Physical Fitness Tests and Type 2 Diabetes Among Japanese: A Longitudinal Study From the Niigata Wellness Study

Momma, Haruki; Sawada, Susumu S.; Kato, Kiminori; Gando, Yuko; Kawakami, Ryoko; Miyachi, Motohiko; Huang, Cong; Nagatomi, Ryoichi; Tashiro, Minoru; Ishizawa, Masahiro; Kodama, Satoru; Iwanaga, Midori; Fujihara, Kazuya; Sone, Hirohito

doi:10.2188/jea.je20170280

Cited by 43 publications

(52 citation statements)

References 37 publications

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“…However, the mechanism of the potential association between frailty and incident dementia is unclear. It has been shown that physical frailty increases the risk of diabetes mellitus and cardiovascular disease [15,16]. Moreover, a clinical-pathologic study found physical frailty to be associated with dementia pathology [17][18][19], and alterations in hippocampal synaptic function, neuronal membrane properties, and axonal trajectories, which might lead to dementia have been reported for people with frailty [20][21][22].…”

Section: Introductionmentioning

confidence: 99%

The association between frailty and incidence of dementia in Beijing: findings from 10/66 dementia research group population-based cohort study

Huang

Liu

et al. 2020

BMC Geriatr

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Background: The relationship between frailty and dementia is unclear and there are very few population-based studies regarding this issue in China. The purpose of this study is to estimate the association between frailty and incident dementia in China, and to explore different effects of frailty established by three definitions of frailty on dementia incidence. Methods: A five-year prospective cohort study was carried out in 2022 participants aged 65 years and over in urban and rural sites in Beijing, China. The participants were interviewed by trained community primary health care workers from 2004 to 2009. Frailty was defined using modified Fried frailty phenotype, physical frailty definition, and multidimensional frailty definition. Dementia was diagnosed using the 10/66 dementia criterion for calculating cumulative incidence. Both competing risk regression models and Cox proportional hazards models were applied to examine the associations between frailty at baseline and five-year cumulative incidence of dementia. Results: At the end of follow-up the five-year cumulative incidence rates of dementia with frailty and without frailty defined by the modified Fried frailty were 21.0% and 9.6%, those defined by the physical frailty were 19.9% and 9.0%, and those defined by the multidimensional frailty were 22.8% and 8.9%, respectively. Compared with non-frail participants, frail people had a higher risk of incident dementia using multidimensional frailty definition after adjusting covariates based on competing risk regression model (HR = 1.47, 95% CI 1.01~2.17) and Cox proportional hazards model (HR = 1.56, 95% CI 1.07~2.26). The association between frailty and incident dementia was statistically significant in participants in the upper three quartiles of age (aged 68 years and over) using the multidimensional frailty definition based on the competing risk regression model (HR = 1.61, 95% CI 1.06~2.43) and Cox proportional hazard model (HR = 1.76, 95% CI 1.19~2.61).

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Section: Introductionmentioning

confidence: 99%

The association between frailty and incidence of dementia in Beijing: findings from 10/66 dementia research group population-based cohort study

Huang

Liu

et al. 2020

BMC Geriatr

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“…6,7 Handgrip strength is an easy, non-invasive, and inexpensive measure of muscle strength in the elderly, which has been reported to be well-correlated with the muscle strength of limbs and the human trunk. 8,9 Additionally, it has been reported that lower handgrip strength is associated with a greater risk of diabetes mellitus, 10 cardiovascular disease, all-cause and cardiovascular mortality, and physical function and frailty. 11,12 Several population-based studies have also shown that reduced handgrip strength in late life was associated with increased risks of cognitive impairment and dementia.…”

Section: Introductionmentioning

confidence: 99%

Decline in Handgrip Strength From Midlife to Late-Life is Associated With Dementia in a Japanese Community: The Hisayama Study

