Physical exercise stimulates marked concomitant release of β-endorphin and adrenocorticotropic hormone (ACTH) in peripheral blood in man

Fraioli, F; Moretti, Costanzo; Paolucci, D; Alicicco, E.; Crescenzi, F; G, Fortunio

doi:10.1007/bf01953837

Cited by 210 publications

(49 citation statements)

References 6 publications

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“…The discrepancies between the results of Dr. Green and his coworkers and ours may be ascribed to the methodological differences, i.e., in our study the perfusion technique of the isolated pancreas was used, whereas in his study the incubation of the isolated islets was done. We used dynorphin (1-17) whereas he used dynorphin (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13). The concentration of dynorphin was higher in our study than that in theirs.…”

Section: Discussionmentioning

confidence: 51%

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Inhibitory effects of rimorphin and dynorphin on insulin secretion from the isolated, perfused rat pancreas.

Ishizuka

Toyota

Ono

et al. 1986

Tohoku J. Exp. Med.

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ISHIZUKA, J., TOYOTA, T., ONO, T., SASAKI, M., YANAIHARA, C. and YANAIHARA, N. Inhibitory Effects of Rimorphin and Dynorphin on Insulin Secretion from the Isolated, Perfused Rat Pancreas. Tohoku J. exp. Med., 1986, 150(1), 17-24 In order to settle the question about whether or not opioid peptides stimulate or inhibit insulin secretion, we studied effects of rimorphin and dynorphin, two members of the preproenkephalin B group, on glucose-induced insulin secretion in the isolated, perfused rat pancreas. These peptides (3.95 x 10-g M), like morphine (3.95 X 10-a M), significantly inhibited the glucose-induced insulin secretion. The inhibitory effect of rimorphin was attenuated by naloxone (1.2 x 10-6 M) and phentolamine (10-6 M), suggesting an involvement of adrenergic alpha receptors in the inhibition of glucose-induced insulin secretion mediated through specific opiate receptors. Rimorphin also inhibited glucose-induced insulin secretion even in the cysteamine-treated rat pancreas from which somatostatin had been depleted. Thus, somatostatin does not appear to play a major regulatory role in the insulin secretion in the pancreas. insulin secretion ; dynorphin ; rimorphin ; perfusion of the isolated rat pancreasThe fact that infusion of beta-endorphin diminished the glucagon and insulin responses to epinephrine indicates a possible role for the endogenous opiates in modulating the glucoregulatory response to the stress (El-Tayeb et al. 1985). It has been reported that endorphins and enkephalins are released in a variety of stress situations, including exercise (Fraioli et al. 1980) and hypoglycemia (Nakao et al. 1979). A question arises as to whether opioid peptides act on glucose metabolism via pancreatic hormones, i.e., insulin and glucagon. Pancreatic extracts have been shown to contain peptides eluting with similar characteristics to the enkephalins (Bruni et al. 1979). The existence of opioid peptides including enkephalins in the pancreas may support the concept that these peptides act as a physiologic regulator of pancreatic endocrine secretion. However, there have

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Section: Discussionmentioning

confidence: 51%

“…It has been reported that endorphins and enkephalins are released in a variety of stress situations, including exercise (Fraioli et al 1980) and hypoglycemia (Nakao et al 1979). A question arises as to whether opioid peptides act on glucose metabolism via pancreatic hormones, i.e., insulin and glucagon.…”

mentioning

confidence: 99%

Inhibitory effects of rimorphin and dynorphin on insulin secretion from the isolated, perfused rat pancreas.

Ishizuka

Toyota

Ono

et al. 1986

Tohoku J. Exp. Med.

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“…Previous reports have shown that naloxone increases plasma ACTH at rest in man (VOLAVKA et al, 1979), and that sufficiently intense exercise enhances ACTH release (FRAIOLI et a!.,1980;GAMBERT et al,1981). The seemingly discordant result of the lack of naloxone effect on resting plasma ACTH might depend on the naloxone dosage.…”

Section: Discussionmentioning

confidence: 91%

“…The endogeneous opiate /3-endorphin (BEP) is released from the pituitary during acute dynamic exercise (FRAIOLI et al, 1980;GAMBERT et al, 1981). The physiological role of exercise-induced elevation of BEP plasma concentration remains unresolved.…”

mentioning

confidence: 99%

“…Naloxone enhances pulmonary ventilation at high work intensities (GROSSMAN et al, 1984), which conforms to the inhibitory effects of endogeneous opiates on ventilatory regulation demonstrated by POKORSKI and LAHIRI (1981) and by . Naloxone also enhances, by an as yet undetermined mechanism, exercise-induced release of a number of hormones and neuromodulators (FRAIOLI et al, 1980;GAMBERT et al, 1981;GROSSMAN et al, 1984). GROSSMAN et al (1984) and SURBEY el al.…”

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confidence: 99%

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Opioid involvement in the perception of pain due to endurance exercise in trained man.

Paulev¹,

Thorbøll²,

Nielsen³

et al. 1989

Jpn.J.Physiol

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The purpose of this study was to evaluate the role of endogenous opiates in modulating physical performance during dynamic exercise in conscious man. The plasma concentration of fl-endorphin (BEP) and of adrenocorticotropic hormone (ACTH) along with muscle pain (McGuill Pain Questionnaire) were assessed in 17 trained, male runners before and after running the longest possible distance within 12 min (i.e., the Cooper test). Each runner participated twice in the test (double-blind cross-over design), with a 1-week interval-with or without an injection of the opiate antagonist naloxone (0.8 mg i.v.). The average (SEM) distance reached was 3,198 (45) m in the naloxone test and 3,240 (38) m in the placebo test. The BEP increased significantly during the tests by a factor of 4.1 on naloxone and by 2.8 on placebo (from the normal resting averages of 1.7 and 2.1 pmol/l, respectively). The ACTH also increased significantly by a factor of 2.0 on naloxone and 2.5 on placebo (from the normal resting averages of l 9.3 and 16.8 pmol/l, respectively). There were no significant differences between the naloxone and the placebo test with respect to the increments of BEP or ACTH by exercise. However, the perception of muscle pain was enhanced with naloxone. The increased perception of pain did not decrease the athletes ability to perform in terms of the distance run. We conclude that endogenous opiates are involved in the perception of pain associated with exhaustive exercise and may subserve psychological rather than physiological functions during exercise.

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Endorphins and exercise

Grossman

1984

Clinical Cardiology

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Physical exercise stimulates marked concomitant release of β-endorphin and adrenocorticotropic hormone (ACTH) in peripheral blood in man

Cited by 210 publications

References 6 publications

Inhibitory effects of rimorphin and dynorphin on insulin secretion from the isolated, perfused rat pancreas.

Inhibitory effects of rimorphin and dynorphin on insulin secretion from the isolated, perfused rat pancreas.

Opioid involvement in the perception of pain due to endurance exercise in trained man.

Endorphins and exercise

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