the physical activity level and blood glucose level in DM-2 patients in Garut, Indonesia. This was a cross-sectional observational analytic study on 46 DM-2 patients who were the members of the Garut Branch of the Indonesian Diabetes Association (PERSADIA), in May 2018. The physical activity level was measured using the International Physical Activity Questionnaire (IPAQ) while the blood glucose level was measured using fasting blood glucose level test. Data were then analyzed using analysis of variance test. Results showed that most participants had a low level of physical activity (52.2%) while the lowest fasting blood glucose was obtained from patients with high physical activity (98.63±11.6), compared to those with moderate and low physical activity levels (123.43±20.16 and 164.21±19.04 mg/dL, respectively) with p=0.000 (p<0.05). Lifestyle changes, especially in the form of the lack physical activity, were seen alsonin the rural area in Indonesia. High physical activity level is the most effective measure to lower fasting blood glucose level in DM-2 patients. AbstrakKejadian pasien diabetes mellitus tipe 2 (DM-2) pada tahun 2018 (1,5%) mengalami peningkatan dibanding dengan tahun 2007 (1,1%), terjadi baik di daerah perkotaan dan pedesaan di Indonesia. Garut sebagai salah satu daerah pedesaan di Indonesia adalah salah satu kabupaten dengan insidens DM-2 terbesar keempat di Jawa Barat-Indonesia. Aktivitas fisik dianggap memengaruhi kontrol glikemik dan penurunan berat badan pada pasien DM-2. Oleh karena itu, tujuan dari penelitian ini adalah mengetahui hubungan tingkat aktivitas fisik dengan kadar glukosa darah pada pasien DM-2 di Garut-Indonesia. Subjek penelitian ini adalah 46 pasien DM-2 yang tergabung dalam Persatuan Diabetes Indonesia (PERSADIA), cabang Kabupaten Garut, pada Mei 2018. Metode penelitian yang digunakan adalah analitik observasional dengan metode cross-sectional. International Physical Activity Questionnaire (IPAQ) sebagai alat untuk mengukur tingkat aktivitas fisik, selain itu dilakukan pengukuran kadar glukosa darah puasa. Data dianalisis menggunakan analysis of variance test. Hasil penelitian menunjukkan bahwa sebagian besar peserta memiliki tingkat aktivitas fisik yang rendah (52,2%) dan glukosa darah puasa terendah diperoleh dari pasien dengan aktivitas fisik yang tinggi (98,63±11,6) dibanding dengan aktivitas fisik sedang dan rendah (123,43±20,16 dan 164,21±19,04 mg/dL), dengan p=0.000 (p<0,05). Perubahan gaya hidup terutama kurangnya aktivitas fisik juga terjadi di daerah pedesaan di Indonesia dan akti...

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Section: Discussionsupporting

confidence: 91%

Physical Activities Decrease Fasting Blood Glucose Level in Diabetes Mellitus Type 2 Patients: Use of International Physical Activity Questionnaire (IPAQ) in Rural Area

Putri

Persariningrat

Surialaga

et al. 2019

mkb

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“…[67][68][69] PA plays a major role in the prevention and control of insulin resistance, prediabetes, GDM, T2DM, and diabetes related health complications. 70 Exercise is used for the prevention, 71 and treatment of T2DM [72][73][74][75][76][77][78] by improving glycemic control. 43,[79][80][81][82][83][84][85][86] It is a comprehensive element of diabetes management.…”

Section: Management Of T2dmmentioning

confidence: 99%

“…The mechanism of exercise in the improvement of T2DM is very complex and not completely known. 75 During an exercise, there is a complex biological response because almost all organs and systems are involved in the interactions that lead to adaptations at the levels of genetic, metabolic, and neuromuscular. 106 There are a few ways that PA could decrease BG levels.…”