Hatabe

Shibata

Ohara

et al. 2020

Journal of Epidemiology

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Background: The association between decline in handgrip strength from midlife to late life and dementia is unclear. Methods: Japanese community-dwellers without dementia aged 60 to 79 years (ie, individuals in late life; mean age, 68 years) were followed for 24 years (1988-2012) (n = 1,055); 835 of them had participated in a health examination in 1973-1974 (mean age, 53 years), and these earlier data were used for the midlife analysis. Using a Cox proportional hazards model, we estimated the risk conferred by a decline in handgrip strength over a 15-year period (1973-74 to 1988) from midlife to late life on the development of total dementia, Alzheimer's disease (AD), and vascular dementia (VaD) over the late-life follow-up period from 1988 to 2012. Results: During the follow-up, 368 subjects experienced total dementia. The age-and sex-adjusted incidence of total dementia increased significantly with greater decline in handgrip strength (increased or unchanged handgrip strength [≥+0%] 25.1, mildly decreased [−14 to −1%] 28.4, and severely decreased [≤−15%] 38.9 per 1,000 person-years). A greater decline in handgrip strength was significantly associated with higher risk of total dementia after adjusting for potential confounding factors; subjects with severely decreased handgrip strength had 1.51-fold (95% confidence interval, 1.14-1.99, P < 0.01) increased risk of total dementia compared to those with increased or unchanged handgrip strength. Similar significant findings were observed for AD, but not for VaD. Conclusions: Our findings suggest that a greater decline in handgrip strength from midlife to late life is an important indicator for late-life onset of dementia.

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“…We did not nd any relationship between the vertical jump test (power) or the step-test (endurance) and the risk of LS. Although the vertical jump test also shares characteristics in common with lower extremity strength, the vertical jump test does not only measure lower extremity strength, it also depends on speed (instantaneous power) [30,31]. The step-tests assesses the ability to perform a speci c muscular action for a prolonged period of time, and not just a bout of lower extremity strength [31].…”

Section: Discussionmentioning

confidence: 99%

“…Although the vertical jump test also shares characteristics in common with lower extremity strength, the vertical jump test does not only measure lower extremity strength, it also depends on speed (instantaneous power) [30,31]. The step-tests assesses the ability to perform a speci c muscular action for a prolonged period of time, and not just a bout of lower extremity strength [31]. Meanwhile, the LS is identi ed as a condition in which mobility functions such as sit-tostand or gait are reduced as a result of locomotive organ/system impairment [1].…”

Section: Discussionmentioning

confidence: 99%

Association of physical fitness and motor ability at young age with locomotive syndrome risk in middle-aged and older men: J-Fit+ Study

Shen

Suzuki

Kohmura

et al. 2020

Preprint

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Background Physical fitness and motor ability are associated with the incidence of locomotive syndrome (LS) in the elderly. The relationship between physical fitness and motor ability at a young age and LS risk in later life remains to be clarified. This study examined the association between physical fitness and motor ability among university students and their risk of LS in middle and old age. Methods The participants were 231 male alumni aged 48–65 years of the Department of Physical Education of a university in Japan. Physical fitness and motor ability test results during their fourth year of university were used. Physical fitness tests included side-step test, vertical jump tests, back muscle, grip strength, trunk lift, standing trunk flexion, and step-test. Motor ability was tested using the 50-meter, 1,500-meter run, running long jump, hand-ball throw, and pull-up test. LS risk was assessed using a seven-question standardized self-administered Loco-check questionnaire. Participants were divided into three groups (low, medium, and high) based on physical fitness and motor ability test results at young age and the LS risk was assessed at older age across the three groups using the Cox proportional hazards models. Results From the 2017 follow-up questionnaires, LS risk was suspected in 31 (13.4%) participants. Higher performance on the side-step test was associated with reduced risk of LS (hazard ratio 0.22; 95% confidence interval, 0.058–0.798, P=0.022). Conclusions Good agility (side-step test) at a young age may reduce future risk of LS among middle-aged and older men.

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Physical Fitness Tests and Type 2 Diabetes Among Japanese: A Longitudinal Study From the Niigata Wellness Study

Abstract: The performance of a simple single-leg balance test as well as that of a grip strength test were negatively associated with the risk of T2DM among Japanese.

Cited by 43 publications

References 37 publications

The association between frailty and incidence of dementia in Beijing: findings from 10/66 dementia research group population-based cohort study

The association between frailty and incidence of dementia in Beijing: findings from 10/66 dementia research group population-based cohort study

Decline in Handgrip Strength From Midlife to Late-Life is Associated With Dementia in a Japanese Community: The Hisayama Study

Association of physical fitness and motor ability at young age with locomotive syndrome risk in middle-aged and older men: J-Fit+ Study

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