Physical Exercise May Increase Plasma Concentration of High-Density Lipoprotein-Cholesterol in Patients With Alzheimer’s Disease

Jensen, Christer; Musaeus, Christian Sandøe; Frikke‐Schmidt, Ruth; Andersen, Birgitte; Beyer, Nina; Gottrup, Hanne; Høgh, Peter; Vestergaard, Karsten; Wermuth, Lene; Frederiksen, Kristian Steen; Waldemar, Gunhild; Hasselbalch, Steen G.; Simonsen, Anja Hviid

doi:10.3389/fnins.2020.00532

Cited by 10 publications

(5 citation statements)

References 47 publications

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“…Few other studies also proved the same objective [26,28]. Physical activity can decrease HDL levels and has proven to improve symptoms and progression of AD by a randomized control trial of 170 patients [28].…”

Section: Figure 2: Demonstrating the Process Of Synthesis Metabolismmentioning

confidence: 88%

“…Many researchers studied this protective role of HDL-C. Formiga et al included 321 patients in a cohort study and proved the association between decreased HDL and AD [27]. Few other studies also proved the same objective [26,28]. Physical activity can decrease HDL levels and has proven to improve symptoms and progression of AD by a randomized control trial of 170 patients [28].…”

Section: Figure 2: Demonstrating the Process Of Synthesis Metabolismmentioning

confidence: 99%

See 1 more Smart Citation

Plasma Lipids as Biomarkers for Alzheimer's Disease: A Systematic Review

Agarwal¹,

Khan²

2020

Cureus

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Section: Figure 2: Demonstrating the Process Of Synthesis Metabolismmentioning

confidence: 88%

Section: Figure 2: Demonstrating the Process Of Synthesis Metabolismmentioning

confidence: 99%

Plasma Lipids as Biomarkers for Alzheimer's Disease: A Systematic Review

Agarwal¹,

Khan²

2020

Cureus

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“…Beneficial effects of exercise on the lipid profile were observed by the decrement in TC ( Baker et al, 2010 ; Köbe et al, 2016 ; Ferreira et al, 2018 ; Stephen et al, 2021 ), TG ( Köbe et al, 2016 ; Ferreira et al, 2018 ), and LDL ( Ferreira et al, 2018 ). Exercise, especially aerobic exercise, has been reported effective in improving the lipid profile among healthy adults and even Alzheimer population ( Kelley et al, 2005 ; Jensen et al, 2020 ). Lipid contribution to Alzheimer’s disease can be explained by the involvement of apolipoprotein, which is a key lipid-transport protein in high-risk late-onset AD.…”

Section: Resultsmentioning

confidence: 99%

Changes in cardiovascular-health blood biomarkers in response to exercise intervention among older adults with cognitive frailty: A scoping review

Ibrahim

Ludin²,

Singh³

et al. 2023

Front. Physiol.

