Physical Impairment and Social Life, Goals among Adult Long-term Survivors of Childhood Cancer: A Population-based Study from the Childhood Cancer Registry of Piedmont, Italy

Pastore, Guido; Mosso, Maria Luisa; Magnani, Corrado; Luzzatto, Lia; Bianchi, Maurizio; Terracini, Benedetto

doi:10.1177/030089160108700603

Cited by 35 publications

(45 citation statements)

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“…Cranial radiotherapy is known to be a strong risk factor for reduced educational attainment (Kelaghan et al, 1988;Haupt et al, 1994;Pastore et al, 2001;Langeveld et al, 2003;Mitby et al, 2003).This was reflected in our study by the better educational attainment level after infratentorial nonmedulloblastomas, probably treated with surgery only, in contrast to survivors of other brain tumours, who were more likely to have been treated with cranial radiotherapy. However, an internal comparison did not reach significance, which could be due to the analyses being based on small numbers in relation to this rather infrequent event.…”

Section: Discussionmentioning

confidence: 57%

“…Thus, in our study, support from well-educated parents tended to increase the probability of achieving the highest educational levels. Another study also found that the educational level of survivors of non-CNS tumours exceeded that of the general population (Pastore et al, 2001), and childhood cancer survivors have been described as more mature, with greater appreciation of parental support, than healthy controls (Maggiolini et al, 2000).…”

Section: Discussionmentioning

confidence: 99%

“…The reason is unclear. Previous studies showed that cancer survivors tend to undertake physical activity less than other persons (Mancini et al, 1989;Adamoli et al, 1997;Glaser et al, 1997) and that survivors of bone cancer with sequelae are more likely to have a high-school or college degree than those without sequelae (Pastore et al, 2001). The motivation of cancer survivors themselves, heightened awareness and support from parents or teachers (Peckham, 1991) or enrollment in special educational programmes (Mitby et al, 2003) might also play a role.…”

Section: Discussionmentioning

confidence: 99%

“…Some previous studies found that the overall educational attainment of survivors was equivalent to that of comparison groups, except for survivors of central nervous system (CNS) tumours and of acute lymphoblastic leukaemia who had received cranial radiotherapy (Kelaghan et al, 1988;Haupt et al, 1994;Pastore et al, 2001). Other studies concluded that survivors of childhood cancers more generally had significant deficits in educational outcome (Teta et al, 1986;Langeveld et al, 2003;Mitby et al, 2003).…”

mentioning

confidence: 99%

“…Other studies concluded that survivors of childhood cancers more generally had significant deficits in educational outcome (Teta et al, 1986;Langeveld et al, 2003;Mitby et al, 2003). Although well conducted, most previous studies were subject to incomplete participation, with rates as low as 61%, and suboptimal comparison groups, including siblings (Teta et al, 1986;Kelaghan et al, 1988;Haupt et al, 1994;Mitby et al, 2003) and population values (Pastore et al, 2001); healthy controls were used in only one study (Langeveld et al, 2003).…”

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confidence: 99%

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Educational attainment among survivors of childhood cancer: a population-based cohort study in Denmark

et al. 2004

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We identified 2384 patients in the Danish Cancer Register in whom cancer had been diagnosed in 1960 -1996 before they reached the age of 20 and compared them with 53 143 sex-and age-matched controls identified from the Register of Population Statistics. Complete education records and demographic and socioeconomic information for the period 1980 -2000 were obtained for both cohorts from Statistics Denmark. The rate ratio (RR) for educational attainment was estimated by discrete-time Cox regression analyses. An overall reduction in attaining basic education was found (RR, 0.90; 95% confidence interval, 0.83 -0.96). Female survivors of central nervous system (CNS) tumours showed the largest educational deficit (RR, 0.55; 95% confidence interval, 0.37 -0.82). Non-CNS tumour survivors attained education as controls at most levels. When the analyses were conditioned on completion of youth education, further educational attainment was not reduced for any group of survivors. These findings confirm that only survivors of CNS tumours in childhood experience significant educational deficits. The deficit was mainly seen among persons whose tumour was diagnosed before they reached the level of secondary education.

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Section: Discussionmentioning

confidence: 57%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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confidence: 99%

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Educational attainment among survivors of childhood cancer: a population-based cohort study in Denmark

et al. 2004

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Health Status of Childhood Cancer Survivors

Schwartz¹

2003

JAMA

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Burden of Childhood Cancer and the Social and Economic Challenges in Adulthood

Hernádfői,

Koch,

Kói

et al. 2024

JAMA Pediatr

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ImportanceSignificant advancements in pediatric oncology have led to a continuously growing population of survivors. Although extensive research is being conducted on the short-, medium-, and long-term somatic effects, reports on psychosocial reintegration are often conflicting; therefore, there is an urgent need to synthesize the evidence to obtain the clearest understanding and the most comprehensive answer.ObjectiveTo provide a comprehensive review and analysis of the socioeconomic attainment of childhood cancer survivors (CCSs) compared with their unaffected peers.Data SourcesA systematic review and meta-analysis was conducted using data obtained from a comprehensive search of MEDLINE (via PubMed), Embase, and CENTRAL (Cochrane Central Register of Controlled Trials) databases on October 23, 2021; the search was updated until July 31, 2023.Study SelectionEligible articles reported on educational attainment, employment, family formation, quality of life (QoL), or health-risk behavior-related outcomes of CCSs, and compared them with their unaffected peers. Study selection was performed in duplicate by 4 blinded independent coauthors.Data Extraction and SynthesisData extraction was performed in duplicate by 4 independent authors following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Outcome measures were odds ratios (ORs) and mean differences with 95% CIs; data were pooled using a random-effects model.ResultsThe search identified 43 913 articles, 280 of which were eligible for analysis, reporting data on a total of 389 502 survivors. CCSs were less likely to complete higher levels of education (OR, 0.69; 95% CI, 0.40-1.18), had higher odds of health-related unemployment (OR, 2.94; 95% CI, 1.90-4.57), and showed lower rates of marriage (OR, 0.72; 95% CI, 0.63-0.84) and parenthood (OR, 0.60; 95% CI, 0.49-0.74) compared with population-based controls.Conclusion and RelevanceStudy findings suggest that CCSs face several socioeconomic difficulties; as a result, the next goal of pediatric oncology should be to minimize adverse effects, as well as to provide lifelong survivorship support aimed at maximizing social reintegration.

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Physical Impairment and Social Life, Goals among Adult Long-term Survivors of Childhood Cancer: A Population-based Study from the Childhood Cancer Registry of Piedmont, Italy

Cited by 35 publications

References 27 publications

Educational attainment among survivors of childhood cancer: a population-based cohort study in Denmark

Educational attainment among survivors of childhood cancer: a population-based cohort study in Denmark

Health Status of Childhood Cancer Survivors

Burden of Childhood Cancer and the Social and Economic Challenges in Adulthood

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