The 2003 Schizophrenia PORT treatment recommendations and Mt. Sinai Conference Safety Monitoring recommendations generated guidelines for pharmacological treatment of schizophrenia and monitoring of antipsychotic side effects. This study examined rate of recommendation adherence and impact of adherence on outcomes of outpatients with schizophrenia or schizoaffective disorder in community mental health centers. Clinical practice was assessed as conformant, non-conformant, or not applicable. Treatment practices were conformant for antipsychotic dose (83%), use of antiparkinsonian (97%), antidepressant (100%), and antianxiety agents (90%), but not clozapine for residual positive symptoms (31%), monitoring weight gain (48%), glucose dysregulation (53%), hyperlipidemia (34%), or extrapyramidal symptoms (11%). Community mental health center treatment practices were largely conformant with 2003 Schizophrenia PORT treatment recommendations. There is less evidence patients who receive treatment in the community are adequately monitored for antipsychotic side effects per Mt. Sinai recommendations.