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Introduction: Cardiovascular health contributes significantly to the incidence of cognitive impairment. Prior to conducting exercise-related intervention, it is crucial to explore cardiovascular health blood parameters that have been commonly used as guidance for the purpose of monitoring. Information on the effectiveness of exercise on cardiovascular-related biomarkers is lacking, especially among older adults with cognitive frailty. Therefore, we aimed to review existing evidence on cardiovascular-related blood parameters and their changes following exercise intervention among older adults with cognitive frailty.Methods: A systematic search was conducted on PubMed, Cochrane, and Scopus databases. Related studies involving only human and full text in either English or Malay language were selected. Types of impairment were limited to cognitive impairment, frailty, and cognitive frailty. Studies were restricted to randomized controlled trial and clinical trial design studies. For charting purposes, all variables were extracted and tabulated. Trends in types of parameters studied were explored.Results: A total of 607 articles were screened, and the final 16 were included in this review. Four cardiovascular-related blood parameter categories were extracted: inflammatory, glucose homeostasis, lipid profile, and hemostatic biomarkers. The common parameters monitored were IGF-1 and HbA1c, glucose, and insulin sensitivity in some studies. Out of the nine studies on inflammatory biomarkers, exercise interventions showed a reduction in pro-inflammatory markers, namely, IL-6, TNF-α, IL-15, leptin, and C-reactive protein and an increase in anti-inflammatory markers, namely, IFN-γ and IL-10. Similarly, in all eight studies, glucose homeostasis-related biomarkers had improved with exercise intervention. The lipid profile was tested in five studies, with four studies showing improvements with exercise intervention via a decrease in total cholesterol, triglycerides, and low-density lipoprotein and an increase in high-density lipoprotein. A decrease in pro-inflammatory biomarkers and an increase in anti-inflammatory biomarkers were demonstrated with multicomponent exercise, including aerobic exercise in six studies and aerobic exercise on its own in the remaining two studies. Meanwhile, four out of six studies that yielded improvements in glucose homeostasis biomarkers involved only aerobic exercise and the remaining two studies involved multicomponent with aerobic exercise.Conclusion: The most consistent blood parameters studied were glucose homeostasis and inflammatory biomarkers. These parameters have been shown to improve with multicomponent exercise programs, particularly with the inclusion of aerobic exercise.

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“…142 Overall, available evidence based on meta-analysis and subgroup analysis suggested that subjects who are at high risk of cognitive decline may benefit most from single or multidomain interventions. 143 High-risk groups may include those with low cognitive reserve (eg, low education), 144 poor/suboptimal control in modifiable risk factors, 145,146 subtle or subjective cognitive decline, 145,147 ApoE ε4 carriers, 148,149 and concurrent amyloid pathology. 147 MRI substudies of the FINGER (Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability) and PreDIVA trials failed to show any beneficial effects of the multidomain intervention on the progression of cSVD.…”

Section: Multidomain Interventionsmentioning

confidence: 99%

Current and Future Treatments of Vascular Cognitive Impairment

Ip,

Ko,

Lam

et al. 2024

Stroke

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Nonamyloid sporadic cSVD is considered the most prevalent cause or pathological substrate of VCI. 20,21 It refers to diseased microscopic perforating cerebral arterioles, capillaries, and venules giving rise to abnormalities in the cerebral white and deep gray matter. 5 Driven by arteriosclerosis and fibrinoid necrosis, the arteriolar wall can be stenosed, occluded, dilated, or ruptured, which may result in lacunar infarcts or deep microparenchymal/macroparenchymal hemorrhages. 22 In addition, recent studies suggested that cSVD is a dynamic process that affects the whole brain, beginning at the cellular level that involves the components of neurovascular units, including endothelial cells, pericytes, vascular smooth muscle cells, glia, neurons, immune cells, and extracellular matrix. 23,24 These units regulate cerebral blood flow, endothelial function, BBB integrity, and neuroinflammation. 5,23,25 Endothelial dysfunction, astrocytopathy, and BBB leakage may occur when components of neurovascular units are diseased or damaged due to aging, vascular risk factors (eg, hypertension, hyperlipidemia, hyperhomocysteinemia, diabetes, smoking), 26,27 increase in pulsatile flow being transmitted to the cerebral small vessels secondary to aortic stiffness, 28 and genetic factors. 5,24,29,30 These pathological changes may lead to compromised cerebral

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Physical Exercise May Increase Plasma Concentration of High-Density Lipoprotein-Cholesterol in Patients With Alzheimer’s Disease

Cited by 10 publications

References 47 publications

Plasma Lipids as Biomarkers for Alzheimer's Disease: A Systematic Review

Plasma Lipids as Biomarkers for Alzheimer's Disease: A Systematic Review

Changes in cardiovascular-health blood biomarkers in response to exercise intervention among older adults with cognitive frailty: A scoping review

Current and Future Treatments of Vascular Cognitive Impairment

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