Physical exercise attenuates cognitive decline and reduces behavioural problems in people with mild cognitive impairment and dementia: a systematic review

Law, Chun-Kit; Lam, F.K.; Chung, Raymond C.K.; Pang, Marco Yiu Chung

doi:10.1016/j.jphys.2019.11.014

Cited by 156 publications

(104 citation statements)

References 85 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Analysis of multiple indexes of cognitive function after 3 and 6 months of treatment showed that Baduanjin improved the cognitive function of patients with mild cognitive impairment. These therapeutic effects of Baduanjin were similar to those of other physical exercises 36 and combined cognitive and physical interventions. 37…”

Section: Discussionsupporting

confidence: 67%

Systematic review and meta-analysis of randomized controlled trials assessing the impact of Baduanjin exercise on cognition and memory in patients with mild cognitive impairment

Liu

Nie

et al. 2020

Clin Rehabil

View full text Add to dashboard Cite

Objective: To determine the effectiveness of Baduanjin exercise in improving cognition and memory in patients with mild cognitive impairment. Data sources: Relevant English- and Chinese-language studies published until 15th September 2020 were retrieved from the PubMed, Web of Science, Cochrane Library, Embase, EBSCOhost, OVID, National Knowledge Infrastructure, WANFANG DATA, VIP Information, and SinoMed databases. Review methods: Randomized controlled trials assessing Baduanjin exercise in patients with mild cognitive impairment were included. Two researchers independently identified eligible studies and extracted data. Risk-of-bias assessment was performed using the Cochrane Risk of Bias Tool. Results: This study included 16 randomized controlled trials (1054 participants) from China that used Chinese versions of standardized tests. Most studies had no significant bias, and only one study had a high risk of bias in the random allocation category. Compared with conventional therapy alone, Baduanjin plus conventional therapy significantly improved the Montreal Cognitive Assessment and Mini-Mental State Examination scores after 6 months of treatment ( P < 0.00001 for both), significantly decreased the tau/Aβ1–42 ratio in the cerebrospinal fluid ( P < 0.00001), and significantly improved some dimensional scores on the Wechsler Memory Scale and the auditory verbal learning test scores at 6 months ( P < 0.05 for all). Conclusion: Compared with conventional therapy, Baduanjin plus conventional therapy significantly improved cognitive and memory function in patients with mild cognitive impairment.

show abstract

Section: Discussionsupporting

confidence: 67%

Systematic review and meta-analysis of randomized controlled trials assessing the impact of Baduanjin exercise on cognition and memory in patients with mild cognitive impairment

Liu

Nie

et al. 2020

Clin Rehabil

View full text Add to dashboard Cite

show abstract

“…All 7 studies that evaluated motivation or compliance agreed that the exergames increased or enhanced the participants’ motivation to engage in rehabilitation activities. Although exercise therapy has been recommended to improve the cognitive and physical functions in people with dementia or mild cognitive impairment in recent years [ 88 ], there are still many barriers to exercise, such as lack of motivation and limited access to exercise facilities [ 89 ]. Exergames provide sensory feedback through auditory, visual, and tactile stimulation [ 90 ], and can further maintain the motivation of individuals [ 66 ].…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of Exergaming in Improving Cognitive and Physical Function in People With Mild Cognitive Impairment or Dementia: Systematic Review

