Physical Fitness and Reverse Cholesterol Transport

Olchawa, B.; Kingwell, Bronwyn A.; Hoang, Anh; Schneider, L.; Miyazaki, Osamu; Nestel, Paul J.; Sviridov, Dmitri

doi:10.1161/01.atv.0000128124.72935.0f

Cited by 78 publications

(62 citation statements)

References 34 publications

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“…Interestingly, the rise of CETP activity was disproportional to the rise of CETP mass implying a change in CETP specific activity. This discrepancy was observed by us before [16] and the likely explanation is the presence of "active" and "inactive" forms of CETP [22]; the mechanism of altering this ratio in HIVinfected patients is unclear.…”

Section: Discussionmentioning

confidence: 63%

“…Consistent with higher LCAT activity, the concentration of preβ 1 -HDL was lower in HIV-infected patients. However, increase in LCAT activity is generally associated with higher HDL-C levels [16], whereas the opposite was found in the HIV-infected patient groups. The likely explanation is our second finding that the activity of CETP was also increased in HIV-infected patients.…”

Section: Discussionmentioning

confidence: 88%

“…Plasma was then aliquoted, snap-frozen in liquid nitrogen and kept at −80°C until assayed. It was demonstrated previously that these conditions fully preserve the activity of plasma enzymes and the distribution of apoA-I among HDL subfractions [16].…”

Section: Blood Collectionmentioning

confidence: 82%

“…Cholesterol efflux to 2% patient plasma from RAW 264.7 mouse macrophages activated with LXR agonist TO-901317 (final concentration 1 μmol/L) was measured as described previously [16].…”

Section: Cholesterol Effluxmentioning

confidence: 99%

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HIV infection and high density lipoprotein metabolism

et al. 2008

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HIV infection and its treatment are associated with dyslipidemia, including hypoalphalipoproteinemia, and increased risk of cardiovascular disease. Parameters of HDL metabolism in HIV-positive patients were investigated in a cross-sectional study. The following groups of subjects were selected: i) 25 treatment-naïve HIV-infected patients or HIV-infected patients on long therapy break, ii) 28 HIV-infected patients currently treated with protease inhibitors, and iii) 33 HIV-negative subjects. Compared to the HIV-negative group, all groups of HIV-infected patients were characterized by significantly elevated triglyceride and apolipoprotein B levels, mass and activity of lecithin cholesterol acyl transferase and cholesteryl ester transfer protein (p<0.01). Total and LDL cholesterol was lower in treatment-naïve HIV-infected group only. HDL cholesterol and preβ 1 -HDL were significantly lower in all HIV-infected groups (p<0.05), while mean levels of apolipoprotein A-I (apoA-I) and ability of plasma to promote cholesterol efflux were similar in all groups. We found a positive correlation between apoA-I and levels of CD4+ cells (r 2 = 0.3, p<0.001). Plasma level of phospholipid transfer protein was reduced in the group on antiretroviral therapy. Taken together these results suggest that HIV infection is associated with modified HDL metabolism re-directing cholesterol to the apoB-containing lipoproteins and likely reducing the functionality of reverse cholesterol transport.

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Section: Discussionmentioning

confidence: 63%

Section: Discussionmentioning

confidence: 88%

Section: Blood Collectionmentioning

confidence: 82%

“…Cholesterol efflux to 2% patient plasma from RAW 264.7 mouse macrophages activated with LXR agonist TO-901317 (final concentration 1 μmol/L) was measured as described previously [16].…”

Section: Cholesterol Effluxmentioning

confidence: 99%

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HIV infection and high density lipoprotein metabolism

et al. 2008

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“…Plasma concentrations of HDL-C (1.4±0.1 versus 1.7±0.1 mmol/L, p<0.001) and ApoA-I (128±3 versus 145±_2 mg/dL p<0.001) were higher in athletes compared with active subjects [29]. Both systemic and selective hepatic over expression of ABCA1 in mice results in an increase of HDL-C plasma levels.…”

Section: Discussionmentioning

confidence: 87%

Effect of Eight Weeks of Wrestling and Circuit Fitness Training on APO Lipoprotein A-I and Lymphocyte ABCA1 Gene Expression in Well-Trained Wrestlers

Rashidlamir

Saadatnia

Ebrahimi-Atri

et al. 2011

International Journal of Wrestling Science

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ABSTRACT:Introduction: Atherosclerotic cardiovascular disease is now the leading cause of death in most countries. The ABCA1 gene provides instructions for the production of proteins (ATP-binding transporter protein) whose function is to export phospholipid and cholesterol out of the cells where they are bound to circulating apolipoprotein A1 (apoA1) and removed in the liver. Increased ABCA1 activity could inhibit atherosclerosis. In the present study, ABCA1 gene expression in lymphocytes and the associated effect of exercise were studied. Method: Subjects were 16 well-trained wrestlers randomly assigned into experimental and control groups. The experimental group performed 8 weeks of wrestling and circuit fitness training and the control group remained sedentary. Blood samples were collected 48 hours before the first session and 48 hours after the last session (subjects were fasting). After isolating lymphocytes by centrifugation, ABCA1 gene expression in lymphocytes was measured using semi-quantitative-RT-PCR. Data analyzed by SPSS software (version 16). Results: a significant increase in lymphocyte ABCA1 gene expression was shown following the 8 weeks of training (experimental p<0.001, t=-9.954). Plasma HDL-C concentrations and Apo A-I increased (P<0.001, t=4.97 P<0.05, t=2.67 respectively) and plasma LDL-C concentration decreased (P<0.001, t=4.35) in experimental group when compared with the control group. Discussion and Conclusion: Anaerobic exercises like wrestling and circuit fitness training can increase ABCA1 gene expression, an effective factor in the prevention of cardiovascular disease.

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Lifestyle Modifications

Kawano¹

2011

High‐Density Lipoproteins

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Physical Fitness and Reverse Cholesterol Transport

Abstract: Background-Physical exercise is associated with a decreased risk of cardiovascular disease, which may be partly caused by the effect of exercise on the lipoprotein profile. The most consistent effect of exercise on lipoprotein metabolism is an increase in high-density lipoprotein (HDL

Cited by 78 publications

References 34 publications

HIV infection and high density lipoprotein metabolism

HIV infection and high density lipoprotein metabolism

Effect of Eight Weeks of Wrestling and Circuit Fitness Training on APO Lipoprotein A-I and Lymphocyte ABCA1 Gene Expression in Well-Trained Wrestlers

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