Section: The Physiological Effects Of Physical Activity In T2dmmentioning

confidence: 99%

“…As explained above, evidence has shown that PA improves insulin sensitivity in T2DM patients. 9,13,75,79,84,[105][106][107]114,115,117,129,139,140,[153][154][155][156][157][158][159][160][161] The increased insulin sensitivity makes the muscle cells better able to use any available insulin to take up glucose during, and after exercise. In fact, whenever muscles cells contract during exercise, the muscle cells are able to take up glucose and use it for energy, whether insulin is available or not.…”

Section: The Physiological Effects Of Physical Activity In T2dmmentioning

confidence: 99%

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<p>Antidiabetic Effects of Physical Activity: How It Helps to Control Type 2 Diabetes</p>

Wake¹

2020

DMSO

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Despite the improvements in clinical care of the patients, research updates, and public health interventions, there is still an increase in the prevalence, incidence, and mortality because of diabetes mellitus (DM). DM is a public health problem in both developed and developing countries. It has increased alarmingly, putting this disease in the dimension of an epidemic. Diabetes is associated with several complications which increase the risk of many serious health problems on the other side. Therefore, this review was aimed to discuss the antidiabetic effects of physical activity (PA) on type 2 DM (T2DM) by summarizing the significant studies on this topic. This review found that several studies have recommended the utilization of PA for the effective management of T2DM. PA is a non-pharmacologic therapy which is a significant strategy for the management of T2DM and is an appropriate lifestyle modification approach to be practiced by these patients. The studies showed that PA has antidiabetic effects which are evidenced by its substantial role in improving the blood glucose (BG) levels of the individuals with T2DM where it helps them to control their levels of glucose in the blood. It plays a significant role in glycemic control of this disease by lowering the BG levels through possible mechanisms such as decreasing insulin resistance, increasing production of glucose transporter type 4 (GLUT-4), lowering visceral adipose tissue (VAT), increasing pancreatic β-cell functions, using glucose for energy, and so on. In turn, the controlled glycemia helps to prevent the complications associated with uncontrolled T2DM and this would further improve the overall health of the patients and the burden on the health professionals as well. Finally, this review concludes that PA is the cornerstone in the management of T2DM. It also suggests that more attention is needed to its significance in the prevention, glycemic control, and its role in the management of the morbidity and mortality associated with T2DM. Practical PA recommendations and suggestions for the future direction of research in this area are also provided.

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“…Das ultraschnelle Insulin aspart hat infolge rascherer Absorption eine doppelt so schnelle Anflutung im Blut und damit insbesondere in den ersten 30 Da sehr viele Menschen mit Typ-2-Diabetes neben der chronischen Hyperglykämie eine Vielzahl von weiteren vaskulären Risikofaktoren aufweisen, ist die Behandlung dieser Menschen komplex und soll alle vaskulären Risikofaktoren individuell berücksichtigen. Um dies deutlicher hervorzuheben, wurde der bisherige Therapiealgorithmus erweitert, um wesentliche kardiovaskuläre Risiken detaillierter zu adressieren (siehe dazu auch gesondertes Kapitel Lipidstoffwechselstörungen in diesen Praxisempfehlungen).…”

Section: Insulineunclassified

Therapie des Typ-2-Diabetes

Landgraf

Aberle

Birkenfeld

et al. 2019

Diabetologie und Stoffwechsel

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Physical Exercise as Therapy for Type 2 Diabetes Mellitus: From Mechanism to Orientation

Cited by 110 publications

References 68 publications

Physical Activities Decrease Fasting Blood Glucose Level in Diabetes Mellitus Type 2 Patients: Use of International Physical Activity Questionnaire (IPAQ) in Rural Area

Physical Activities Decrease Fasting Blood Glucose Level in Diabetes Mellitus Type 2 Patients: Use of International Physical Activity Questionnaire (IPAQ) in Rural Area

<p>Antidiabetic Effects of Physical Activity: How It Helps to Control Type 2 Diabetes</p>

Therapie des Typ-2-Diabetes

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