Zhao

Feng

et al. 2020

JMIR Serious Games

View full text Add to dashboard Cite

Background Individuals with mild cognitive impairment and dementia have impaired physical and cognitive functions, leading to a reduced quality of life compared with those without such impairment. Exergaming, which is defined as a combination of exercise and gaming, is an innovative, fun, and relatively safe way to exercise in a virtual reality or gaming environment. Therefore, exergaming may help people living with mild cognitive impairment or dementia to overcome obstacles that they may experience regarding regular exercise and activities. Objective The aim of this systematic review was to review studies on exergaming interventions administered to elderly individuals with mild cognitive impairment and dementia, and to summarize the results related to physical and cognitive functions such as balance, gait, executive function, and episodic memory. Methods We searched Cochrane Central Register of Controlled Trials (CENTRAL), Medline, Embase, PsycINFO, Amed, and Nursing Database for articles published from the inception of the respective databases to January 2019. We included all clinical trials of exergaming interventions in individuals with mild cognitive impairment and dementia for review. The risk of bias was independently evaluated by two reviewers using the Cochrane Collaboration and Risk of Bias in Non-randomized Studies of Interventions tools. Results Ten studies involving 702 participants were included for review. There was consistent evidence from 7 studies with a low risk of bias showing statistically significant effects of exergaming on cognitive functioning in people with mild cognitive impairment and dementia. With respect to physical function, 3 of 5 full-scale studies found positive results, and the intensity of most games was classified as moderate. Conclusions Overall, exergaming is an innovative tool for improving physical and cognitive function in people with mild cognitive impairment or dementia, although there is high heterogeneity among studies in terms of the duration, frequency, and gaming platform used. The quality of the included articles was moderate to high. More high-quality studies with more accurate outcome indicators are needed for further exploration and validation of the benefits of exergaming for this population.

show abstract

“…Exploring ways of preventing, or delaying the onset this disease is a pragmatic strategy. Regular exercise can reduce the occurrence of AD in the healthy elderly population and delay the progression of MCI, although the bene cial effect is not apparent in the clinical treatment of AD [6][7][8][9][10][11]. The underlying mechanism has not yet to be determined.…”

Section: Discussionmentioning

confidence: 99%

“…Currently, non-pharmacological interventions are receiving substantial interest due to the inability to develop AD therapeutic drugs and vaccines [2]. Epidemiological and clinical studies show that physical activity improves cognition during healthy aging [4][5][6], as well as individuals with mild cognitive impairment [7][8][9]. However, exercise therapy has not been shown to exert explicitly bene cial outcomes on patients with AD [10,11].…”

Section: Introductionmentioning

confidence: 99%

Beneficial effects of voluntary exercise therapy on an Alzheimer’s mouse model are dependent on aquaporin 4-mediated glymphatic transport

Liu

Feng

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Epidemiological and clinical evidence suggest there is an effective time window for the ability of exercise to slow the progression of Alzheimer's disease (AD). Astrocyte aquaporin-4 (AQP4) dependent glymphatic transport is necessary for clearance of extracellular amyloid-β (Aβ) from the brain. The purpose of this study is to explore whether this Aβ clearance mechanism is involved in the time-dependent benefit of exercise on Aβ related pathology. Method: 3- and 7-month-old male wild type (WT) mice, APP695swe/PS1-dE9 (APP/PS1) mice and AQP4 knockout (AQP4−/−)/APP/PS1 mice received voluntary wheel exercise intervention for 2 months, followed by behavioral and pathological analyses.Results: 9-month-old APP/PS1 mice showed enhanced reactive astrogliosis, accompanied with widespread loss of perivascular AQP4 polarization, when compared to 5-month-old APP/PS1 mice. Voluntary exercise improved AQP4 polarity and glymphatic transport, reduced glial inflammation and brain Aβ plaque load, plus alleviated synapse protein loss and cognitive deficits in 5-month-old, but not 9-month-old, APP/PS1 mice. Exercise intervention did not mitigate glymphatic transport dysfunction, Aβ accumulation and cognitive impairment in AQP4−/−/APP/PS1 mice at 5 or 9 months of age. Conclusion: These results have revealed that AQP4-dependent glymphatic transport is an influential factor in the timeliness of voluntary exercise ability to alleviate Aβ pathology, potentially offering a new target for the early prevention of the disease.

show abstract

Physical exercise attenuates cognitive decline and reduces behavioural problems in people with mild cognitive impairment and dementia: a systematic review

Cited by 156 publications

References 85 publications

Systematic review and meta-analysis of randomized controlled trials assessing the impact of Baduanjin exercise on cognition and memory in patients with mild cognitive impairment

Systematic review and meta-analysis of randomized controlled trials assessing the impact of Baduanjin exercise on cognition and memory in patients with mild cognitive impairment

Effectiveness of Exergaming in Improving Cognitive and Physical Function in People With Mild Cognitive Impairment or Dementia: Systematic Review

Beneficial effects of voluntary exercise therapy on an Alzheimer’s mouse model are dependent on aquaporin 4-mediated glymphatic transport

Contact Info

Product

Resources

About