Physical exercise induces hippocampal neurogenesis and prevents cognitive decline

Ma, Chao; Ma, Xiaotang; Wang, Jinju; Liu, Hua; Chen, Yanfang; Yang, Yi

doi:10.1016/j.bbr.2016.09.067

Cited by 153 publications

(107 citation statements)

References 103 publications

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“…More generally, physical exercise also increases neurotrophic factors (BDNF, IGF-1 and VEGF) and cardiovascular fitness, two factors that might be involved in mediating neuroplasticity 44 . Increased BDNF following exercise has been related to enhanced hippocampal plasticity and neurogenesis 45,46 , as well as with improved memory and executive functions in humans 47 . Importantly, BDNF is also one of the critical mechanisms underlying visual plasticity, regulating the critical period for ocular dominance plasticity 48–50 .…”

Section: Discussionmentioning

confidence: 99%

A new counter-intuitive therapy for adult amblyopia

Lunghi

Sframeli

Lepri

et al. 2018

Preprint

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Visual cortex plasticity is high during a critical period of early postnatal development, but rapidly diminishes with the transition to adulthood. Accordingly, visual disorders such as amblyopia (lazy eye), can be treated early in life by long-term occlusion of the non-amblyopic eye, but may become irreversible in adults, because of the decline in brain plasticity. Here we show that a novel counter-intuitive approach can promote the recovery of visual function in adult amblyopic patients: short-term occlusion of the amblyopic (not the fellow) eye, combined with physical exercise (cycling). After six brief (2h) training sessions, visual acuity improved in all ten patients (0.15±0.02 LogMar), and six of them also recovered stereopsis. The improvement was preserved for up to one year after training. A control experiment revealed that physical activity was crucial for the recovery of visual acuity and stereopsis. Thus, we propose a non-invasive therapeutic strategy for adult human amblyopia based an inverse-occlusion and physical exercise procedure.

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Section: Discussionmentioning

confidence: 99%

A new counter-intuitive therapy for adult amblyopia

Lunghi

Sframeli

Lepri

et al. 2018

Preprint

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“…Most prior studies have demonstrated the effects of exercise on cognitive impairment induced by several diseases (Baek, 2016; Ma et al, 2017). HFD-induced obesity model was used to indicate cognitive impairment, depression, and anxiety (Abildgaard et al, 2011; Kaczmarczyk et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

“…Also, brain-derived neurotrophic factor (BDNF) and tyrosine kinase B (TrkB) expression and cell proliferation in normal adolescent mice were increased after treadmill exercise for 12 weeks (Kim et al, 2016). Increased expression of hippocampal BDNF and enhanced cell proliferation caused by treadmill exercise might facilitate neuroplasticity in mice (Ma et al, 2017; Seo et al, 2014). The present results showed that treadmill exercise was similar level of control group on spatial learning ability and short-term memory.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the behavioral effects of exercise and high fat diet on cognitive function in adolescent rats

et al. 2016

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Adolescence is a critical period for neurodevelopment, neuronal plasticity, and cognitive function. Experiences of adolescence can be exerted positive and negative effects on brain development. Physical exercise has a positive effect on brain function, which is characterized by improving memory function and increased neural plasticity. High fat diet (HFD)-induced obesity has a negative effect on brain function, which is characterized by insulin resistance and neuroinflammation and reduced microvessel constructure. Although the positive effect of exercise and negative effect of obesity on cognitive function have been documented, it has not been well whether comparison of the effects of exercise and obesity on cognitive function in adolescent rats. In the present study, we evaluated the behavioral changes related to cognitive function induced by exercise and obesity in adolescent rats. Male Wistar rats were randomly divided into three groups: the control group (CON), the exercise group (Ex), the high fat diet group (HFD). The HFD containing fat 60% was freely provided. The present results showed that spatial learning ability and short-term memory did not show significant effect exercise as compared to the control group. The present results showed that spatial learning ability and short-term memory was significantly decreased HFD-induced obesity group as compared to the control group. These results suggest that positive effect of physical exercise in adolescence rats may be exerted no significant effect on cognitive function. But, negative effect of HFD-induced obesity might induce cognitive impairment. HFD-induced obesity in adolescent rats may be used as an animal model of neurodevelopmental disorders.

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“…Indeed, it has been reported that nonpharmacological interventions improve neural repair and synaptic plasticity in the central nervous system (CNS) . Physical exercise is one of the most important neuroprotective, noninvasive and nonpharmacological interventions in addition to be affordable and inexpensive for the population . Physical exercise has been proposed as one of the ways to counteract neurological and cognitive disorders in animal models and in human beings as well .…”

Section: Introductionmentioning

confidence: 99%

Strength exercise suppresses STZ‐induced spatial memory impairment and modulates BDNF/ERK‐CAMKII/CREB signalling pathway in the hippocampus of mice

Martini

Leite

Rosa

et al. 2020

Cell Biochemistry & Function

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Alzheimer's disease (AD) is a progressive neurodegenerative disorder that has generated scientific interest because of its prevalence in the population. Studies indicate that physical exercise promotes neuroplasticity and improves cognitive function in animal models and in human beings. The aim of the present study was to investigate the effects of strength exercise on the hippocampal protein contents and memory performance in mice subjected to a model of sporadic AD induced by streptozotocin (STZ). Swiss mice received two injections of STZ (3 mg/kg, intracerebroventricular). After 21 days, they began physical training using a ladde. Mice performed this protocol for 4 weeks. After the last exercise training session, mice performed the Morris Water Maze test. The samples of hippocampus were excised and used to determine protein contents of brain-derived neurotrophic factor (BDNF), extracellular signal-regulated kinase-Ca 2+ (ERK), calmodulindependent protein kinase (CAMKII) and cAMP-response element-binding protein (CREB) signalling pathway. Strength exercise was effective against the decrease in the time spent and distance travelled in the target quadrant by STZ-injected mice. Strength exercise was also effective against the reduction of mature BDNF, tropomyosin receptor kinase B and neuronal nuclear antigen (NeuN) hippocampal protein levels in STZ mice. The decrease in the hippocampal ratio of pERK/ERK, pCAMKII/CAMKII and pCREB/CREB induced by STZ was reversed by strength exercise. Strength exercise decreased Bax/Bcl2 ratio in the hippocampus of STZ-injected mice. The present study demonstrates that strength exercise modulated the hippocampal BDNF/ERK-CAMKII/CREB signalling pathway and suppressed STZ-induced spatial memory impairment in mice.

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Physical exercise induces hippocampal neurogenesis and prevents cognitive decline

Cited by 153 publications

References 103 publications

A new counter-intuitive therapy for adult amblyopia

A new counter-intuitive therapy for adult amblyopia

Comparison of the behavioral effects of exercise and high fat diet on cognitive function in adolescent rats

Strength exercise suppresses STZ‐induced spatial memory impairment and modulates BDNF/ERK‐CAMKII/CREB signalling pathway in the hippocampus of mice

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