Physical exercise for people with Parkinson’s disease: a systematic review and network meta-analysis

Ernst, Moritz; Folkerts, Ann-Kristin; Gollan, Romina; Lieker, Emma; Caro-Valenzuela, Julia; Adams, Anne; Cryns, Nora; Monsef, Ina; Dresen, Antje; Roheger, Mandy; Eggers, Carsten; Skoetz, Nicole; Kalbe, Elke

doi:10.1002/14651858.cd013856.pub2

Cited by 48 publications

(45 citation statements)

References 336 publications

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“…Becker and Rietdyk 22 also briefly mentioned, because of the link between fatigue increasing the risk of trips, the relevance of intervention programs in improving endurance capacity. Those suggestions confirm the cumulative and systematic evidence on exercise effectiveness on walking ability, improving performance, and reducing falls in older and PD individuals 25,26 . Specifically considering intervention focusing on the mechanisms of gait stability, van Leeuwen et al 23 discussed detailed strategies to improve foot placement and stance leg control.…”

Section: Potential Interventions and Future Directionsupporting

confidence: 55%

Editorial: Effects of aging on locomotor patterns

Santos

Orcioli‐Silva

2022

BJMB

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Aging and age-associated neurological diseases, such as Alzheimer's disease and Parkinson's disease, may impair walking performance. Changes in walking performance are related to an increase in fall risk, institutionalization, hospitalization, survival rate, and mortality. Due to the increase in the older population, especially age-related diseases, the number of research aiming at understanding the mechanisms behind such changes and tools (interventions) to improve walking performance has increased substantially. In this special issue, we target to compile information and strengthen the discussion about whether and how aging and AD, and PD affect walking (the most common way of human locomotion), and potential interventions to improve walking in these populations. A total of 5 studies composed this special issue, including 4 original papers and 1 review

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Section: Potential Interventions and Future Directionsupporting

confidence: 55%

Editorial: Effects of aging on locomotor patterns

Santos

Orcioli‐Silva

2022

BJMB

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“…Many different types of exercises have been investigated, including aerobic exercises like walking and treadmill exercise, strength interventions, balance and gait interventions, hydrotherapy, Pilates, dance, boxing, tai chi and other multimodal exercise combinations. Systematic reviews have confirmed the relative benefits of different types of exercise on subjective quality of life (QoL) 8,9 . Motor benefits have also been found 9–13 and attributed to enhanced cortico‐striatal plasticity and dopamine release and transporter function in the caudate nucleus 6,14 …”

Section: Introductionmentioning

confidence: 94%

“…Systematic reviews have confirmed the relative benefits of different types of exercise on subjective quality of life (QoL). 8,9 Motor benefits have also been found [9][10][11][12][13] and attributed to enhanced cortico-striatal plasticity and dopamine release and transporter function in the caudate nucleus. 6,14 One treatment programme originating in Australia is the 'PD Warrior' (PDW) programme, which was developed in 2012 and has since been widely taken up for the outpatient management of PD.…”

Section: Introductionmentioning

confidence: 99%

The ‘PD Warrior’ exercise programme improves motor outcomes and quality of life in patients with early Parkinson disease: results of a pilot study

Tucak,

Chih,

Mastaglia

et al. 2023

Internal Medicine Journal

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Background‘PD Warrior’ (PDW) is a popular exercise program for Parkinson's disease; however, there are no published studies on the outcomes of the program.AimsTo investigate short‐term functional and quality of life (QoL) outcomes after the PDW 10‐week program in a pilot study of individuals with early Parkinson's Disease (PD).MethodsTwenty individuals with PD (Hoehn & Yahr 1–3) attending a hospital outpatient clinic were recruited into the PDW 10‐week program, comprising a weekly 1‐h supervised class complemented by an individualised daily home exercise program. Participants had the following assessments at baseline and after completion of the program: Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS‐UPDRS) Part III, timed up‐and‐go (TUG), 10‐m walk test (10mWT), 6‐min walking test (6MWT), balance tests, fine motor skills, 7‐day Parkinson's KinetiGraph (PKG) and PDQ‐39 QoL scale.ResultsSeventeen individuals completed the program. Significant improvements were observed in MDS‐UPDRS motor score (P = 0.019, d = 0.68, MCID 7); 6MWT distance (P < 0.001, d = 1.16); walking time during motor or cognitive dual tasking (P = 0.006, d = 0.77; P = 0.005, d = 0.79, respectively); and the PDQ‐39 emotional well‐being subdomain (P = 0.009; MCID 4.2); as well as improvements trending to significance in bradykinesia (P = 0.025, d = 0.73), 10mWT walking time (P = 0.023, d = 0.61) and borderline improvement in balance (P = 0.056, d = 0.50).ConclusionsThe outcomes of this study support the efficacy of the PDW program in individuals with early PD and provide justification for future trials and investigation of its effects.

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“…19 In fact, one population-based study identified that an optimal amount of vigorous physical activity (140 minutes per week) can significantly reduce mortality due to Alzheimer's disease, potentially preventing 12 238 Alzheimer's related deaths each year in the US. 21 As physical activity can benefit one's muscular strength, motor function, emotional health, and quality of life, there are significant advantages of physical activity to individuals with neurological impairment such as stroke, 22 Huntington's disease, 23 Parkinson's disease, 24 and multiple sclerosis. 25 Accordingly, physical activity often serves as a mechanism to prevent, delay, and manage neurologic disease and promote brain health.…”

Section: Cognition Dementia and Other Neurologic Conditionsmentioning

confidence: 99%

Physical Activity and Brain Health: Integrating the Evidence Base into Workplace Health Promotion

Whitsel,

Ablah,

Pronk

et al. 2024

Am J Health Promot

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Physical exercise for people with Parkinson’s disease: a systematic review and network meta-analysis

Cited by 48 publications

References 336 publications

Editorial: Effects of aging on locomotor patterns

Editorial: Effects of aging on locomotor patterns

The ‘PD Warrior’ exercise programme improves motor outcomes and quality of life in patients with early Parkinson disease: results of a pilot study

Physical Activity and Brain Health: Integrating the Evidence Base into Workplace Health Promotion

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