2021
DOI: 10.1038/s41380-021-01336-2
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Physical exercise rescues cocaine-evoked synaptic deficits in motor cortex

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Cited by 31 publications
(17 citation statements)
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“…[ 14–16 ] In the cortical region, we recently showed that repeated treadmill exercise facilitates spinogenesis and stabilization of newly formed synapses. [ 17–19 ] However, there is a major gap between exercise training and behavioral improvements due to the incomplete picture of how exercise is translated into synaptic modulations across multiple brain regions. To provide molecular explanations, it is worth noting that epigenetic regulation, such as histone modification, [ 20,21 ] microRNA, [ 22 ] and DNA methylation [ 23,24 ] all participate in mental and cognitive rehabilitation following exercise.…”
Section: Introductionmentioning
confidence: 99%
“…[ 14–16 ] In the cortical region, we recently showed that repeated treadmill exercise facilitates spinogenesis and stabilization of newly formed synapses. [ 17–19 ] However, there is a major gap between exercise training and behavioral improvements due to the incomplete picture of how exercise is translated into synaptic modulations across multiple brain regions. To provide molecular explanations, it is worth noting that epigenetic regulation, such as histone modification, [ 20,21 ] microRNA, [ 22 ] and DNA methylation [ 23,24 ] all participate in mental and cognitive rehabilitation following exercise.…”
Section: Introductionmentioning
confidence: 99%
“…Long-term exercise increases reward-related neural plasticity in brain structures, such as the dorsal striatum, nucleus accumbens, and lateral ventral tegmental area, and reduces MPA via its effects on reward stimulation ( Cassilhas et al, 2016 ). In empirical studies, physical exercise has been shown to improve a range of problems associated with symptoms of addiction, such as withdrawal and mood changes ( Chen et al, 2021 ; Cheng et al, 2021 ). These results suggest that physical exercise may provide valuable contribution to ameliorating MPA in college students.…”
Section: Discussionmentioning
confidence: 99%
“…METH exposure was administered as shown above. The moderate-intensity treadmill exercise program was modified from a mouse exercise protocol used in related studies ( Qu et al, 2020 ; Cheng et al, 2021 ). Treadmill exercise was carried out on a small animal treadmill (SA101B, SANS, China).…”
Section: Methodsmentioning
confidence: 99%