Physical Growth and Mortality Risk in Children With Perinatally Acquired HIV.681

Berhane, Rahel; Aceng, Esther; Marum, Lawrence; Bagenda, Danstan; Bosch, R.; Ndugwa, Christopher; Olness, Karen

doi:10.1203/00006450-199604001-00703

Cited by 2 publications

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“…The similarities in the growth status of the children in our cohorts are very different from those reported by Berhane et al . (1996) in Uganda, Lepage et al .…”

Section: Discussioncontrasting

confidence: 99%

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Sociodemographic characteristics, care, feeding practices, and growth of cohorts of children born to HIV‐1 seropositive and seronegative mothers in Nairobi, Kenya

Sherry

Embreé

Mei

et al. 2000

Tropical Med Int Health

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SummaryOBJECTIVES To compare sociodemographic profiles, child care, child feeding practices and growth indices of children born to HIV-1 seropositive and seronegative mothers. METHODS A cohort study of 234 children (seropositive and seronegative) born to HIV-1 seropositive mothers and 139 children born to seronegative mothers in Pumwani Maternity Hospital which serves a low-income population in Nairobi, Kenya from December 1991 and January 1994. RESULTS With few exceptions, at the time of their birth children in all three cohorts had parents with similar characteristics, lived in similar housing in similar geographical areas, had their mothers as their primary care givers, had similar feeding practices and similar growth status and patterns. However, the HIV-1 seropositive mothers were slightly younger (23.8 years vs. 25.0 years, P , 0.01), if married they were less likely to be their husband's first wife (79% vs. 91%, P = 0.02) and more likely to have a one-room house (75% vs. 63%, P = 0.04). All three cohorts had mean Z-scores in length-for-age and in weight-for-height within the normal range ($ 2.0 Z-scores) from birth to 21 months with the exception of the length-for-age of the seropositive children at the 18-month visit. In all cohorts length-for-age became more compromised than weight-for-length, dropping to about 21.45 Z-score by 21 months; in contrast, weight-for-length dropped to about 20.5 Z-score by this age.The only statistically significant differences in growth indices among the three cohorts were between the two cohorts of seronegative children: those with seronegative mothers were less compromised in length-for-age at 1.5 months (mean Z-score = 20.19 vs. 20.48, P , 0.05) and more compromised in weightfor-length at 6 months (mean Z-score = 0.10 vs. 0.45, P , 0.05) and at 18 months (mean Z-score = 20.73 vs. 20.16, P , 0.05). 27^34% were exclusively breastfed at 1.5 months; 52^61% consumed solid foods in addition to breast milk by 2.5 months. CONCLUSIONS Low-income HIV-1 seropositive-and seronegative-born children were from families with similar characteristics and similar housing environments. Similar growth patterns in the cohorts suggest that the challenging environment and the choice of weaning foods had an impact on all three cohorts.The aggressive care given the children with HIV-1 seropositive mothers and their children may have reduced the progression and impact of HIV-1 disease on the growth of the seropositive children. Further research is needed to corroborate our findings to be certain that our results are not affected by loss to follow-up bias: we lost the same proportion in all three cohorts but cannot verify that the children we lost had the same growth patterns as those who remained in the study.keywords human immunodeficiency virus type 1,

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“…The similarities in the growth status of the children in our cohorts are very different from those reported by Berhane et al . (1996) in Uganda, Lepage et al .…”

Section: Discussioncontrasting

confidence: 99%

“…(1998) in Durban, South Africa. Berhane et al . (1996) found that infected infants who died before 2 years of age grew less well than those who lived beyond their second birthday.…”

Section: Discussionmentioning

confidence: 99%

Sociodemographic characteristics, care, feeding practices, and growth of cohorts of children born to HIV‐1 seropositive and seronegative mothers in Nairobi, Kenya

Sherry

Embreé

Mei

et al. 2000

Tropical Med Int Health

View full text Add to dashboard Cite

show abstract

“…In summary, various growth patterns have been described (Miller et al 1993;Saavedra et al 1995;The European Collaborative Study, 1995;Berhane et al 1996;Henderson et al 1996;Arpadi et al 1998), although in developed countries it appears that HIV-infected children have stable weight patterns, although below those of age-matched controls. Difference in growth patterns probably reflects the spectrum of disease in children with HIV, with many confounding factors, including treatment status and co-morbidities.…”

Section: Growth and Body Composition Of Human Immunodeficiency Virus-mentioning

confidence: 99%

Nutrition in paediatric human immunodeficiency virus infection

Miller

2000

Proc. Nutr. Soc.

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The nutritional condition of children with human immunodeficiency virus (HIV) infection continues to be a problem both in developed and developing countries. HIV-infected children grow below normal standards in both height and weight when compared with HIV-exposed non-infected children. These patterns persist over time. It is possible that acute infectious episodes and increased HIV viral burden contribute to decrements in all growth variables. Potential aetiologies for abnormal growth include inadequate dietary intake, gastrointestinal malabsorption, increased energy utilization and psycho-social problems. It is likely that all these factors contribute to the growth problems of these children to some extent. With the development of protease inhibitor anti-retroviral therapy and highly-active anti-retroviral treatment regimens, children with HIV infection in developed countries are living longer with a chronic illness. New nutritional problems have arisen with the development of the fat redistribution syndrome or lipodystrophy. Emerging problems are now being recognized, with the development of insulin resistance and truncal obesity which may potentially lead to premature cardiovascular disease.

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Physical Growth and Mortality Risk in Children With Perinatally Acquired HIV.681

Cited by 2 publications

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Sociodemographic characteristics, care, feeding practices, and growth of cohorts of children born to HIV‐1 seropositive and seronegative mothers in Nairobi, Kenya

Sociodemographic characteristics, care, feeding practices, and growth of cohorts of children born to HIV‐1 seropositive and seronegative mothers in Nairobi, Kenya

Nutrition in paediatric human immunodeficiency virus infection

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